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Drug Design, Development and Therapy Volume 8, 2014 - Issue
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Original Research

Novel nanocrystal formulation of megestrol acetate has improved bioavailability compared with the conventional micronized formulation in the fasting state

Kyungho JangDepartment of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea
,
Seonghae YoonDepartment of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea
,
Sung-Eun KimDepartment of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea
,
Joo-Youn ChoDepartment of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea
,
Seo Hyun YoonDepartment of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea
,
Kyoung Soo LimDepartment of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea
,
Kyung-Sang YuDepartment of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea
,
In-Jin JangDepartment of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea
&
Howard LeeDepartment of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of KoreaCorrespondence[email protected]
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Pages 851-858 | Published online: 25 Jun 2014

Citations (13)

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Eun-Sol Ha, Jeong-Soo Kim, In-hwan Baek, Jin-Wook Yoo, Yunjin Jung, Hyung Ryong Moon & Min-Soo Kim. (2015) Development of megestrol acetate solid dispersion nanoparticles for enhanced oral delivery by using a supercritical antisolvent process. Drug Design, Development and Therapy 9, pages 4269-4277.
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Federica Leone & Roberta Cavalli. (2015) Drug nanosuspensions: a ZIP tool between traditional and innovative pharmaceutical formulations. Expert Opinion on Drug Delivery 12:10, pages 1607-1625.
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Articles from other publishers (11)

A. P. Paliy, K. A. Dotsenko, O. V. Pavlichenko, A. P. Palii & K. O. Rodionova. (2022) Correction of the sexual function in domestic animals by megestrol acetate. Journal for Veterinary Medicine, Biotechnology and Biosafety 8:1-2, pages 3-11.
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Xianghui Li, Shichao Ai, Xiaofeng Lu, Song Liu & Wenxian Guan. (2021) Nanotechnology-based strategies for gastric cancer imaging and treatment. RSC Advances 11:56, pages 35392-35407.
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Tahlia R. Meola, Paul Joyce, Anthony Wignall, Kristen E. Bremmell & Clive A. Prestidge. (2021) Harnessing the potential of nanostructured formulations to mimic the food effect of lurasidone. International Journal of Pharmaceutics 608, pages 121098.
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Mohammad Saiful Islam, Faradae Renner, Kimberly Foster, Martin S. Oderinde, Kevin Stefanski & Somenath Mitra. (2021) Hydrophilic and Functionalized Nanographene Oxide Incorporated Faster Dissolving Megestrol Acetate. Molecules 26:7, pages 1972.
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Wei Gao, Clairissa D. Corpstein & Tonglei Li. 2020. Biomaterials for Cancer Therapeutics. Biomaterials for Cancer Therapeutics 95 115 .
Kavita Joshi, Akhilesh Chandra, Keerti Jain & Sushama Talegaonkar. (2019) Nanocrystalization: An Emerging Technology to Enhance the Bioavailability of Poorly Soluble Drugs. Pharmaceutical Nanotechnology 7:4, pages 259-278.
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Shimul Halder, Hiroki Suzuki, Yoshiki Seto, Hideyuki Sato & Satomi Onoue. (2019) Megestrol acetate-loaded self-micellizing solid dispersion system for improved oral absorption and reduced food effect. Journal of Drug Delivery Science and Technology 49, pages 586-593.
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Fatemeh Farjadian, Amir Ghasemi, Omid Gohari, Amir Roointan, Mahdi Karimi & Michael R Hamblin. (2019) Nanopharmaceuticals and nanomedicines currently on the market: challenges and opportunities. Nanomedicine 14:1, pages 93-126.
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Josep M. Argilés, Francisco Javier López-Soriano, Britta Stemmler & Sílvia Busquets. (2017) Novel targeted therapies for cancer cachexia. Biochemical Journal 474:16, pages 2663-2678.
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Jinju Guk, Hankil Son, Dong Woo Chae & Kyungsoo Park. (2016) Quantitative Assessment of Food Effect on the Pharmacokinetics of Nano‐Crystallized Megestrol Acetate. Basic & Clinical Pharmacology & Toxicology 120:3, pages 270-277.
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Waseem Kaialy & Maen Al Shafiee. (2016) Recent advances in the engineering of nanosized active pharmaceutical ingredients: Promises and challenges. Advances in Colloid and Interface Science 228, pages 71-91.
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