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Review

GABAergic system in the endocrine pancreas: a new target for diabetes treatment

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Pages 79-87 | Published online: 03 Feb 2015

Keep up to date with the latest research on this topic with citation updates for this article.

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André J. Scheen. (2016) Investigational insulin secretagogues for type 2 diabetes. Expert Opinion on Investigational Drugs 25:4, pages 405-422.
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Articles from other publishers (21)

Kannan Harithpriya, Ravichandran Jayasuriya, Trishla Adhikari, Awantika Rai & Kunka Mohanram Ramkumar. (2023) Modulation of transcription factors by small molecules in β-cell development and differentiation. European Journal of Pharmacology 946, pages 175606.
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Eung-Kwon Pae, Man-Kyo Chung & Ronald M. Harper. (2022) Intermittent Hypoxia Interferes with Autocrine Effects of GABA on Insulin Secretion in Postnatal Rodents—Implications for Pediatric Obstructive Sleep Apnea. Children 9:9, pages 1305.
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Gérald J. Prud’homme, Mervé Kurt & Qinghua Wang. (2022) Pathobiology of the Klotho Antiaging Protein and Therapeutic Considerations. Frontiers in Aging 3.
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Amro Abdelazez, Garsa Alshehry, Eman Algarni, Huda Al Jumayi, Heba Abdel-Motaal & Xiang-Chen Meng. (2022) Postbiotic Gamma-Aminobutyric Acid and Camel Milk Intervention as Innovative Trends Against Hyperglycemia and Hyperlipidemia in Streptozotocin-Induced C57BL/6J Diabetic Mice. Frontiers in Microbiology 13.
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Chigusa Shimizu-Okabe, Shigeki Okada, Shiki Okamoto, Hiroaki Masuzaki & Chitoshi Takayama. (2022) Specific Expression of KCC2 in the α Cells of Normal and Type 1 Diabetes Model Mouse Pancreatic Islets. ACTA HISTOCHEMICA ET CYTOCHEMICA 55:1, pages 47-56.
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Shahla Sohrabipour, Mohammad Reza Sharifi, Mohammadreza Sharifi, Ardeshir Talebi & Nepton Soltani. (2022) Combination Therapy with GABA and MgSO4 Improves Insulin Sensitivity in Type 2 Diabetic Rat. International Journal of Endocrinology 2022, pages 1-11.
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Kevin C. Ling, D. Walker Hagan, Jorge Santini-González & Edward A. Phelps. (2021) Effects of sustained GABA releasing implants on pancreatic islets in mice. Drug Delivery and Translational Research 11:5, pages 2198-2208.
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Luis F. Hernandez, Luis R. Betancourt, Ernesto S. Nakayasu, Charles Ansong, Gerardo A. Ceballos, Daniel Paredes & Midhat H. Abdulreda. (2021) Integrated Metabolomics and Proteomics Analyses in the Local Milieu of Islet Allografts in Rejection versus Tolerance. International Journal of Molecular Sciences 22:16, pages 8754.
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Elizabeth M. Morris, Susanna E. Kitts-Morgan, Dawn M. Spangler, Ibukun M. Ogunade, Kyle R. McLeod & David L. Harmon. (2021) Alteration of the Canine Metabolome After a 3-Week Supplementation of Cannabidiol (CBD) Containing Treats: An Exploratory Study of Healthy Animals. Frontiers in Veterinary Science 8.
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Heny Herawati, Diana Nur Afifah, Eni Kusumanigtyas, Sri Usmiati, Agus S. Soemantri, Miskiyah, Elmi Kamsiati & Muchamad Bachtiar. (2021) Characterization of GABA (gamma-aminobutyric acid) levels some fermented food in Indonesia. IOP Conference Series: Earth and Environmental Science 819:1, pages 012068.
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Erwan Sallard, Diane Letourneur & Pascal Legendre. (2021) Electrophysiology of ionotropic GABA receptors. Cellular and Molecular Life Sciences 78:13, pages 5341-5370.
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Rui Pan, Jian Lou & Ling Wei. (2021) Significant effects of Ganoderma lucidum polysaccharide on lipid metabolism in diabetes may be associated with the activation of the FAM3C‑HSF1‑CAM signaling pathway . Experimental and Therapeutic Medicine 22:2.
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Xenia Simeone, Filip Koniuszewski, Markus Müllegger, Andreas Smetka, Friederike Steudle, Roshan Puthenkalam, Margot Ernst & Petra Scholze. (2021) A Benzodiazepine Ligand with Improved GABA A Receptor α 5-Subunit Selectivity Driven by Interactions with Loop C . Molecular Pharmacology 99:1, pages 39-48.
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Yi-Yin Lee, Cheng-Wei Lin & I-Wen Chen. (2020) Exogenous Insulin Injection-Induced Stiff-Person Syndrome in a Patient With Latent Autoimmune Diabetes: A Case Report and Literature Review. Frontiers in Endocrinology 11.
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Lucía Diez-Gutiérrez, Leire San Vicente, Luis Javier R. Barrón, María del Carmen Villarán & María Chávarri. (2020) Gamma-aminobutyric acid and probiotics: Multiple health benefits and their future in the global functional food and nutraceuticals market. Journal of Functional Foods 64, pages 103669.
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Yuangang Liu, Weiji Weng, Shibin Wang, Ruimin Long, Hanwen Li, Huihui Li, Tengteng Li & Mengyi Wu. (2018) Effect of γ-Aminobutyric Acid–Chitosan Nanoparticles on Glucose Homeostasis in Mice. ACS Omega 3:3, pages 2492-2497.
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Yawen Zeng, Xiaoying Pu, Jiazhen Yang, Juan Du, Xiaomeng Yang, Xia Li, Ling Li, Yan Zhou & Tao Yang. (2018) Preventive and Therapeutic Role of Functional Ingredients of Barley Grass for Chronic Diseases in Human Beings. Oxidative Medicine and Cellular Longevity 2018, pages 1-15.
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Wenjuan Liu, Dong Ok Son, Harry K. Lau, Yinghui Zhou, Gerald J. Prud’homme, Tianru Jin & Qinghua Wang. (2017) Combined Oral Administration of GABA and DPP-4 Inhibitor Prevents Beta Cell Damage and Promotes Beta Cell Regeneration in Mice. Frontiers in Pharmacology 8.
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Daniel M. Linares, Silvia Arboleya, R. Paul Ross & Catherine Stanton. (2017) Complete Genome Sequence of the Gamma-Aminobutyric Acid-Producing Strain Streptococcus thermophilus APC151. Genome Announcements 5:17.
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Daniel M. Linares, Tom F. O’Callaghan, Paula M. O’Connor, R. P. Ross & Catherine Stanton. (2016) Streptococcus thermophilus APC151 Strain Is Suitable for the Manufacture of Naturally GABA-Enriched Bioactive Yogurt. Frontiers in Microbiology 7.
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Xueyan ZhouQiuxiang ZhuXiaowen HanRenguo ChenYaowu LiuHongbin FanXiaoxing Yin. (2015) Quantitative-profiling of neurotransmitter abnormalities in the disease progression of experimental diabetic encephalopathy rat. Canadian Journal of Physiology and Pharmacology 93:11, pages 1007-1013.
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