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Drug Design, Development and Therapy Volume 9, 2015 - Issue
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Original Research

Plumbagin elicits differential proteomic responses mainly involving cell cycle, apoptosis, autophagy, and epithelial-to-mesenchymal transition pathways in human prostate cancer PC-3 and DU145 cells

Jia-Xuan Qiu1 School of Public Health, Wuhan University, Wuhan, Hubei, People’s Republic of China;2 Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People’s Republic of China
,
Zhi-Wei Zhou3 Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, FL, USA;4 Guizhou Provincial Key Laboratory for Regenerative Medicine, Stem Cell and Tissue Engineering Research Center and Sino-US Joint Laboratory for Medical Sciences, Guiyang Medical University, Guiyang, Guizhou, People’s Republic of China
,
Zhi-Xu He4 Guizhou Provincial Key Laboratory for Regenerative Medicine, Stem Cell and Tissue Engineering Research Center and Sino-US Joint Laboratory for Medical Sciences, Guiyang Medical University, Guiyang, Guizhou, People’s Republic of China
,
Ruan Jin Zhao5 Center for Traditional Chinese Medicine, Sarasota, FL, USA
,
Xueji Zhang6 Research Center for Bioengineering and Sensing Technology, University of Science and Technology Beijing, Beijing, People’s Republic of China
,
Lun Yang7 Bio-X Institutes, Key Laboratory for the Genetics of Development and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, People’s Republic of China
,
Shu-Feng Zhou3 Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, FL, USA;4 Guizhou Provincial Key Laboratory for Regenerative Medicine, Stem Cell and Tissue Engineering Research Center and Sino-US Joint Laboratory for Medical Sciences, Guiyang Medical University, Guiyang, Guizhou, People’s Republic of ChinaCorrespondence[email protected]
&
Zong-Fu Mao1 School of Public Health, Wuhan University, Wuhan, Hubei, People’s Republic of ChinaCorrespondence[email protected]
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Pages 349-417 | Published online: 07 Jan 2015

Citations (10)

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Read on this site (4)

Chihiro Ito, Takuya Matsui, Makiko Takano, Tian-Shung Wu & Masataka Itoigawa. (2018) Anti-cell proliferation effect of naphthoquinone dimers isolated from Plumbago zeylanica. Natural Product Research 32:18, pages 2127-2132.
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Shu-Ting Pan, Yiru Qin, Zhi-Wei Zhou, Zhi-Xu He, Xueji Zhang, Tianxin Yang, Yin-Xue Yang, Dong Wang, Shu-Feng Zhou & Jia-Xuan Qiu. (2015) Plumbagin suppresses epithelial to mesenchymal transition and stemness via inhibiting Nrf2-mediated signaling pathway in human tongue squamous cell carcinoma cells. Drug Design, Development and Therapy 9, pages 5511-5551.
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Ning-Kui Niu, Juan-Juan Yin, Yin-Xue Yang, Zi-Li Wang, Zhi-Wei Zhou, Zhi-Xu He, Xiao-Wu Chen, Xueji Zhang, Wei Duan, Tianxin Yang & Shu-Feng Zhou. (2015) Novel targeting of PEGylated liposomes for codelivery of TGF-β1 siRNA and four antitubercular drugs to human macrophages for the treatment of mycobacterial infection: a quantitative proteomic study. Drug Design, Development and Therapy 9, pages 4441-4470.
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Jia-Xuan Qiu, Zhi-Wei Zhou, Zhi-Xu He, Xueji Zhang, Shu-Feng Zhou & Shengrong Zhu. (2015) Estimation of the binding modes with important human cytochrome P450 enzymes, drug interaction potential, pharmacokinetics, and hepatotoxicity of ginger components using molecular docking, computational, and pharmacokinetic modeling studies. Drug Design, Development and Therapy 9, pages 841-866.
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Articles from other publishers (6)

Qingshan Tian, Hanxiao Niu, Dingyang Liu, Na Ta, Qing Yang, Vikram Norton, Yujing Wu, Amit K. Maiti, Hao Wu & Zhenzhong Zheng. (2021) Expression Signatures of Long Noncoding RNAs in Left Ventricular Noncompaction. Frontiers in Cardiovascular Medicine 8.
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Zhenhua Yin, Juanjuan Zhang, Lin Chen, Qingfeng Guo, Baocheng Yang, Wei Zhang & Wenyi Kang. (2020) Anticancer Effects and Mechanisms of Action of Plumbagin: Review of Research Advances. BioMed Research International 2020, pages 1-10.
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Surya Kant Tripathi, Kannan R. R. Rengasamy & Bijesh Kumar Biswal. (2020) Plumbagin engenders apoptosis in lung cancer cells via caspase-9 activation and targeting mitochondrial-mediated ROS induction. Archives of Pharmacal Research 43:2, pages 242-256.
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Lee. (2019) Reversal of Epithelial–Mesenchymal Transition by Natural Anti-Inflammatory and Pro-Resolving Lipids. Cancers 11:12, pages 1841.
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Marion Vanneste & Michael D. Henry. (2017) Targeting Phenotypic Plasticity in Prostate Cancer. Current Molecular Biology Reports 3:3, pages 183-196.
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Heng Luo, Ping Zhang, Xi Hang Cao, Dizheng Du, Hao Ye, Hui Huang, Can Li, Shengying Qin, Chunling Wan, Leming Shi, Lin He & Lun Yang. (2016) DPDR-CPI, a server that predicts Drug Positioning and Drug Repositioning via Chemical-Protein Interactome. Scientific Reports 6:1.
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