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Review

Empagliflozin in the treatment of type 2 diabetes: evidence to date

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Pages 5793-5803 | Published online: 30 Oct 2015

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Nasir Shah, Vlado Perkovic & Sradha Kotwal. (2022) Impact of SGLT2 inhibitors on the kidney in people with type 2 diabetes and severely increased albuminuria. Expert Review of Clinical Pharmacology 15:7, pages 827-842.
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Saurabh B. Ganorkar, Shweta S. Sharma, Mangesh R. Patil, Preeti S. Bobade, Ashish M. Dhote & Atul A. Shirkhedkar. (2021) Pharmaceutical Analytical Profile for Novel SGL-2 Inhibitor: Dapagliflozin. Critical Reviews in Analytical Chemistry 51:8, pages 835-847.
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Maka Siamashvili & Stephen N. Davis. (2021) Sodium–glucose cotransporter 2 inhibitors for the management of type 2 diabetes. Expert Opinion on Pharmacotherapy 22:16, pages 2181-2198.
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Sirasa Ruangritchankul, Nancye M Peel, Leila Shafiee Hanjani & Leonard C Gray. (2020) The Changes in Medication Prescribing Among the Older People with Cognitive Impairment in the Acute Care Setting. Clinical Interventions in Aging 15, pages 865-876.
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Pranay Wal, Shruti Rathore, Namra Aziz, Yash Kumar Singh & Arpit Gupta. (2023) Aortic stenosis: a review on acquired pathogenesis and ominous combination with diabetes mellitus. The Egyptian Heart Journal 75:1.
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Suvedha Thiagaraj, Twisha S Shukla, Sai Dheeraj Gutlapalli, Hadi Farhat, Huma Irfan, Kanmani Muthiah, Namratha Pallipamu, Sogand Taheri & Safeera Khan. (2023) The Efficacy of Sodium-Glucose Cotransporter-2 Inhibitors in Improving Morbidity and Mortality of Heart Failure: A Systematic Review. Cureus.
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Rania M. Salama, Rodaina H. Ahmed, Alaa A. Farid, Basma A. AbdElSattar, Radwa M. AbdelBaset, Merna E. Youssef & Sara A. El Wakeel. (2023) Gastroprotective effect of dapagliflozin in ethanol-induced gastric lesions in rats: Crosstalk between HMGB1/RAGE/PTX3 and TLR4/MyD88/VEGF/PDGF signaling pathways. International Immunopharmacology 115, pages 109686.
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Vasiliki Chatziravdeli, George I. Lambrou, Athanasia Samartzi, Nikolaos Kotsalas, Eugenia Vlachou, John Komninos & Athanasios N. Tsartsalis. (2023) A Systematic Review and Meta-Analysis of Continuous Subcutaneous Insulin Infusion vs. Multiple Daily Injections in Type-2 Diabetes. Medicina 59:1, pages 141.
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Sanobia Yousuf & Muhammad Yakoob Ahmedani. (2022) Efficacy and safety of empagliflozin in people with type 2 diabetes during Ramadan fasting. Diabetes & Metabolic Syndrome: Clinical Research & Reviews 16:11, pages 102633.
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Nandhidha. RPunnagai. K. (2022) Evaluation of Anti-Inflammatory and Wound Healing Potential of Sodium Glucose Co-Transporter2 (SGLT2) Inhibitors. Research Journal of Pharmacy and Technology, pages 4457-4462.
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Rosanna Maccari & Rosaria Ottanà. (2022) Sodium-Glucose Cotransporter Inhibitors as Antidiabetic Drugs: Current Development and Future Perspectives. Journal of Medicinal Chemistry 65:16, pages 10848-10881.
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Min Hee Lee, Ian J. Neeland, Natalia de Albuquerque Rocha, Connor Hughes, Craig R. Malloy & Eunsook S. Jin. (2022) A randomized clinical trial evaluating the effect of empagliflozin on triglycerides in obese adults: Role of visceral fat. Metabolism Open 13, pages 100161.
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Anna Masajtis-Zagajewska, Tomasz Hołub, Katarzyna Pęczek, Agnieszka Makówka & Michał Nowicki. (2021) Different Effects of Empagliflozin on Markers of Mineral-Bone Metabolism in Diabetic and Non-Diabetic Patients with Stage 3 Chronic Kidney Disease. Medicina 57:12, pages 1352.
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Muhammad Afzal, Fahad Al-Abbasi, Muhammad Nadeem, Sultan Alshehri, Mohammed Ghoneim, Syed Imam, Waleed Almalki & Imran Kazmi. (2021) Sodium-Glucose Cotransporter-2 Inhibitors Improve Cardiovascular Dysfunction in Type 2 Diabetic East Asians. Metabolites 11:11, pages 794.
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Yu-Jen Wang, Francesco Paneni, Sokrates Stein & Christian M. Matter. (2021) Modulating Sirtuin Biology and Nicotinamide Adenine Diphosphate Metabolism in Cardiovascular Disease—From Bench to Bedside. Frontiers in Physiology 12.
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Dominik Polterauer, Jason D. Williams, Christopher A. Hone & C. Oliver Kappe. (2021) Telescoped lithiation, C-arylation and methoxylation in flow-batch hybrid toward the synthesis of canagliflozin. Tetrahedron Letters 82, pages 153351.
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Pallavi Prakash Chaurasia, Sagar Dholariya, Fenilkumar Kotadiya & Milav Bhavsar. (2021) A New Hope in Type 2 Diabetes Mellitus Management: Sodium-Glucose Cotransporter 2 Inhibitors. Cureus.
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振飞 欧. (2021) Empagliflozin in Patients with Type 2 Diabetes: A Meta-Analysis of Cardiovascular Remodeling. Advances in Clinical Medicine 11:02, pages 469-475.
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Shen Chang, Jian-You Chen, Yung-Jen Chuang & Bor-Sen Chen. (2020) Systems Approach to Pathogenic Mechanism of Type 2 Diabetes and Drug Discovery Design Based on Deep Learning and Drug Design Specifications. International Journal of Molecular Sciences 22:1, pages 166.
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Zoltán Papp & Attila Tóth. (2020) New treatment options to reduce heart failure hospitalization. ESC Heart Failure 7:6, pages 3271-3273.
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Matthew A Lee, George McMahon, Ville Karhunen, Kaitlin H Wade, Laura J Corbin, David A Hughes, George Davey Smith, Debbie A Lawlor, Marjo-Riitta Jarvelin & Nicholas J Timpson. (2020) Common variation at 16p11.2 is associated with glycosuria in pregnancy: findings from a genome-wide association study in European women. Human Molecular Genetics 29:12, pages 2098-2106.
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Kenichiro Sato, Tatsuo Mano, Atsushi Iwata & Tatsushi Toda. (2019) Subtype‐Dependent Reporting of Stroke With SGLT2 Inhibitors: Implications From a Japanese Pharmacovigilance Study. The Journal of Clinical Pharmacology 60:5, pages 629-635.
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Jayanta Dowarah & Ved Prakash Singh. (2020) Anti-diabetic drugs recent approaches and advancements. Bioorganic & Medicinal Chemistry 28:5, pages 115263.
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Gita Chawla & Krishna Kr Chaudhary. (2019) A complete review of empagliflozin: Most specific and potent SGLT2 inhibitor used for the treatment of type 2 diabetes mellitus. Diabetes & Metabolic Syndrome: Clinical Research & Reviews 13:3, pages 2001-2008.
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Wesley Nuffer, Briana Williams & Jennifer M. Trujillo. (2019) A review of sotagliflozin for use in type 1 diabetes. Therapeutic Advances in Endocrinology and Metabolism 10, pages 204201881989052.
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Alexander J.M. Brown, Chim Lang, Rory McCrimmon & Allan Struthers. (2017) Does dapagliflozin regress left ventricular hypertrophy in patients with type 2 diabetes? A prospective, double-blind, randomised, placebo-controlled study. BMC Cardiovascular Disorders 17:1.
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Natalia G. Vallianou, Eleni Geladari & Christos E. Kazazis. (2017) SGLT-2 inhibitors: Their pleiotropic properties. Diabetes & Metabolic Syndrome: Clinical Research & Reviews 11:4, pages 311-315.
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Fernando Gomez-Peralta, Cristina Abreu, Albert Lecube, Diego Bellido, Alfonso Soto, Cristóbal Morales, Miguel Brito-Sanfiel & Guillermo Umpierrez. (2017) Practical Approach to Initiating SGLT2 Inhibitors in Type 2 Diabetes. Diabetes Therapy 8:5, pages 953-962.
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Tushar Madaan, Mohd. Akhtar & Abul Kalam Najmi. (2016) Sodium glucose CoTransporter 2 (SGLT2) inhibitors: Current status and future perspective. European Journal of Pharmaceutical Sciences 93, pages 244-252.
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Xiaoyan Zhong, Dan Lai, Yun Ye, Xuping Yang, Bin Yu & Yilan Huang. (2016) Efficacy and safety of empagliflozin as add-on to metformin for type 2 diabetes: a systematic review and meta-analysis. European Journal of Clinical Pharmacology 72:6, pages 655-663.
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