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Drug, Healthcare and Patient Safety Volume 8, 2016 - Issue

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Original Research

Positive clinical outcomes derived from using Streptococcus salivarius K12 to prevent streptococcal pharyngotonsillitis in children: a pilot investigation

Francesco Di Pierro1 Scientific Department, Velleja Research, MilanCorrespondence[email protected]

Maria Colombo2 Pediatric Department, University of Parma, Parma

Alberto Zanvit3 Stomatology Institute

Amilcare S Rottoli4 Pediatric Department, Uboldo Hospital, Cernusco S/N, Milan, Italy

Pages 77-81 | Published online: 21 Nov 2016

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Alexander Bertuccioli, Marco Gervasi, Giosuè Annibalini, Beatrice Binato, Fabrizio Perroni, Marco B. L. Rocchi, Davide Sisti & Stefano Amatori. (2023) Use of Streptococcus salivarius K12 in supporting the mucosal immune function of active young subjects: A randomised double-blind study. Frontiers in Immunology 14.
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Vania Arboleda, Kawther N Elsouri, Samantha E Heiser, Isabel Bernal, Marc M Kesselman & Michelle Demory Beckler. (2023) Oral Microbiome as a Tool of Systemic Disease on Cleft Patients: A New Landscape. Cureus.
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Navjyoti Chakraborty, Shivani Kumar, Sumit Kumar Verma, Ram Singh Purty, Adreeja Basu & Sayan Chatterjee. 2023. Lantibiotics as Alternative Therapeutics. Lantibiotics as Alternative Therapeutics 221 239 .

Gemma A. Laws, Liam K. Harold, John R. Tagg & John D. F. Hale. (2022) Interferon Gamma Response in Human Saliva Following Exposure to the Oral Probiotic Streptococcus salivarius BLIS K12. Probiotics and Antimicrobial Proteins.
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Francesco Di Pierro, Somia Iqtadar, Sami Ullah Mumtaz, Alexander Bertuccioli, Martino Recchia, Nicola Zerbinati & Amjad Khan. (2022) Clinical Effects of Streptococcus salivarius K12 in Hospitalized COVID-19 Patients: Results of a Preliminary Study. Microorganisms 10:10, pages 1926.
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Xinquan Li, Qiang Wang, Xiafen Hu & Wanxin Liu. (2022) Current Status of Probiotics as Supplements in the Prevention and Treatment of Infectious Diseases. Frontiers in Cellular and Infection Microbiology 12.
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J.D.F. HaleR. JainP.A. WescombeJ.P. BurtonR.R. SimonJ.R. Tagg. (2022) Safety assessment of Streptococcus salivarius M18 a probiotic for oral health . Beneficial Microbes 13:1, pages 47-60.
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Andrea Stašková, Miriam Sondorová, Radomíra Nemcová, Jana Kačírová & Marián Maďar. (2021) Antimicrobial and Antibiofilm Activity of the Probiotic Strain Streptococcus salivarius K12 against Oral Potential Pathogens. Antibiotics 10:7, pages 793.
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Yan Wang, Jiatong Li, Haonan Zhang, Xin Zheng, Jiantao Wang, Xiaoyue Jia, Xian Peng, Qian Xie, Jing Zou, Liwei Zheng, Jiyao Li, Xuedong Zhou & Xin Xu. (2021) Probiotic Streptococcus salivarius K12 Alleviates Radiation-Induced Oral Mucositis in Mice. Frontiers in Immunology 12.
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Jennifer Jörissen, Marianne F. L. van den Broek, Ilke De Boeck, Wannes Van Beeck, Stijn Wittouck, An Boudewyns, Paul Van de Heyning, Vedat Topsakal, Vincent Van Rompaey, Ine Wouters, Liesbet Van Heirstraeten, Pierre Van Damme, Surbi Malhotra-Kumar, Heidi Theeten, Olivier M. Vanderveken & Sarah Lebeer. (2021) Case-Control Microbiome Study of Chronic Otitis Media with Effusion in Children Points at Streptococcus salivarius as a Pathobiont-Inhibiting Species. mSystems 6:2.
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Xue-Rui Shi, Bo-Yan Chen, Wen-Zhen Lin, Yu-Lin Li, Yong-Li Wang, Yan Liu, Jing-Juan Huang, Wei-Wei Zhang, Xiao-Xin Ma, Shuai Shao, Ruo-Gu Li & Sheng-Zhong Duan. (2021) Microbiota in Gut, Oral Cavity, and Mitral Valves Are Associated With Rheumatic Heart Disease. Frontiers in Cellular and Infection Microbiology 11.
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Laura García-Curiel, Ma. del Rocío López-Cuellar, Adriana Inés Rodríguez-Hernández & Norberto Chavarría-Hernández. (2021) Toward understanding the signals of bacteriocin production by Streptococcus spp. and their importance in current applications. World Journal of Microbiology and Biotechnology 37:1.
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Carla Vacca, Maria Paola Contu, Cecilia Rossi, Maria Laura Ferrando, Cornelio Blus, Serge Szmukler-Moncler, Alessandra Scano & Germano Orrù. (2020) In vitro Interactions between Streptococcus intermedius and Streptococcus salivarius K12 on a Titanium Cylindrical Surface. Pathogens 9:12, pages 1069.
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С.И. Ильченко, А.А. Фиалковская & Т.В. Можейко. (2020) Prevention of Recurrent Respiratory Diseases in Children with Microaspiration Syndrome. Оториноларингология. Восточная Европа:3, pages 278-285.
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Abdelahhad Barbour, Philip Wescombe & Leif Smith. (2020) Evolution of Lantibiotic Salivaricins: New Weapons to Fight Infectious Diseases. Trends in Microbiology 28:7, pages 578-593.
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Michael T. Murray & John Nowicki. 2020. Textbook of Natural Medicine. Textbook of Natural Medicine 1814 1816.e1 .

Linna An & Wilfred A. van der Donk. 2020. Comprehensive Natural Products III. Comprehensive Natural Products III 119 165 .

Roberta De Grandi, Lorenzo Drago, Alessandro Bidossi, Marta Bottagisio, Matteo Gelardi & Elena De Vecchi. (2018) Putative Microbial Population Shifts Attributable to Nasal Administration of Streptococcus salivarius 24SMBc and Streptococcus oralis 89a. Probiotics and Antimicrobial Proteins 11:4, pages 1219-1226.
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Lijun Hu, Qinghua Mao, Peiru Zhou, Xin Lv, Hong Hua & Zhimin Yan. (2019) Effects of Streptococcus salivarius K12 with nystatin on oral candidiasis—RCT . Oral Diseases 25:6, pages 1573-1580.
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C.R. Wilcox, B. Stuart, H. Leaver, M. Lown, M. Willcox, M. Moore & P. Little. (2019) Effectiveness of the probiotic Streptococcus salivarius K12 for the treatment and/or prevention of sore throat: a systematic review. Clinical Microbiology and Infection 25:6, pages 673-680.
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Jelena Marinković, Tatjana Marković, Biljana Miličić, Marina Soković, Ana Ćirić & Dejan Marković. 2019. Essential Oil Research. Essential Oil Research 211 233 .

Hagen Frickmann, Caroline Klenk, Philipp Warnke, Sylvio Redanz & Andreas Podbielski. (2018) Influence of probiotic culture supernatants on in vitro biofilm formation of staphylococci. European Journal of Microbiology and Immunology 8:4, pages 119-127.
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Amelia T Soderholm, Timothy C Barnett, Matthew J Sweet & Mark J Walker. (2018) Group A streptococcal pharyngitis: Immune responses involved in bacterial clearance and GAS-associated immunopathologies. Journal of Leukocyte Biology 103:2, pages 193-213.
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Positive clinical outcomes derived from using Streptococcus salivarius K12 to prevent streptococcal pharyngotonsillitis in children: a pilot investigation

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Positive clinical outcomes derived from using Streptococcus salivarius K12 to prevent streptococcal pharyngotonsillitis in children: a pilot investigation

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