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Drug Design, Development and Therapy Volume 8, 2014 - Issue
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Original Research

Anxiolytic and antidepressant-like activities of the novel and potent non-imidazole histamine H3 receptor antagonist ST-1283

Amine Bahi1 Department of Anatomy College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab EmiratesCorrespondence[email protected]
,
Johannes Stephan Schwed2 Institut für Pharmazeutische Chemie, Biozentrum, Johann Wolfgang Goethe University, Frankfurt, Germany;3 Heinrich Heine University Duesseldorf, Institut fuer Pharmazeutische and Medizinische Chemie, Düsseldorf, Germany
,
Miriam Walter2 Institut für Pharmazeutische Chemie, Biozentrum, Johann Wolfgang Goethe University, Frankfurt, Germany
,
Holger Stark3 Heinrich Heine University Duesseldorf, Institut fuer Pharmazeutische and Medizinische Chemie, Düsseldorf, Germany
&
Bassem Sadek4 Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab EmiratesCorrespondence[email protected]
Pages 627-637 | Published online: 28 May 2014

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Srisaiyini Kidnapillai, Chiara C. Bortolasci, Madhara Udawela, Bruna Panizzutti, Briana Spolding, Timothy Connor, Andrew Sanigorski, Olivia M. Dean, Tamsyn Crowley, Stéphane Jamain, Laura Gray, Elizabeth Scarr, Marion Leboyer, Brian Dean, Michael Berk & Ken Walder. (2020) The use of a gene expression signature and connectivity map to repurpose drugs for bipolar disorder. The World Journal of Biological Psychiatry 21:10, pages 775-783.
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Dorota Łażewska & Katarzyna Kieć-Kononowicz. (2018) Progress in the development of histamine H3 receptor antagonists/inverse agonists: a patent review (2013-2017). Expert Opinion on Therapeutic Patents 28:3, pages 175-196.
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Bassem Sadek, Ali Saad, Johannes Stephan Schwed, Lilia Weizel, Miriam Walter & Holger Stark. (2016) Anticonvulsant effects of isomeric nonimidazole histamine H3 receptor antagonists. Drug Design, Development and Therapy 10, pages 3633-3651.
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Swesha Chhabra & Sidharth Mehan. (2023) Matrine exerts its neuroprotective effects by modulating multiple neuronal pathways. Metabolic Brain Disease 38:5, pages 1471-1499.
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Hong Qian, Chang Shu, Ling Xiao & Gaohua Wang. (2022) Histamine and histamine receptors: Roles in major depressive disorder. Frontiers in Psychiatry 13.
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Nermin Eissa, Karthikkumar Venkatachalam, Petrilla Jayaprakash, Priya Yuvaraju, Markus Falkenstein, Holger Stark & Bassem Sadek. (2022) Experimental Studies Indicate That ST-2223, the Antagonist of Histamine H3 and Dopamine D2/D3 Receptors, Restores Social Deficits and Neurotransmission Dysregulation in Mouse Model of Autism. Pharmaceuticals 15:8, pages 929.
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Mera Alhusaini, Nermin Eissa, Ali K. Saad, Rami Beiram & Bassem Sadek. (2022) Revisiting Preclinical Observations of Several Histamine H3 Receptor Antagonists/Inverse Agonists in Cognitive Impairment, Anxiety, Depression, and Sleep–Wake Cycle Disorder. Frontiers in Pharmacology 13.
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Karthikkumar Venkatachalam, Sicheng Zhong, Mariam Dubiel, Grzegorz Satała, Bassem Sadek & Holger Stark. (2022) The Novel Pimavanserin Derivative ST-2300 with Histamine H3 Receptor Affinity Shows Reduced 5-HT2A Binding, but Maintains Antidepressant- and Anxiolytic-like Properties in Mice. Biomolecules 12:5, pages 683.
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Yongtao Bai, Yingchun Zhang, Shuolei Li, Wenzhou Zhang, Xinhui Wang, Baoxia He & Wenzheng Ju. (2021) Integrated Network Pharmacology Analysis and Experimental Validation to Investigate the Mechanism of Zhi-Zi-Hou-Po Decoction in Depression. Frontiers in Pharmacology 12.
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D. V. Maltsev, A. A. Spasov, M. V. Miroshnikov & M. O. Skripka. (2021) Current Approaches to the Search of Anxiolytic Drugs. Russian Journal of Bioorganic Chemistry 47:3, pages 622-652.
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Nermin Eissa, Petrilla Jayaprakash, Holger Stark, Dorota Łażewska, Katarzyna Kieć-Kononowicz & Bassem Sadek. (2020) Simultaneous Blockade of Histamine H3 Receptors and Inhibition of Acetylcholine Esterase Alleviate Autistic-Like Behaviors in BTBR T+ tf/J Mouse Model of Autism. Biomolecules 10:9, pages 1251.
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Nermin Eissa, Sheikh Azimullah, Petrilla Jayaprakash, Richard L. Jayaraj, David Reiner, Shreesh K. Ojha, Rami Beiram, Holger Stark, Dorota Łażewska, Katarzyna Kieć-Kononowicz & Bassem Sadek. (2020) The Dual-Active Histamine H3 Receptor Antagonist and Acetylcholine Esterase Inhibitor E100 Alleviates Autistic-Like Behaviors and Oxidative Stress in Valproic Acid Induced Autism in Mice. International Journal of Molecular Sciences 21:11, pages 3996.
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Cleiton Machado, Thiago Reis-Silva, Cassandra Lyra, Luciano Felicio & Bettina Malnic. (2018) Buried Food-seeking Test for the Assessment of Olfactory Detection in Mice. BIO-PROTOCOL 8:12.
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Cleiton Machado, Thiago Reis-Silva, Cassandra Lyra, Luciano Felicio & Bettina Malnic. (2018) Buried Food-seeking Test for the Assessment of Olfactory Detection in Mice. BIO-PROTOCOL 8:12.
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