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Drug Design, Development and Therapy Volume 9, 2015 - Issue
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Original Research

Promoting endothelial function by S-nitrosoglutathione through the HIF-1α/VEGF pathway stimulates neurorepair and functional recovery following experimental stroke in rats

Mushfiquddin Khan1 Department of Pediatrics, Medical University of South Carolina, Charleston, SC, USACorrespondence[email protected]
,
Tajinder S Dhammu1 Department of Pediatrics, Medical University of South Carolina, Charleston, SC, USA
,
Fumiyo Matsuda1 Department of Pediatrics, Medical University of South Carolina, Charleston, SC, USA;2 School of Health Sciences, Kagoshima University, Kagoshima, Japan
,
Mauhammad Baarine3 Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, USA
,
Tejbir Singh Dhindsa1 Department of Pediatrics, Medical University of South Carolina, Charleston, SC, USA
,
Inderjit Singh1 Department of Pediatrics, Medical University of South Carolina, Charleston, SC, USA
&
Avtar K Singh3 Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, USA;4 Ralph H Johnson VA Medical Center, Charleston, SC, USACorrespondence[email protected]
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Pages 2233-2247 | Published online: 17 Apr 2015

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Yu Li, Mei-Ling Wang, Bo Zhang, Xiao-Xu Fan, Qin Tang, Xue Yu, Li-Na Li, Ang-Ran Fan, Hong-Sheng Chang & Lan-Zhen Zhang. (2022) Antidepressant-Like Effect and Mechanism of Ginsenoside Rd on Rodent Models of Depression. Drug Design, Development and Therapy 16, pages 843-861.
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Zujian Lan, Xiaoyu Xu, Wenkai Xu, Jin Li, Zengrong Liang, Xuefei Zhang, Ming Lei & Chunshun Zhao. (2015) Discovery of 3-n-butyl-2,3-dihydro-1H-isoindol-1-one as a potential anti-ischemic stroke agent. Drug Design, Development and Therapy 9, pages 3377-3391.
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Articles from other publishers (39)

Jiaming Zhang, Cunrui Li, Yihua Zhang, Jianbing Wu & Zhangjian Huang. (2023) Therapeutic potential of nitric oxide in vascular aging due to the promotion of angiogenesis. Chemical Biology & Drug Design.
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Jingying Liu, Qihang Luo, Jie Ke, DongDong Zhang, Yang Xu, Weijing Liao, Xiuping Chen & Xin Zhang. (2023) Enriched Environment Attenuates Ferroptosis after Cerebral Ischemia/Reperfusion Injury via the HIF-1α-ACSL4 Pathway. Oxidative Medicine and Cellular Longevity 2023, pages 1-14.
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Mushfiquddin KHAN. (2023) Rehabilitation in Animal Models of Stroke. Physical Therapy Research.
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Xiao-Xu Fan, Wen-Yan Sun, Yu Li, Qin Tang, Li-Na Li, Xue Yu, Shu-Yan Wang, Ang-Ran Fan, Xiang-Qing Xu & Hong-Sheng Chang. (2022) Honokiol improves depression-like behaviors in rats by HIF-1α- VEGF signaling pathway activation. Frontiers in Pharmacology 13.
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Alexey Polonikov, Iuliia Bocharova, Iuliia Azarova, Elena Klyosova, Marina Bykanova, Olga Bushueva, Anna Polonikova, Mikhail Churnosov & Maria Solodilova. (2022) The Impact of Genetic Polymorphisms in Glutamate-Cysteine Ligase, a Key Enzyme of Glutathione Biosynthesis, on Ischemic Stroke Risk and Brain Infarct Size. Life 12:4, pages 602.
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Hongzao Ni, Jinxiao Li, Jinyu Zheng & Botao Zhou. (2022) Cardamonin attenuates cerebral ischemia/reperfusion injury by activating the HIF ‐1α/ VEGFA pathway . Phytotherapy Research 36:4, pages 1736-1747.
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Mushfiquddin Khan, Fei Qiao, Pavan Kumar, SM Touhidul Islam, AvtarK Singh, Jeseong Won & Inderjit Singh. (2022) Neuroprotective effects of Alda-1 mitigate spinal cord injury in mice: involvement of Alda-1-induced ALDH2 activation-mediated suppression of reactive aldehyde mechanisms. Neural Regeneration Research 17:1, pages 185.
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Qian Cui, Yu-hui Ma, Hao-yu Yu, Yu-liang Zhang, Xiu-de Qin, Shao-qin Ge & Guo-wei Zhang. (2021) Systematic analysis of the mechanism of hydroxysafflor yellow A for treating ischemic stroke based on network pharmacology technology. European Journal of Pharmacology 908, pages 174360.
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Mushfiquddin Khan, Fei Qiao, S.M. Touhidul Islam, Tajinder S. Dhammu, Pavan Kumar, Jeseong Won, Avtar K. Singh & Inderjit Singh. (2021) GSNOR and ALDH2 alleviate traumatic spinal cord injury. Brain Research 1758, pages 147335.
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Bing Chun Yan, Jianwen Cao, Jiajia Liu, Yunhao Gu, Zhuobin Xu, Dandan Li & Lizeng Gao. (2020) Dietary Fe 3 O 4 Nanozymes Prevent the Injury of Neurons and Blood–Brain Barrier Integrity from Cerebral Ischemic Stroke . ACS Biomaterials Science & Engineering 7:1, pages 299-310.
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Sean P. Hopkins, Jitendra Pant, Marcus J. Goudie, Dieu Thao Nguyen & Hitesh Handa. (2020) Electrospun Bioabsorbable Fibers Containing S -Nitrosoglutathione for Tissue Engineering Applications . ACS Applied Bio Materials 3:11, pages 7677-7686.
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Wanting Li, Anqi Ye, Luyao Ao, Lin Zhou, Yunyi Yan, Yahui Hu, Weirong Fang & Yunman Li. (2020) Protective Mechanism and Treatment of Neurogenesis in Cerebral Ischemia. Neurochemical Research 45:10, pages 2258-2277.
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Lilia Carolina León-Moreno, Rolando Castañeda-Arellano, Irene Guadalupe Aguilar-García, María Fernanda Desentis-Desentis, Elizabeth Torres-Anguiano, Coral Estefanía Gutiérrez-Almeida, Luis Jesús Najar-Acosta, Gerardo Mendizabal-Ruiz, César Rodolfo Ascencio-Piña, Judith Marcela Dueñas-Jiménez, Jorge David Rivas-Carrillo & Sergio Horacio Dueñas-Jiménez. (2020) Kinematic Changes in a Mouse Model of Penetrating Hippocampal Injury and Their Recovery After Intranasal Administration of Endometrial Mesenchymal Stem Cell-Derived Extracellular Vesicles. Frontiers in Cellular Neuroscience 14.
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Mushfiquddin Khan, Pavan Kumar, Fei Qiao, S.M. Touhidul Islam, Avtar K. Singh, Je-Seong Won, Wayne Feng & Inderjit Singh. (2020) Targeting GSNOR for functional recovery in a middle-aged mouse model of stroke. Brain Research 1741, pages 146879.
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Shimeng Liu, Haiqing Zheng, Wengui Yu, Viswanathan Ramakrishnan, Shreyansh Shah, Louis Fernando Gonzalez, Inderjit Singh, Carmelo Graffagnino & Wuwei Feng. (2020) Investigation of S-Nitrosoglutathione in stroke: A systematic review and meta-analysis of literature in pre-clinical and clinical research. Experimental Neurology 328, pages 113262.
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Ting Hu, Rui Sun, Feihong Huang, Xiaoyun Liu, Zhenhui Duan, Ruidong Ye, Yunzi Li, Lulu Xiao, Zhiliang Guo, Qian Liu & Wusheng Zhu. (2020) CD99 mediates neutrophil transmigration through the bEnd.3 monolayer via the induction of oxygen-glucose deprivation. Biochemical and Biophysical Research Communications 526:3, pages 799-804.
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Shinghung Mak, Zheng Liu, Liangmiao Wu, Baojian Guo, Fangcheng Luo, Ziyan Liu, Shengquan Hu, Jiajun Wang, Guozhen Cui, Yewei Sun, Yuqiang Wang, Gaoxiao Zhang, Yifan Han & Zaijun Zhang. (2020) Pharmacological Characterizations of anti-Dementia Memantine Nitrate via Neuroprotection and Vasodilation in Vitro and in Vivo . ACS Chemical Neuroscience 11:3, pages 314-327.
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Yan-Hong Zhou, Qian-Feng Han, Lei Gao, Ying Sun, Zhan-Wei Tang, Meng Wang, Wei Wang & Heng-Chen Yao. (2020) HMGB1 Protects the Heart Against Ischemia–Reperfusion Injury via PI3K/AkT Pathway-Mediated Upregulation of VEGF Expression. Frontiers in Physiology 10.
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Mushfiquddin Khan, Tajinder S. Dhammu, Fei Qiao, Pavan Kumar, Avtar K. Singh & Inderjit Singh. (2019) S-Nitrosoglutathione Mimics the Beneficial Activity of Endothelial Nitric Oxide Synthase-Derived Nitric Oxide in a Mouse Model of Stroke. Journal of Stroke and Cerebrovascular Diseases 28:12, pages 104470.
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Lingna Deng, Fang Zhang, Yanlin Wu, Jiahao Luo, Xuhong Mao, Lingli Long, Maling Gou, Liqun Yang & David Y. B. Deng. (2019) RGD-Modified Nanocarrier-Mediated Targeted Delivery of HIF-1α-AA Plasmid DNA to Cerebrovascular Endothelial Cells for Ischemic Stroke Treatment . ACS Biomaterials Science & Engineering 5:11, pages 6254-6264.
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Nada M. Kamel, Mai A. Abd El Fattah, Hanan S. El-Abhar & Dalaal M. Abdallah. (2019) Novel repair mechanisms in a renal ischaemia/reperfusion model: Subsequent saxagliptin treatment modulates the pro-angiogenic GLP-1/cAMP/VEGF, ANP/eNOS/NO, SDF-1α/CXCR4, and Kim-1/STAT3/HIF-1α/VEGF/eNOS pathways. European Journal of Pharmacology 861, pages 172620.
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Dong‐Hua Mi, Hong‐Juan Fang, Guang‐Hui Zheng, Xian‐Hong Liang, Ya‐Rong Ding, Xin Liu & Li‐Ping Liu. (2018) DPP‐4 inhibitors promote proliferation and migration of rat brain microvascular endothelial cells under hypoxic/high‐glucose conditions, potentially through the SIRT1/HIF‐1/VEGF pathway. CNS Neuroscience & Therapeutics 25:3, pages 323-332.
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Parimala Narne, Vimal Pandey & Prakash Babu Phanithi. (2018) Role of Nitric Oxide and Hydrogen Sulfide in Ischemic Stroke and the Emergent Epigenetic Underpinnings. Molecular Neurobiology 56:3, pages 1749-1769.
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Mushfiquddin Khan & Inderjit Singh. (2019) Therapeutic exploitation of the S-nitrosoglutathione/S-nitrosylation mechanism for the treatment of contusion spinal cord injury. Neural Regeneration Research 14:6, pages 973.
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Mushfiquddin Khan, Tajinder S. Dhammu, Inderjit Singh & Avtar K. Singh. (2018) Amelioration of spinal cord injury in rats by blocking peroxynitrite/calpain activity. BMC Neuroscience 19:1.
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Mushfiquddin Khan, Anandakumar Shunmugavel, Tajinder S. Dhammu, Hamza Khan, Inderjit Singh & Avtar K. Singh. (2018) Combined treatment with GSNO and CAPE accelerates functional recovery via additive antioxidant activities in a mouse model of TBI. Journal of Neuroscience Research 96:12, pages 1900-1913.
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Xingyong Chen, Xu Zhang, Ting Chen, Xiulong Jiang, Xiaosong Wang, Huixin Lei & Yinzhou Wang. (2018) Inhibition of immunoproteasome promotes angiogenesis via enhancing hypoxia-inducible factor-1α abundance in rats following focal cerebral ischaemia. Brain, Behavior, and Immunity 73, pages 167-179.
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Atiq Hassan, Breanna M. Arnold, Sally Caine, Behzad M. Toosi, Valerie M. K. Verge & Gillian D. Muir. (2018) Acute intermittent hypoxia and rehabilitative training following cervical spinal injury alters neuronal hypoxia- and plasticity-associated protein expression. PLOS ONE 13:5, pages e0197486.
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Xiaoying Wu, Shengqun Liu, Zhenhua Hu, Guosong Zhu, Gaifang Zheng & Guangzhi Wang. (2018) Enriched housing promotes post-stroke neurogenesis through calpain 1-STAT3/HIF-1α/VEGF signaling. Brain Research Bulletin 139, pages 133-143.
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Mushfiquddin Khan, Tajinder S. Dhammu, Mauhamad Baarine, Jinsu Kim, Manjeet K. Paintlia, Inderjit Singh & Avtar K. Singh. (2018) GSNO promotes functional recovery in experimental TBI by stabilizing HIF-1α. Behavioural Brain Research 340, pages 63-70.
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Jieping Yan, Xin Huang, Danyan Zhu & Yijia Lou. (2017) Enhanced Aerobic Glycolysis by S-Nitrosoglutathione via HIF-1α Associated GLUT1/Aldolase A Axis in Human Endothelial Cells. Journal of Cellular Biochemistry 118:8, pages 2443-2453.
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Qiong Liu, Jun Liu, Pengqian Wang, Yingying Zhang, Bing Li, Yanan Yu, Haixia Dang, Haixia Li, Xiaoxu Zhang & Zhong Wang. (2017) Poly-dimensional network comparative analysis reveals the pure pharmacological mechanism of baicalin in the targeted network of mouse cerebral ischemia. Brain Research 1666, pages 70-79.
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Wei He, Ling Huang, Xiaoli Shen, Yanlin Yang, Dapeng Wang, Yue Yang & Xingen Zhu. (2017) Relationship between RSUME and HIF-1α/VEGF-A with invasion of pituitary adenoma. Gene 603, pages 54-60.
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Chin-Yi Cheng, Tin-Yun Ho, Chien-Yun Hsiang, Nou-Ying Tang, Ching-Liang Hsieh, Shung-Te Kao & Yu-Chen Lee. (2017) Angelica sinensis Exerts Angiogenic and Anti-apoptotic Effects Against Cerebral Ischemia–Reperfusion Injury by Activating p38MAPK/HIF-1α/VEGF-A Signaling in Rats . The American Journal of Chinese Medicine 45:08, pages 1683-1708.
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Binzhi Tang, Dejian Wang, Maojun Li, Qing Wu, Qian Yang, Wei Shi & Changhui Chen. (2016) An in vivo study of hypoxia-inducible factor-1α signaling in ginsenoside Rg1-mediated brain repair after hypoxia/ischemia brain injury. Pediatric Research 81:1, pages 120-126.
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Vinod B. Damodaran, Divya Bhatnagar, Heather Rubin & Melissa M. Reynolds. 2017. Nitric Oxide Donors. Nitric Oxide Donors 141 168 .
Katrin Rauen & Nikolaus Plesnila. 2017. Brain Edema. Brain Edema 353 373 .
Mushfiquddin Khan, Tajinder S Dhammu, Fumiyo Matsuda, Balasubramaniam Annamalai, Tejbir Singh Dhindsa, Inderjit Singh & Avtar K. Singh. (2016) Targeting the nNOS/peroxynitrite/calpain system to confer neuroprotection and aid functional recovery in a mouse model of TBI. Brain Research 1630, pages 159-170.
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Je-Seong Won, Balasubramaniam Annamalai, Seungho Choi, Inderjit Singh & Avtar K. Singh. (2015) S-nitrosoglutathione reduces tau hyper-phosphorylation and provides neuroprotection in rat model of chronic cerebral hypoperfusion. Brain Research 1624, pages 359-369.
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