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Diabetes, Metabolic Syndrome and Obesity Volume 9, 2016 - Issue

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Clinical Trial Report

Comparison of efficacy and safety of two starting insulin regimens in non-Asian, Asian Indian, and East Asian patients with type 2 diabetes: a post hoc analysis of the PARADIGM study

Linong Ji1 Department of Endocrinology, Peking University People’s Hospital, Beijing, People’s Republic of China

Kyung Wan Min2 Department of Endocrinology, Eulji Hospital, Seoul, Republic of Korea

Juliana Oliveira3 Eli Lilly and Company, Indianapolis, IN, USA

Thomas Lew4 Eli Lilly and Company, Taipei, Songshan District, TaiwanCorrespondence[email protected]

Ran Duan3 Eli Lilly and Company, Indianapolis, IN, USA

Pages 243-249 | Published online: 09 Aug 2016

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Xiaoyong Yuan, Xiaohui Guo, Junqing Zhang, Xiaolin Dong, Yibing Lu, Wuyan Pang, Shenghong Gu, Elisabeth Niemoeller, Lin Ping, Gaowei Nian & Elisabeth Souhami. (2022) Improved glycaemic control and weight benefit with iGlarLixi versus insulin glargine 100 U/ mL in Chinese people with type 2 diabetes advancing their therapy from basal insulin plus oral antihyperglycaemic drugs: Results from the LixiLan‐L‐CN randomized controlled trial . Diabetes, Obesity and Metabolism 24:11, pages 2182-2191.
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Qi Pan, Yijun Li, Hailong Wan, Junfen Wang, Binhua Xu, Guoping Wang, Chengxia Jiang, Li Liang, Wei Feng, Jingcheng Liu, Ting Wang, Xia Zhang, Nan Cui, Yiming Mu & Lixin Guo. (2022) Efficacy and safety of a basal insulin + 2‐3 oral antihyperglycaemic drugs regimen versus a twice‐daily premixed insulin + metformin regimen after short‐term intensive insulin therapy in individuals with type 2 diabetes: The multicentre, open‐label, randomized controlled BEYOND‐V trial . Diabetes, Obesity and Metabolism 24:10, pages 1957-1966.
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Jian Zhou, Si Chen, Jie Cheng, Jiankun Zhu, Ying Lou, Yuqian Bao & Weiping Jia. (2022) Ultra rapid lispro improves postprandial glucose control versus lispro in combination with insulin glargine/degludec in adults with type 2 diabetes: a prospective, randomized, double-blind, phase 3 trial. Science Bulletin 67:17, pages 1785-1791.
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Jing Liu, Xia Jiang, Binhua Xu, Guoping Wang, Nan Cui, Xia Zhang, Jingcheng Liu, Yiming Mu & Lixin Guo. (2020) Efficacy and Safety of Basal Insulin-Based Treatment Versus Twice-Daily Premixed Insulin After Short-Term Intensive Insulin Therapy in Patients with Type 2 Diabetes Mellitus in China: Study Protocol for a Randomized Controlled Trial (BEYOND V). Advances in Therapy 37:4, pages 1675-1687.
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Anoop MisraMayur PatelPankaj AgarwalSailesh LodhaNikhil TandonMohan MagdumChittaranjan YajnikRomik GhoshAjit Walekar. (2019) Effectiveness and Safety of Physician-Led Versus Patient-Led Titration of Insulin Glargine in Indian Patients with Type 2 Diabetes Mellitus: A Subanalysis of the Asian Treat to Target Lantus Study (ATLAS). Diabetes Technology & Therapeutics 21:11, pages 656-664.
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Viswanathan Mohan, Kyu Jeung Ahn, Young Min Cho, Rakesh Kumar Sahay, Chien-Ning Huang, Sanjay Kalra, Manoj Chadha, Indranil Bhattacharya, So Yeon Kim & Erik Spaepen. (2019) Lilly Insulin Glargine Versus Lantus® in Type 2 Diabetes Mellitus Patients: India and East Asia Subpopulation Analyses of the ELEMENT 5 Study. Clinical Drug Investigation 39:8, pages 745-756.
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Takahisa Hirose, Ching-Chu Chen, Kyu Jeung Ahn & Jacek Kiljański. (2019) Use of Insulin Glargine 100 U/mL for the Treatment of Type 2 Diabetes Mellitus in East Asians: A Review. Diabetes Therapy 10:3, pages 805-833.
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George Dailey, Harpreet S Bajaj, Terry Dex, Melanie Groleau, William Stager & Aaron Vinik. (2019) Post hoc efficacy and safety analysis of insulin glargine/lixisenatide fixed- ratio combination in North American patients compared with the rest of world. BMJ Open Diabetes Research & Care 7:1, pages e000581.
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Robyn K. Pollom, Liza L. Ilag, Lyndon B. Lacaya, Tina M. Morwick & Ramón Ortiz Carrasquillo. (2019) Lilly Insulin Glargine Versus Lantus® in Insulin-Naïve and Insulin-Treated Adults with Type 2 Diabetes: A Randomized, Controlled Trial (ELEMENT 5). Diabetes Therapy 10:1, pages 189-203.
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Xiao-Ling Cai & Li-Nong Ji. (2019) Treatment response between Asian and non-Asian patients with type 2 diabetes. Chinese Medical Journal 132:1, pages 1-3.
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Xiao Mei Zhang, Peng Fei Li, Jia Ning Hou & Li Nong Ji. (2018) Blood glucose profiles in East Asian and Caucasian injection-naive patients with type 2 diabetes inadequately controlled on oral medication: a pooled analysis. Diabetes/Metabolism Research and Reviews 34:8, pages e3062.
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Riccardo Candido, Kathleen Wyne & Ester Romoli. (2018) A Review of Basal-Bolus Therapy Using Insulin Glargine and Insulin Lispro in the Management of Diabetes Mellitus. Diabetes Therapy 9:3, pages 927-949.
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Guang Ning, Tushar Bandgar, Uwe Hehnke, Jisoo Lee & Juliana C. N. Chan. (2017) Efficacy and Safety of Linagliptin in 2681 Asian Patients Stratified by Age, Obesity, and Renal Function: A Pooled Analysis of Randomized Clinical Trials. Advances in Therapy 34:9, pages 2150-2162.
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Wayne H-H Sheu, Linong Ji, Woo Je Lee, Abdul Jabbar, Jeong Hee Han & Thomas Lew. (2017) Efficacy and safety of premixed insulin analogs in Asian patients with type 2 diabetes: A systematic review. Journal of Diabetes Investigation 8:4, pages 518-534.
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Linong Ji, Puhong Zhang, Dongshan Zhu, Xian Li, Jiachao Ji, Juming Lu, Xiaohui Guo, Weiping Jia, Jianping Weng, Yangfeng Wu, Wenying Yang, Dajin Zou, Zhiguang Zhou, Changyu Pan, Yan Gao & Satish K. Garg. (2017) Observational Registry of Basal Insulin Treatment (ORBIT) in patients with type 2 diabetes uncontrolled with oral antihyperglycaemic drugs: Real-life use of basal insulin in China. Diabetes, Obesity and Metabolism 19:6, pages 822-830.
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Comparison of efficacy and safety of two starting insulin regimens in non-Asian, Asian Indian, and East Asian patients with type 2 diabetes: a post hoc analysis of the PARADIGM study

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Comparison of efficacy and safety of two starting insulin regimens in non-Asian, Asian Indian, and East Asian patients with type 2 diabetes: a post hoc analysis of the PARADIGM study

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