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Drug, Healthcare and Patient Safety Volume 3, 2011 - Issue
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Review

Suicidal behavior and antiepileptic drugs in epilepsy: analysis of the emerging evidence

Marco Mula1 Department of Clinical and Experimental Medicine, Amedeo Avogadro University and Division of Neurology, University Hospital Maggiore della Carità, Novara, ItalyCorrespondence[email protected]
&
Dale C Hesdorffer2 Gertrude H Sergievsky Center and Department of Epidemiology, Columbia University, New York, NY, USA
Pages 15-20 | Published online: 16 Jun 2011

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Gautam Rao, Sherwin Mashkouri, David Aum, Paul Marcet & Cesar V Borlongan. (2017) Contemplating stem cell therapy for epilepsy-induced neuropsychiatric symptoms. Neuropsychiatric Disease and Treatment 13, pages 585-596.
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Marco Mula & Josemir W Sander. (2015) Suicide and epilepsy: do antiepileptic drugs increase the risk?. Expert Opinion on Drug Safety 14:4, pages 553-558.
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Articles from other publishers (27)

Nadia Sadanandan, Madeline Saft, Bella Gonzales-Portillo & Cesar V. Borlongan. (2021) Multipronged Attack of Stem Cell Therapy in Treating the Neurological and Neuropsychiatric Symptoms of Epilepsy. Frontiers in Pharmacology 12.
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Julie W. Dreier, Carsten B. Pedersen, Christiane Gasse & Jakob Christensen. (2019) Antiepileptic Drugs and Suicide: Role of Prior Suicidal Behavior and Parental Psychiatric Disorder. Annals of Neurology 86:6, pages 951-961.
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Yasmina Molero, Henrik Larsson, Brian M D’Onofrio, David J Sharp & Seena Fazel. (2019) Associations between gabapentinoids and suicidal behaviour, unintentional overdoses, injuries, road traffic incidents, and violent crime: population based cohort study in Sweden. BMJ, pages l2147.
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Oh-Young Kwon & Sung-Pa Park. (2019) Usefulness of the Liverpool Adverse Events Profile for predicting a high risk of suicidality in people with drug-resistant epilepsy. Seizure 67, pages 65-70.
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Daniel Navin Olschewski, Prisca R. Bauer & Josemir W. Sander. 2019. The Comorbidities of Epilepsy. The Comorbidities of Epilepsy 1 11 .
Stephanie Lichtor, Khalid Afzal, Jenna Shapiro, Tina Drossos, Karam Radwan, Seeba Anam & Sucheta Connolly. (2018) Anxiety: a Primer for the Pediatrician. Current Treatment Options in Pediatrics 4:1, pages 70-93.
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Yuchen Wang, Mary L Wagner, Kenneth R Kaufman, Kristin Maletsky, Kartik SivaraamanRam Mani. (2017) Topiramate Extended-Release Options: A Focus on Efficacy and Safety in Epilepsy and Comorbidities. Clinical Medicine Insights: Therapeutics 9, pages 1179559X1769460.
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Ivan Rektor, Steven C. Schachter, Ravindra Arya, Shahar Arzy, Hilde Braakman, Martin J. Brodie, Peter Brugger, Bernard S. Chang, Alla Guekht, Bruce Hermann, Dale C. Hesdorffer, Marilyn Jones-Gotman, Andres M. Kanner, Luis Garcia-Larrea, Pavel Mareš, Marco Mula, Miri Neufeld, Gail L. Risse, Philippe Ryvlin, Margitta Seeck, Torbjörn Tomson & Amos D. Korczyn. (2015) Third International Congress on Epilepsy, Brain, and Mind: Part 2. Epilepsy & Behavior 50, pages 138-159.
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James E. Frampton. (2015) Perampanel: A Review in Drug-Resistant Epilepsy. Drugs 75:14, pages 1657-1668.
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Dinkar Kulshreshtha, Pradeep Maurya, Ajai Singh & Anup Thacker. (2018) Withdrawal of anti-epileptic drugs: A review. International Journal of Epilepsy 02:01, pages 038-043.
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Marco Mula. (2014) Comments on Jones JE et al. Rates and risk factors for suicide, suicidal ideation, and suicide attempts in chronic epilepsy. Epilepsy & Behavior 2003;4(Suppl. 3):S31-38. Epilepsy & Behavior 40, pages 16-17.
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Vera Cristina Terra, Luciano de Paola & Carlos Eduardo Silvado. (2014) Are children affected by epileptic neuropsychiatric comorbidities?. Epilepsy & Behavior 38, pages 8-12.
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Sherese Ali. 2014. Women with Epilepsy. Women with Epilepsy 20 33 .
Simone Frizell Reiter, Gyri Veiby, Anne-Kjersti Daltveit, Bernt A. Engelsen & Nils Erik Gilhus. (2013) Psychiatric comorbidity and social aspects in pregnant women with epilepsy — The Norwegian Mother and Child Cohort Study. Epilepsy & Behavior 29:2, pages 379-385.
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Boghos I Yerevanian & Young Mee Choi. (2013) Impact of psychotropic drugs on suicide and suicidal behaviors. Bipolar Disorders 15:5, pages 594-621.
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Marco Mula & Josemir W Sander. (2013) Suicide risk in people with epilepsy taking antiepileptic drugs. Bipolar Disorders 15:5, pages 622-627.
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Emilio Russo, Serafina Chimirri, Rossana Aiello, Salvatore De Fazio, Antonio Leo, Vincenzo Rispoli, Rosario Marra, Angelo Labate, Pasquale De Fazio, Rita Citraro & Giovambattista De Sarro. (2013) Lamotrigine positively affects the development of psychiatric comorbidity in epileptic animals, while psychiatric comorbidity aggravates seizures. Epilepsy & Behavior 28:2, pages 232-240.
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Amos D. Korczyn, Steven C. Schachter, Martin J. Brodie, Sarang S. Dalal, Jerome EngelJr.Jr., Alla Guekht, Hrvoje Hecimovic, Karim Jerbi, Andres M. Kanner, Cecilie Johannessen Landmark, Pavel Mares, Petr Marusic, Stefano Meletti, Marco Mula, Philip N. Patsalos, Markus Reuber, Philippe Ryvlin, Klára Štillová, Roberto Tuchman & Ivan Rektor. (2013) Epilepsy, cognition, and neuropsychiatry (Epilepsy, Brain, and Mind, part 2). Epilepsy & Behavior 28:2, pages 283-302.
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Sheridan M. Hoy. (2013) Zonisamide: A Review of Its Use in the Management of Adults with Partial Seizures. Drugs 73:12, pages 1321-1338.
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Marco Mula, Andres M. Kanner, Bettina Schmitz & Steven Schachter. (2013) Antiepileptic drugs and suicidality: An expert consensus statement from the Task Force on Therapeutic Strategies of the ILAE Commission on Neuropsychobiology. Epilepsia 54:1, pages 199-203.
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S. Alisha Epps & David Weinshenker. (2013) Rhythm and blues: Animal models of epilepsy and depression comorbidity. Biochemical Pharmacology 85:2, pages 135-146.
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B. de Toffol. (2013) Troubles psychiatriques de l’épilepsie chez l’adulte. EMC - Psychiatrie 10:1, pages 1-14.
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E. Trinka. (2012) Ideal characteristics of an antiepileptic drug: how do these impact treatment decisions for individual patients?. Acta Neurologica Scandinavica 126, pages 10-18.
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Dag Aurlien, Jan Petter Larsen, Leif Gjerstad & Erik Taubøll. (2012) Comorbid and underlying diseases—Major determinants of excess mortality in epilepsy. Seizure 21:8, pages 573-577.
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Jack J Lin, Marco Mula & Bruce P Hermann. (2012) Uncovering the neurobehavioural comorbidities of epilepsy over the lifespan. The Lancet 380:9848, pages 1180-1192.
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Clare Margaret Eddy, Hugh Edward Rickards & Andrea Eugenio Cavanna. (2012) Behavioral Adverse Effects of Antiepileptic Drugs in Epilepsy. Journal of Clinical Psychopharmacology 32:3, pages 362-375.
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S. D. Walker & R. Kälviäinen. (2011) Non-vision adverse events with vigabatrin therapy. Acta Neurologica Scandinavica 124, pages 72-82.
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