Advanced search
Publication Cover
Drug Design, Development and Therapy Volume 7, 2013 - Issue
Submit an article Journal homepage
88
Views
55
CrossRef citations to date
0
Altmetric
Original Research

Phase II study of whole brain radiotherapy with or without erlotinib in patients with multiple brain metastases from lung adenocarcinoma

Hongqing Zhuang1 Department of Radiotherapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin, People’s Republic of China;2 National Clinical Research Center of Cancer, Tianjin, People’s Republic of China;3 Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin, People’s Republic of China;4 Tianjin Lung Cancer Center, Tianjin, People’s Republic of ChinaCorrespondence[email protected] [email protected]
,
Zhiyong Yuan1 Department of Radiotherapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin, People’s Republic of China;2 National Clinical Research Center of Cancer, Tianjin, People’s Republic of China;3 Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin, People’s Republic of China;4 Tianjin Lung Cancer Center, Tianjin, People’s Republic of China
,
Jun Wang1 Department of Radiotherapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin, People’s Republic of China;2 National Clinical Research Center of Cancer, Tianjin, People’s Republic of China;3 Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin, People’s Republic of China;4 Tianjin Lung Cancer Center, Tianjin, People’s Republic of China
,
Lujun Zhao1 Department of Radiotherapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin, People’s Republic of China;2 National Clinical Research Center of Cancer, Tianjin, People’s Republic of China;3 Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin, People’s Republic of China;4 Tianjin Lung Cancer Center, Tianjin, People’s Republic of China
,
Qingsong Pang1 Department of Radiotherapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin, People’s Republic of China;2 National Clinical Research Center of Cancer, Tianjin, People’s Republic of China;3 Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin, People’s Republic of China;4 Tianjin Lung Cancer Center, Tianjin, People’s Republic of China
&
Ping Wang1 Department of Radiotherapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin, People’s Republic of China;2 National Clinical Research Center of Cancer, Tianjin, People’s Republic of China;3 Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin, People’s Republic of China;4 Tianjin Lung Cancer Center, Tianjin, People’s Republic of ChinaCorrespondence[email protected] [email protected]
Pages 1179-1186 | Published online: 08 Oct 2013

Citations (55)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Ana P. S. Silva, Priscila V. Coelho, Maristella Anazetti & Patricia U. Simioni. (2017) Targeted therapies for the treatment of non-small-cell lung cancer: Monoclonal antibodies and biological inhibitors. Human Vaccines & Immunotherapeutics 13:4, pages 843-853.
Read now
Hongqing Zhuang, Xianzhi Zhao, Lujun Zhao, Joe Y Chang & Ping Wang. (2014) Progress of clinical research on targeted therapy combined with thoracic radiotherapy for non-small-cell lung cancer. Drug Design, Development and Therapy 8, pages 667-675.
Read now

Articles from other publishers (53)

Yuansha Ge, Bowen Xu, Heping Wang, Junmao Gao, Xiaoxiao Zhang, Taicheng Lu, Ruike Gao & Jie Li. (2022) Efficacy and Safety of EGFR Tyrosine Kinase Inhibitors Combined with Cranial Radiotherapy for Brain Metastases from Non-Small-Cell Lung Cancer: A Protocol for a Systematic Review and Meta-Analysis. BioMed Research International 2022, pages 1-7.
Crossref
Kai Zhou, Xiaoping Cai, Xiaoqiu Wang, Xiang Lan & Xuexia Zhang. (2021) Efficacy and safety of WBRT + EGFR‐TKI versus WBRT only in the treatment of NSCLC patients with brain metastasis : An updated meta‐analysis . Thoracic Cancer 13:4, pages 563-570.
Crossref
Dirk Rades, Sabine Bohnet & Steven E. Schild. 2023. Advances in Radiation Oncology in Lung Cancer. Advances in Radiation Oncology in Lung Cancer 755 777 .
Cristina Mantovani, Alessio Gastino, Marzia Cerrato, Serena Badellino, Umberto Ricardi & Mario Levis. (2021) Modern Radiation Therapy for the Management of Brain Metastases From Non-Small Cell Lung Cancer: Current Approaches and Future Directions. Frontiers in Oncology 11.
Crossref
Jiyun Lee & Myung-Ju Ahn. (2021) Brain metastases in patients with oncogenic-driven non-small cell lung cancer: Pros and cons for early radiotherapy. Cancer Treatment Reviews 100, pages 102291.
Crossref
Lihui Liu, Hua Bai, Samuel Seery, Sini Li, Chao Wang, Pei Xue, Jie Zhao & Jie Wang. (2021) Efficacy and safety of treatment modalities across EGFR selected/unselected populations with non-small cell lung cancer and brain metastases: A systematic review and Bayesian network meta-analysis. Lung Cancer 158, pages 74-84.
Crossref
Zhenzhou Yang, Yan Zhang, Rongqing Li, Abulimiti Yisikandaer, Biyong Ren, Jianguo Sun, Jianjun Li, Long Chen, Ren Zhao, Juying Zhang, Xuefeng Xia, Zhongxing Liao & David P Carbone. (2021) Whole-brain radiotherapy with and without concurrent erlotinib in NSCLC with brain metastases: a multicenter, open-label, randomized, controlled phase III trial. Neuro-Oncology 23:6, pages 967-978.
Crossref
Paola Anna Jablonska, Joaquim Bosch-Barrera, Diego Serrano, Manuel Valiente, Alfonso Calvo & Javier Aristu. (2021) Challenges and Novel Opportunities of Radiation Therapy for Brain Metastases in Non-Small Cell Lung Cancer. Cancers 13:9, pages 2141.
Crossref
Yuting Liu, Juanjuan Wang, Jingjing Wu, Qifan Yang, Yulan Zeng, Di Wu, Chen Tian, Yue Hu, Feifei Gu, Chang Li, Kai Zhang & Li Liu. (2021) The Efficacy of First-Generation EGFR-TKI Combined With Brain Radiotherapy as the First-Line Treatment for Lung Adenocarcinoma Patients With Brain Metastases and EGFR Sensitive Mutations: A Retrospective study. Technology in Cancer Research & Treatment 20, pages 153303382199781.
Crossref
Giuseppe Badalamenti, Massimiliano Cani, Lidia Rita Corsini, Lorena Incorvaia, Alessandro Inno & Stefania Gori. 2021. Practical Medical Oncology Textbook. Practical Medical Oncology Textbook 731 754 .
Muhammad Khan, Sumbal Arooj, Rong Li, Yunhong Tian, Jian Zhang, Jie Lin, Yingying Liang, Anan Xu, Ronghui Zheng, Mengzhong Liu & Yawei Yuan. (2020) Tumor Primary Site and Histology Subtypes Role in Radiotherapeutic Management of Brain Metastases. Frontiers in Oncology 10.
Crossref
Oscar Arrieta, Laura‐Alejandra Ramírez‐Tirado, Enrique Caballé‐Perez, Alberto Mejia‐Perez, Zyanya Lucia Zatarain‐Barrón, Andrés F. Cardona, Francisco Lozano‐Ruíz, Manuel Segura‐González, Graciela Cruz‐Rico, Federico Maldonado & Rafael Rosell. (2020) Response rate of patients with baseline brain metastases from recently diagnosed non‐small cell lung cancer receiving radiotherapy according to EGFR , ALK and KRAS mutation status . Thoracic Cancer 11:4, pages 1026-1037.
Crossref
Raj Singh, Eric J. Lehrer, Stephen Ko, Jennifer Peterson, Yanyan Lou, Alyx B. Porter, Rupesh Kotecha, Paul D. Brown, Nicholas G. Zaorsky & Daniel M. Trifiletti. (2020) Brain metastases from non-small cell lung cancer with EGFR or ALK mutations: A systematic review and meta-analysis of multidisciplinary approaches. Radiotherapy and Oncology 144, pages 165-179.
Crossref
Veronica Chiang & Stephanie Cheok. 2020. Central Nervous System Metastases. Central Nervous System Metastases 247 258 .
Wen-Ya Li, Ting-Ting Zhao, Hui-Mian Xu, Zhen-Ning Wang, Ying-Ying Xu, Yunan Han, Yong-Xi Song, Jian-Hua Wu, Hao Xu, Song-Cheng Yin, Xing-Yu Liu & Zhi-Feng Miao. (2019) The role of EGFR mutation as a prognostic factor in survival after diagnosis of brain metastasis in non-small cell lung cancer: a systematic review and meta-analysis. BMC Cancer 19:1.
Crossref
Alexander K. Erikson, Nathan Y. Yu, Janina T. Sheedy, Staci N. Shoudis, Harshita R. Paripati & Terence T. Sio. (2019) Erlotinib-Associated Rash Exacerbated by Whole-Brain Radiation Therapy: A Patient's Case Report. Practical Radiation Oncology 9:3, pages 128-131.
Crossref
Christan M Thomas & Chung-Shien Lee. (2018) Penetrating the evidence of EGFR and ALK tyrosine kinase inhibitors for non-small cell lung cancer brain metastases. Journal of Oncology Pharmacy Practice 25:3, pages 623-637.
Crossref
Ran Xu, Hong Shao, Jing Zhu, Qianqian Ju & Hui Shi. (2019) Combination strategies based on epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors for cancer patients. Medicine 98:13, pages e14135.
Crossref
Stefano Arcangeli, Barbara Alicia Jereczek-Fossa, Filippo Alongi, Cynthia Aristei, Carlotta Becherini, Liliana Belgioia, Michela Buglione, Luciana Caravatta, Rolando Maria D’Angelillo, Andrea Riccardo Filippi, Michele Fiore, Domenico Genovesi, Carlo Greco, Lorenzo Livi, Stefano Maria Magrini, Giulia Marvaso, Rosario Mazzola, Icro Meattini, Anna Merlotti, Isabella Palumbo, Stefano Pergolizzi, Sara Ramella, Umberto Ricardi, Elvio Russi, Marco Trovò, Alessandro Sindoni, Vincenzo Valentini & Renzo Corvò. (2019) Combination of novel systemic agents and radiotherapy for solid tumors – Part II: An AIRO (Italian association of radiotherapy and clinical oncology) overview focused on treatment toxicity. Critical Reviews in Oncology/Hematology 134, pages 104-119.
Crossref
Stefano Arcangeli, Barbara Alicia Jereczek-Fossa, Filippo Alongi, Cynthia Aristei, Carlotta Becherini, Liliana Belgioia, Michela Buglione, Luciana Caravatta, Rolando Maria D’Angelillo, Andrea Riccardo Filippi, Michele Fiore, Domenico Genovesi, Carlo Greco, Lorenzo Livi, Stefano Maria Magrini, Giulia Marvaso, Rosario Mazzola, Icro Meattini, Anna Merlotti, Isabella Palumbo, Stefano Pergolizzi, Sara Ramella, Umberto Ricardi, Elvio Russi, Marco Trovò, Alessandro Sindoni, Vincenzo Valentini & Renzo Corvò. (2019) Combination of novel systemic agents and radiotherapy for solid tumors – part I: An AIRO (Italian association of radiotherapy and clinical oncology) overview focused on treatment efficacy. Critical Reviews in Oncology/Hematology 134, pages 87-103.
Crossref
Ye Jiang, Jing Zhang, Juanjuan Huang, Bo Xu, Ning Li, Lei Cao & Mingdong Zhao. (2018) Erlotinib versus gefitinib for brain metastases in Asian patients with exon 19 EGFR-mutant lung adenocarcinoma: a retrospective, multicenter study. BMC Pulmonary Medicine 18:1.
Crossref
Xueyan Wang, Ye Xu, Weiqing Tang & Lingxiang Liu. (2018) Efficacy and Safety of Radiotherapy Plus EGFR-TKIs in NSCLC Patients with Brain Metastases: A Meta-Analysis of Published Data. Translational Oncology 11:5, pages 1119-1127.
Crossref
Maximilian Hochmair. (2018) Medical Treatment Options for Patients with Epidermal Growth Factor Receptor Mutation-Positive Non-Small Cell Lung Cancer Suffering from Brain Metastases and/or Leptomeningeal Disease. Targeted Oncology 13:3, pages 269-285.
Crossref
Shuai Liu, Peng Chen, Yan-Wei Liu, Xue-Nan Gu, Xiao-Guang Qiu & Bo Li. (2018) Role of Recursive Partitioning Analysis and Graded Prognostic Assessment on Identifying Non-Small Cell Lung Cancer Patients with Brain Metastases Who May Benefit from Postradiation Systemic Therapy. Chinese Medical Journal 131:10, pages 1206-1213.
Crossref
Nicolas Girard. (2018) Optimizing outcomes in EGFR mutation-positive NSCLC: which tyrosine kinase inhibitor and when? . Future Oncology 14:11, pages 1117-1132.
Crossref
Nicolas Girard, Delphine Cozzone, Lucie de Leotoing, Charlène Tournier, Alexandre Vainchtock, Bertrand Tehard & Alexis B. Cortot. (2018) Extra cost of brain metastases (BM) in patients with non-squamous non-small cell lung cancer (NSCLC): a French national hospital database analysis. ESMO Open 3:6, pages e000414.
Crossref
Bo Li, Zhao-Xia Dai, Yi-Dong Chen, Yan-Wei Liu, Shuai Liu, Xue-Nan Gu & Xiao-Guang Qiu. (2017) Systemic Therapy after Radiotherapy Significantly Reduces the Risk of Mortality of Patients with 1–3 Brain Metastases. Chinese Medical Journal 130:24, pages 2916-2921.
Crossref
A.V. Tallet, F. Dhermain, E. Le Rhun, G. Noël & Y.M. Kirova. (2017) Combined irradiation and targeted therapy or immune checkpoint blockade in brain metastases: toxicities and efficacy. Annals of Oncology 28:12, pages 2962-2976.
Crossref
Ling‐Ling Kong, Lin‐Lin Wang, Li‐Gang Xing & Jin‐Ming Yu. (2017) Current progress and outcomes of clinical trials on using epidermal growth factor receptor‐tyrosine kinase inhibitor therapy in non‐small cell lung cancer patients with brain metastases. Chronic Diseases and Translational Medicine 3:4, pages 221-229.
Crossref
Jianlong Tan, Min Li, Wen Zhong, Chengping Hu, Qihua Gu & Yali Xie. (2017) Tyrosine kinase inhibitors show different anti-brain metastases efficacy in NSCLC: A direct comparative analysis of icotinib, gefitinib, and erlotinib in a nude mouse model. Oncotarget 8:58, pages 98771-98781.
Crossref
Arnaldo Marín, Alex Renner, Laura Itriago & Manuel Álvarez. (2017) METÁSTASIS CEREBRALES: UNA MIRADA BIOLÓGICA Y CLÍNICA. Revista Médica Clínica Las Condes 28:3, pages 437-449.
Crossref
Tresa McGranahan & Seema Nagpal. (2017) A Neuro-oncologist’s Perspective on Management of Brain Metastases in Patients with EGFR Mutant Non-small Cell Lung Cancer. Current Treatment Options in Oncology 18:4.
Crossref
Heng Lin, Shuimei Luo, Lina Li, Sijing Zhou, Ruifen Shen, Haitao Yang, Yupeng Wu & Xianhe Xie. (2017) Efficacy and safety of antitumor agents plus radiotherapy compared with radiotherapy alone for brain metastases from lung cancer. Molecular and Clinical Oncology 6:3, pages 296-306.
Crossref
Maikel Verduin, Jaap D. Zindler, Hanneke M.A. Martinussen, Rob L.H. Jansen, Sander Croes, Lizza E.L. Hendriks, Danielle B.P. Eekers & Ann Hoeben. (2017) Use of Systemic Therapy Concurrent With Cranial Radiotherapy for Cerebral Metastases of Solid Tumors. The Oncologist 22:2, pages 222-235.
Crossref
Saiama N. Waqar, Daniel Morgensztern & Ramaswamy Govindan. (2017) Systemic Treatment of Brain Metastases. Hematology/Oncology Clinics of North America 31:1, pages 157-176.
Crossref
F. Couñago, A. Rodríguez, P. Calvo, J. Luna, J. L. Monroy, B. Taboada, V. Díaz & N. Rodríguez de Dios. (2016) Targeted therapy combined with radiotherapy in non-small-cell lung cancer: a review of the Oncologic Group for the Study of Lung Cancer (Spanish Radiation Oncology Society). Clinical and Translational Oncology 19:1, pages 31-43.
Crossref
Jonathan Khalifa, Arya Amini, Sanjay Popat, Laurie E. Gaspar & Corinne Faivre-Finn. (2016) Brain Metastases from NSCLC: Radiation Therapy in the Era of Targeted Therapies. Journal of Thoracic Oncology 11:10, pages 1627-1643.
Crossref
Tao Jiang, Chunxia Su, Xuefei Li, Chao Zhao, Fei Zhou, Shengxiang Ren, Caicun Zhou & Jun Zhang. (2016) EGFR TKIs plus WBRT Demonstrated No Survival Benefit Other Than That of TKIs Alone in Patients with NSCLC and EGFR Mutation and Brain Metastases. Journal of Thoracic Oncology 11:10, pages 1718-1728.
Crossref
Zarmeneh Aly & David M. Peereboom. (2016) Combination of Radiotherapy and Targeted Agents in Brain Metastasis: An Update. Current Treatment Options in Neurology 18:7.
Crossref
Tao Jiang, Weijie Min, Yanan Li, Zhijian Yue, Chunyan Wu & Caicun Zhou. (2016) Radiotherapy plus EGFR TKIs in non‐small cell lung cancer patients with brain metastases: an update meta‐analysis. Cancer Medicine 5:6, pages 1055-1065.
Crossref
Rimas V Lukas, Priya Kumthekar, Syeda Rizvi & Ravi Salgia. (2016) Systemic therapies in the treatment of non-small-cell lung cancer brain metastases. Future Oncology 12:8, pages 1045-1058.
Crossref
Stéphane Renaud, Mickaël Schaeffer, Anne-Claire Voegeli, Michèle Legrain, Eric Guérin, Nicolas Meyer, Bertrand Mennecier, Elisabeth Quoix, Pierre-Emmanuel Falcoz, Dominique Guénot, Gilbert Massard, Georges Noël & Michèle Beau-Faller. (2016) Impact of EGFR mutations and KRAS amino acid substitution on the response to radiotherapy for brain metastasis of non-small-cell lung cancer . Future Oncology 12:1, pages 59-70.
Crossref
Mao-hua Zheng, Hong-tao Sun, Ji-guang Xu, Gang Yang, Lei-ming Huo, Pan Zhang, Jin-hui Tian & Ke-hu Yang. (2016) Combining Whole-Brain Radiotherapy with Gefitinib/Erlotinib for Brain Metastases from Non-Small-Cell Lung Cancer: A Meta-Analysis. BioMed Research International 2016, pages 1-9.
Crossref
Mahmoud Toulany. 2016. Strategies to Enhance the Therapeutic Ratio of Radiation as a Cancer Treatment. Strategies to Enhance the Therapeutic Ratio of Radiation as a Cancer Treatment 253 287 .
Anja Derer, Lisa Deloch, Yvonne Rubner, Rainer Fietkau, Benjamin Frey & Udo S. Gaipl. (2015) Radio-Immunotherapy-Induced Immunogenic Cancer Cells as Basis for Induction of Systemic Anti-Tumor Immune Responses – Pre-Clinical Evidence and Ongoing Clinical Applications. Frontiers in Immunology 6.
Crossref
Ilaria Moschini, Cristina Dell'Anna, Pier Luigi Losardo, Paola Bordi, Nunziata D'Abbiero & Marcello Tiseo. (2015) Radiotherapy of non-small-cell lung cancer in the era of EGFR gene mutations and EGF receptor tyrosine kinase inhibitors . Future Oncology 11:16, pages 2329-2342.
Crossref
Lizza E.L. Hendriks, Janna Schoenmaekers, Jaap D. Zindler, Danielle B.P. Eekers, Ann Hoeben, Dirk K.M. De Ruysscher & Anne-Marie C. Dingemans. (2015) Safety of cranial radiotherapy concurrent with tyrosine kinase inhibitors in non-small cell lung cancer patients: A systematic review. Cancer Treatment Reviews 41:7, pages 634-645.
Crossref
Shuimei Luo, Long Chen, Xiuping Chen & Xianhe Xie. (2015) Evaluation on efficacy and safety of tyrosine kinase inhibitors plus radiotherapy in NSCLC patients with brain metastases. Oncotarget 6:18, pages 16725-16734.
Crossref
Yu Yang Soon, Cheng Nang Leong, Wee Yao Koh & Ivan Weng Keong Tham. (2015) EGFR tyrosine kinase inhibitors versus cranial radiation therapy for EGFR mutant non-small cell lung cancer with brain metastases: A systematic review and meta-analysis. Radiotherapy and Oncology 114:2, pages 167-172.
Crossref
Abhinav B. Chandra & Yiqing Xu. 2015. Brain Metastases from Primary Tumors. Brain Metastases from Primary Tumors 77 85 .
Hong-Qing Zhuang, Hongxia Zhuang, Qifu Bo, Yihang Guo, Jun Wang, Lu-Jun Zhao, Zhi-Yong Yuan & Ping Wang. (2014) Experimental study on the regulation of erlotinib-induced radiosensitization with an anti-c-MET monoclonal antibody. Cancer Cell International 14:1.
Crossref
Jingze Zhang, Jinming Yu, Xindong Sun & Xue Meng. (2014) Epidermal growth factor receptor tyrosine kinase inhibitors in the treatment of central nerve system metastases from non-small cell lung cancer. Cancer Letters 351:1, pages 6-12.
Crossref
Yun Hwa Jung, Chi Wha Han, Yun Duk Jung, Young Yun Cho & Deok Jae Han. (2014) Complete Remission of Brain Metastases in Non-Small Cell Lung Cancer Patients Harboring an EGFR Mutation Treated with Tyrosine Kinase Inhibitor without Radiotherapy: A Report of 3 Cases. Case Reports in Oncology 7:1, pages 149-154.
Crossref

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.