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Diabetes, Metabolic Syndrome and Obesity Volume 14, 2021 - Issue
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Original Research

Emodin Ameliorates Renal Damage and Podocyte Injury in a Rat Model of Diabetic Nephropathy via Regulating AMPK/mTOR-Mediated Autophagy Signaling Pathway

Hong Liu1 Department of Nephrology, Wuhan No. 1 Hospital, Wuhan, Hubei, 430022, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0001-8503-9710
ORCID Icon,
Quan Wang1 Department of Nephrology, Wuhan No. 1 Hospital, Wuhan, Hubei, 430022, People’s Republic of China
,
Ge Shi1 Department of Nephrology, Wuhan No. 1 Hospital, Wuhan, Hubei, 430022, People’s Republic of China
,
Wenqiang Yang2 Department of Central Laboratory, Wuhan No. 1 Hospital, Wuhan, Hubei, 430022, People’s Republic of China
,
Yanmin Zhang1 Department of Nephrology, Wuhan No. 1 Hospital, Wuhan, Hubei, 430022, People’s Republic of China
,
Weidong Chen1 Department of Nephrology, Wuhan No. 1 Hospital, Wuhan, Hubei, 430022, People’s Republic of China
,
Sheng Wan1 Department of Nephrology, Wuhan No. 1 Hospital, Wuhan, Hubei, 430022, People’s Republic of China
,
Fei Xiong1 Department of Nephrology, Wuhan No. 1 Hospital, Wuhan, Hubei, 430022, People’s Republic of ChinaCorrespondence[email protected] [email protected]
&
Zengsi Wang1 Department of Nephrology, Wuhan No. 1 Hospital, Wuhan, Hubei, 430022, People’s Republic of China
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Pages 1253-1266 | Published online: 18 Mar 2021

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Xiaoju Ma, Jingru Ma, Tian Leng, Zhongzhu Yuan, Tingting Hu, Qiuyan Liu & Tao Shen. (2023) Advances in oxidative stress in pathogenesis of diabetic kidney disease and efficacy of TCM intervention. Renal Failure 45:1.
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Articles from other publishers (20)

Fang Zhang, Rui Wu, Yanfang Liu, Shu Dai, Xinyan Xue, Yunxia Li & Xiaohong Gong. (2023) Nephroprotective and nephrotoxic effects of Rhubarb and their molecular mechanisms. Biomedicine & Pharmacotherapy 160, pages 114297.
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Yu-Peng Han, Li-Juan Liu, Jia-Lin Yan, Meng-Yuan Chen, Xiang-Fei Meng, Xin-Ru Zhou & Ling-Bo Qian. (2023) Autophagy and its therapeutic potential in diabetic nephropathy. Frontiers in Endocrinology 14.
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HaoShang, Xinhua Jia, Huaman Liu, Xinyue Zhang & Yumeng Shao. (2023) A comprehensive review of emodin in fibrosis treatment. Fitoterapia 165, pages 105358.
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Qi Jin, Tongtong Liu, Danqian Chen, Liping Yang, Huimin Mao, Fang Ma, Yuyang Wang, Ping Li & Yongli Zhan. (2023) Therapeutic potential of artemisinin and its derivatives in managing kidney diseases. Frontiers in Pharmacology 14.
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Moein Ala. (2023) Sestrin2 Signaling Pathway Regulates Podocyte Biology and Protects against Diabetic Nephropathy. Journal of Diabetes Research 2023, pages 1-15.
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Chujun Chen, Zhenming Lin, Wenbin Liu, Qiong Hu, Jie Wang, Xiaoyan Zhuang, Sujuan Guan, Xiaoting Wu, Tingting Hu, Shijian Quan, Xiaobao Jin & Juan Shen. (2022) Emodin accelerates diabetic wound healing by promoting anti-inflammatory macrophage polarization. European Journal of Pharmacology 936, pages 175329.
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Xiujie Shi, Meiying Chang, Mingming Zhao, Yue Shi & Yu Zhang. (2022) Traditional Chinese medicine compounds ameliorating glomerular diseases via autophagy: A mechanism review. Biomedicine & Pharmacotherapy 156, pages 113916.
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Shraddha Singh Raghav, Bhavna Kumar, Neeraj Kumar Sethiya & Ankur Kaul. (2022) A Mechanistic Insight on Phytoconstituents Delivering Hypoglycemic Activity: A Comprehensive Overview. Future Pharmacology 2:4, pages 511-546.
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Tongtong Liu, Qi Jin, Feihong Ren, Liping Yang, Huimin Mao, Fang Ma, Yuyang Wang, Ping Li & Yongli Zhan. (2022) Potential therapeutic effects of natural compounds targeting autophagy to alleviate podocyte injury in glomerular diseases. Biomedicine & Pharmacotherapy 155, pages 113670.
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Hong Liu, Wei-dong Chen, Yang-lin Hu, Wen-qiang Yang, Tao-tao Hu, Huan-lan Wang & Yan-min Zhang. (2022) Emodin Ameliorates High Glucose-Induced Podocyte Apoptosis via Regulating AMPK/mTOR-Mediated Autophagy Signaling Pathway. Chinese Journal of Integrative Medicine.
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Yangyang Wang, Fangwei Yu, Ao Li, Zijia He, Caiyan Qu, Caiying He, Xiao Ma & Huakui Zhan. (2022) The progress and prospect of natural components in rhubarb (Rheum ribes L.) in the treatment of renal fibrosis. Frontiers in Pharmacology 13.
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Zijun Zhou, Yanheng Qiao, Yanru Zhao, Xin Chen, Jie Li, Hanqing Zhang, Qiumei Lan & Bo Yang. (2022) Natural products: potential drugs for the treatment of renal fibrosis. Chinese Medicine 17:1.
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Jiayi Xu, Xiaomeng Shan, Chunwei Chen, Yanbin Gao, Dawei Zou, Xiaolei Wang, Tao Wang & Yimin Shi. (2022) Tangshenning Attenuates High Glucose-Induced Podocyte Injury via Restoring Autophagy Activity through Inhibiting mTORC1 Activation. Journal of Diabetes Research 2022, pages 1-11.
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Ding-Wen Cheng, Yuan-Fen Yue, Chun-Xi Chen, Yin-Di Hu, Qiong Tang, Min Xie, Ling Liu, Dai Li, Hai-Li Zhu & Meng-Lin Cheng. (2022) Emodin alleviates arthritis pain through reducing spinal inflammation and oxidative stress. Molecular Pain 18, pages 174480692211463.
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Tianwen Yao, Wenxiang Su, Shisheng Han, Yan Lu, Yanqiu Xu, Min Chen & Yi Wang. (2022) Recent Advances in Traditional Chinese Medicine for Treatment of Podocyte Injury. Frontiers in Pharmacology 13.
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Hany H. Arab, Ahmed M. Ashour, Ahmed H. Eid, El-Shaimaa A. Arafa, Hana J. Al Khabbaz & Sarah A. Abd El-Aal. (2022) Targeting oxidative stress, apoptosis, and autophagy by galangin mitigates cadmium-induced renal damage: Role of SIRT1/Nrf2 and AMPK/mTOR pathways. Life Sciences 291, pages 120300.
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Hany H. Arab, Sarah A. Abd El-Aal, Ahmed H. Eid, El-Shaimaa A. Arafa, Ayman M. Mahmoud & Ahmed M. Ashour. (2022) Targeting inflammation, autophagy, and apoptosis by troxerutin attenuates methotrexate-induced renal injury in rats. International Immunopharmacology 103, pages 108284.
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Yoong Mond Teh, Siti Aisyah Mualif & Soo Kun Lim. (2022) A comprehensive insight into autophagy and its potential signaling pathways as a therapeutic target in podocyte injury. The International Journal of Biochemistry & Cell Biology 143, pages 106153.
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Miquel Martorell, Natalia Castro, Montserrat Victoriano, Xavier Capó, Silvia Tejada, Sara Vitalini, Raffaele Pezzani & Antoni Sureda. (2021) An Update of Anthraquinone Derivatives Emodin, Diacerein, and Catenarin in Diabetes. Evidence-Based Complementary and Alternative Medicine 2021, pages 1-13.
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Ya-Fei Bai, Chun-Li Wang, Ming-Zhi Xu, Ming-Jiao Pan, Qing-Yi Sun & Ru-Man Chen. (2021) The clinical effectiveness and safety of traditional Chinese medicine uremic clearance granule combined with high-flux hemodialysis in the treatment of uremic pruritus. Medicine 100:25, pages e26423.
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