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Diabetes, Metabolic Syndrome and Obesity Volume 9, 2016 - Issue

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Original Research

Natural dipeptidyl peptidase-IV inhibitor mangiferin mitigates diabetes- and metabolic syndrome-induced changes in experimental rats

Rajesh Kumar Suman1 Department of PharmacologyCorrespondence[email protected]

Ipseeta Ray Mohanty1 Department of Pharmacology

Ujwala Maheshwari2 Department of Pathology, MGM Medical College, Kamothe, Navi Mumbai, India

Manjusha K Borde1 Department of Pharmacology

YA Deshmukh1 Department of Pharmacology

Pages 261-272 | Published online: 29 Aug 2016

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Mengdi Wang, Yan Liang, Keqi Chen, Maolong Wang, Xuehua Long, HongLing Liu, Yong Sun & Bin He. (2022) The management of diabetes mellitus by mangiferin: advances and prospects. Nanoscale 14:6, pages 2119-2135.
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Ashok Jangra, Mandeep Kumar Arora, Anglina Kisku & Sonal Sharma. (2020) The multifaceted role of mangiferin in health and diseases: a review. Advances in Traditional Medicine 21:4, pages 619-643.
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Lebin Weng, Ting-Hsu Chen, Qingyan Zheng, Wei-Hao Weng, Liyue Huang, Dong Lai, Yaw-Syan Fu & Ching-Feng Weng. (2021) Syringaldehyde promoting intestinal motility with suppressing α-amylase hinders starch digestion in diabetic mice. Biomedicine & Pharmacotherapy 141, pages 111865.
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Saeed Alshahrani, Tarique Anwer, Mohammad Firoz Alam, Rayan A. Ahmed, Gyas Khan, Sivagurunathan Moni Sivakumar, Ambreen Shoaib, Prawez Alam & Faizul Azam. (2021) Effect of thymoquinone on high fat diet and STZ‐induced experimental type 2 diabetes: A mechanistic insight by in vivo and in silico studies. Journal of Food Biochemistry 45:8.
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Sibhghatulla Shaikh, Eun-Ju Lee, Khurshid Ahmad, Syed-Sayeed Ahmad, Jeong-Ho Lim & Inho Choi. (2021) A Comprehensive Review and Perspective on Natural Sources as Dipeptidyl Peptidase-4 Inhibitors for Management of Diabetes. Pharmaceuticals 14:6, pages 591.
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You Wu, Wei Liu, Tao Yang, Mei Li, Lingling Qin, Lili Wu & Tonghua Liu. (2021) Oral administration of mangiferin ameliorates diabetes in animal models: a meta-analysis and systematic review. Nutrition Research 87, pages 57-69.
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Yangyang Chen, Jichun Tang, Yinghong Zhang, Juan Du, Yuanli Wang, Hui Yu & Yanling He. (2020) Astaxanthin alleviates gestational diabetes mellitus in mice through suppression of oxidative stress. Naunyn-Schmiedeberg's Archives of Pharmacology 393:12, pages 2517-2527.
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Sonali Aswal, Ankit Kumar, Ashutosh Chauhan, Ruchi Badoni Semwal, Abhimanyu Kumar & Deepak Kumar Semwal. (2020) A Molecular Approach on the Protective Effects of Mangiferin Against Diabetes and Diabetes-related Complications. Current Diabetes Reviews 16:7, pages 690-698.
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Na Wang, Xiujuan Dong, Dandan Shi, Na Li & Qun Zhang. (2020) Cryptotanshinone ameliorates placental oxidative stress and inflammation in mice with gestational diabetes mellitus. Archives of Pharmacal Research 43:7, pages 755-764.
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Katsuhiro Yoshii, Masako Ogasawara, Jun Wada, Yoshihiro Yamamoto & Kuniyo Inouye. (2020) Exploration of dipeptidyl-peptidase IV (DPP IV) inhibitors in a low-molecular mass extract of the earthworm Eisenia fetida and identification of the inhibitors as amino acids like methionine, leucine, histidine, and isoleucine. Enzyme and Microbial Technology 137, pages 109534.
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Saikat Dewanjee, Pratik Chakraborty, Biswajit Mukherjee & Vincenzo De Feo. (2020) Plant-Based Antidiabetic Nanoformulations: The Emerging Paradigm for Effective Therapy. International Journal of Molecular Sciences 21:6, pages 2217.
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Ana M. Duarte, Maria P. Guarino, Sónia Barroso & Maria M. Gil. (2020) Phytopharmacological Strategies in the Management of Type 2 Diabetes Mellitus. Foods 9:3, pages 271.
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Babalwa U. Jack, Christiaan J. Malherbe, Mokadi Mamushi, Christo J.F. Muller, Elizabeth Joubert, Johan Louw & Carmen Pheiffer. (2019) Adipose tissue as a possible therapeutic target for polyphenols: A case for Cyclopia extracts as anti-obesity nutraceuticals. Biomedicine & Pharmacotherapy 120, pages 109439.
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Po-Kai Huang, Shian-Ren Lin, Jirawat Riyaphan, Yaw-Syan Fu & Ching-Feng Weng. (2019) Polyalthia Clerodane Diterpene Potentiates Hypoglycemia via Inhibition of Dipeptidyl Peptidase 4. International Journal of Molecular Sciences 20:3, pages 530.
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Shian-Ren Lin, Chia-Hsiang Chang, May-Jwan Tsai, Henrich Cheng, Jian-Chyi Chen, Max K. Leong & Ching-Feng Weng. (2019) The perceptions of natural compounds against dipeptidyl peptidase 4 in diabetes: from in silico to in vivo . Therapeutic Advances in Chronic Disease 10, pages 204062231987530.
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Suya Du, Huirong Liu, Tiantian Lei, Xiaofang Xie, Hailian Wang, Xia He, Rongsheng Tong & Yi Wang. (2018) Mangiferin: An effective therapeutic agent against several disorders (Review). Molecular Medicine Reports.
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IR Mohanty, S Kumar & Suman Rajesh. (2017) Dipeptidyl Peptidase IV Inhibitory Activity of Berberine and Mangiferin: An In Silico Approach. International Journal of Clinical Endocrinology and Metabolism 3:1, pages 018-022.
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Carla Horvath, Joëlle Houriet, Caroline Moser, Lucia Balazova, Miroslav Balaz, Hua Dong, Aron Horvath, Vissarion Efthymiou, Adriano Rutz, Laurence Marcourt, Christopher Kitalong, Bertrand Graz, Victor Yano, Emerson Ferreira Queiroz, Jean-Luc Wolfender & Christian Wolfrum. (2021) Genkwanin Glycosides from the Phaleria Nisidai Extract Improve Glucose Homeostasis by Stimulating Insulin-Independent Glucose Uptake. SSRN Electronic Journal.
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Natural dipeptidyl peptidase-IV inhibitor mangiferin mitigates diabetes- and metabolic syndrome-induced changes in experimental rats

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Natural dipeptidyl peptidase-IV inhibitor mangiferin mitigates diabetes- and metabolic syndrome-induced changes in experimental rats

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