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Review

Insulin administration: present strategies and future directions for a noninvasive (possibly more physiological) delivery

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Pages 3109-3118 | Published online: 17 Jun 2015

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Yazid Zaiki, Lee Yong Lim & Tin Wui Wong. (2023) Critical material designs for mucus- and mucosa-penetrating oral insulin nanoparticle development. International Materials Reviews 68:2, pages 121-139.
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Zuxian Chen, Shangcong Han, Xiaotang Yang, Lisa Xu, Hong Qi, Guizhou Hao, Jie Cao, Yan Liang, Qingming Ma, Guimin Zhang & Yong Sun. (2020) Overcoming Multiple Absorption Barrier for Insulin Oral Delivery Using Multifunctional Nanoparticles Based on Chitosan Derivatives and Hyaluronic Acid. International Journal of Nanomedicine 15, pages 4877-4898.
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Basem M. Mishriky, Doyle M. Cummings, Robert Tanenberg & Walter J. Pories. (2018) Re-examining insulin compared to non-insulin therapies for type 2 diabetes: when in the disease trajectory is insulin preferable?. Postgraduate Medicine 130:8, pages 653-659.
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Stanley S. Schwartz, Paul S. Jellinger & Mary E. Herman. (2016) Obviating much of the need for insulin therapy in type 2 diabetes mellitus: A re-assessment of insulin therapy’s safety profile. Postgraduate Medicine 128:6, pages 609-619.
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Articles from other publishers (46)

Yash Hadge, Nilesh Gorad, Rohit Auti, Rohit Auti & Saurabh Sivse. (2023) Review on Study of A Novel Insulin Delivery Method for the Treatment of Diabetes. International Journal of Advanced Research in Science, Communication and Technology, pages 172-179.
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Büşra Arpaç, Burcu Devrim Gökberk, Berrin Küçüktürkmen, Işıl Özakca Gündüz, İsmail Murat Palabıyık & Asuman Bozkır. (2023) Design and in vitro/in vivo Evaluation of Polyelectrolyte Complex Nanoparticles Filled in Enteric-Coated Capsules for Oral Delivery of Insulin. Journal of Pharmaceutical Sciences 112:3, pages 718-730.
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Tilahun Ayane Debele & Yoonjee Park. (2022) Application of Nanoparticles: Diagnosis, Therapeutics, and Delivery of Insulin/Anti-Diabetic Drugs to Enhance the Therapeutic Efficacy of Diabetes Mellitus. Life 12:12, pages 2078.
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Geremia B. Bolli, Alice Y. Y. Cheng & David R. Owens. (2022) Insulin: evolution of insulin formulations and their application in clinical practice over 100 years. Acta Diabetologica 59:9, pages 1129-1144.
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Sebastian Ciężki, Emilia Kurpiewska, Artur Bossowski & Barbara Głowińska-Olszewska. (2022) Multi-Faceted Influence of Obesity on Type 1 Diabetes in Children – From Disease Pathogenesis to Complications. Frontiers in Endocrinology 13.
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Gayatri Iyer, Sathish Dyawanapelly, Ratnesh Jain & Prajakta Dandekar. (2022) An overview of oral insulin delivery strategies (OIDS). International Journal of Biological Macromolecules 208, pages 565-585.
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Yumiko Tsushima, Keren Zhou, James F. Bena & Sangeeta R. Kashyap. (2022) Prevalence and Clinical Determinants of Obesity in Adults With Type 1 Diabetes Mellitus: A Single-Center Retrospective Observational Study. Endocrine Practice 28:4, pages 378-383.
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Li Yang, Yao Yang, Hongzhong Chen, Lin Mei & Xiaowei Zeng. (2022) Polymeric microneedle‐mediated sustained release systems: Design strategies and promising applications for drug delivery. Asian Journal of Pharmaceutical Sciences 17:1, pages 70-86.
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Pei Zhang, Cong Li, Tianhe Huang, Yuancheng Bai, Peng Quan, Wei Li, Zifan Zhang, Feng Zhang, Zehua Liu, Bowen Wan, Alexandra Correia, Jie Zhang, Xuri Wu, Jouni T. Hirvonen, Hélder A. Santos, Jin Fan, Ting Cai & Dongfei Liu. (2021) Inhibiting Phase Transfer of Protein Nanoparticles by Surface Camouflage–A Versatile and Efficient Protein Encapsulation Strategy. Nano Letters 21:22, pages 9458-9467.
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Emma McAlister, Melissa Kirkby, Juan Domínguez-Robles, Alejandro J. Paredes, Qonita Kurnia Anjani, Kurtis Moffatt, Lalitkumar K. Vora, Aaron R.J. Hutton, Peter E. McKenna, Eneko Larrañeta & Ryan F. Donnelly. (2021) The role of microneedle arrays in drug delivery and patient monitoring to prevent diabetes induced fibrosis. Advanced Drug Delivery Reviews 175, pages 113825.
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V. Manimaran, Ponnurengam Malliappan Sivakumar, J. Narayanan, Shanmugam Parthasarathi & Pranav Kumar Prabhakar. (2021) Nanoemulsions: A Better Approach for Antidiabetic Drug Delivery. Current Diabetes Reviews 17:4, pages 486-495.
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Dale S. Edgerton, Mary C. Moore, Justin M. Gregory, Guillaume Kraft & Alan D. Cherrington. (2021) Importance of the route of insulin delivery to its control of glucose metabolism. American Journal of Physiology-Endocrinology and Metabolism 320:5, pages E891-E897.
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Gary F. Lewis & Patricia L. Brubaker. (2021) The discovery of insulin revisited: lessons for the modern era. Journal of Clinical Investigation 131:1.
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Najeeb Shah, Mohammed Altigani Abdalla, Harshal Deshmukh & Thozhukat Sathyapalan. (2021) Therapeutics for type-2 diabetes mellitus: a glance at the recent inclusions and novel agents under development for use in clinical practice. Therapeutic Advances in Endocrinology and Metabolism 12, pages 204201882110421.
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Dessi P. Zaharieva, Ananta Addala, Kimber M. Simmons & David M. Maahs. (2020) Weight Management in Youth with Type 1 Diabetes and Obesity: Challenges and Possible Solutions. Current Obesity Reports 9:4, pages 412-423.
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Salma Seyam, Norsyafikah Asyilla Nordin & Mulham Alfatama. (2020) Recent Progress of Chitosan and Chitosan Derivatives-Based Nanoparticles: Pharmaceutical Perspectives of Oral Insulin Delivery. Pharmaceuticals 13:10, pages 307.
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Minglong Chen, Guilan Quan, Ying Sun, Dan Yang, Xin Pan & Chuanbin Wu. (2020) Nanoparticles-encapsulated polymeric microneedles for transdermal drug delivery. Journal of Controlled Release 325, pages 163-175.
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Daniela F.S. Fonseca, Paulo C. Costa, Isabel F. Almeida, Patrícia Dias-Pereira, Inês Correia-Sá, Verónica Bastos, Helena Oliveira, Margarida Duarte-Araújo, Manuela Morato, Carla Vilela, Armando J.D. Silvestre & Carmen S.R. Freire. (2020) Pullulan microneedle patches for the efficient transdermal administration of insulin envisioning diabetes treatment. Carbohydrate Polymers 241, pages 116314.
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Christian von Loeffelholz, Daniel Thomas-Rüddel, Michael Bauer & Andreas Birkenfeld. (2018) Effect of Magnesium Loading Dose on Insulin Resistance in Patients With Stress-Induced Hyperglycemia: A Randomized Clinical Trial. Journal of Intensive Care Medicine 35:7, pages 694-695.
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Cheng Zhang, Sheng Hong, Miao-Deng Liu, Wu-Yang Yu, Ming-Kang Zhang, Lu Zhang, Xuan Zeng & Xian-Zheng Zhang. (2020) pH-sensitive MOF integrated with glucose oxidase for glucose-responsive insulin delivery. Journal of Controlled Release 320, pages 159-167.
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Fereshteh Bayat, Reza Hosseinpour-Moghadam, Fatemeh Mehryab, Yousef Fatahi, Niayesh Shakeri, Rassoul Dinarvand, Timo L.M. Ten Hagen & Azadeh Haeri. (2020) Potential application of liposomal nanodevices for non-cancer diseases: an update on design, characterization and biopharmaceutical evaluation. Advances in Colloid and Interface Science 277, pages 102121.
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Holly K. O'Donnell & Kimberly A. Driscoll. 2020. Adherence and Self-Management in Pediatric Populations. Adherence and Self-Management in Pediatric Populations 47 83 .
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Pratyusa Sahoo, Kok Hoong Leong, Shaik Nyamathulla, Yoshinori Onuki, Kozo Takayama & Lip Yong Chung. (2019) Chitosan complexed carboxymethylated iota-carrageenan oral insulin particles: Stability, permeability and in vivo evaluation. Materials Today Communications 20, pages 100557.
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Camila Cubayachi, Camila Nunes Lemos, Francieli Pereira, Karina Dias, Rondinelli Donizetti Herculano, Osvaldo de Freitas & Renata F.V. Lopez. (2019) Silk fibroin films stabilizes and releases bioactive insulin for the treatment of corneal wounds. European Polymer Journal 118, pages 502-513.
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Najma Easa, Raid G. Alany, Mark Carew & Anil Vangala. (2019) A review of non-invasive insulin delivery systems for diabetes therapy in clinical trials over the past decade. Drug Discovery Today 24:2, pages 440-451.
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Prangmalee Leurcharusmee, Guy Kositratna, De Q. Tran & Thomas Schricker. (2018) Perioperative insulin therapy. Asian Biomedicine 11:5, pages 395-404.
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Pernille Kihl, Lukasz Krych, Karsten Buschard, Johnna D. Wesley, Witold Kot, Axel Kornerup Hansen, Dennis S. Nielsen & Matthias G. von Herrath. (2018) Oral insulin does not alter gut microbiota composition of NOD mice. Diabetes/Metabolism Research and Reviews 34:6, pages e3010.
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