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Original Research

Clinical role of a fixed combination of standardized Berberis aristata and Silybum marianum extracts in diabetic and hypercholesterolemic patients intolerant to statins

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Pages 89-96 | Published online: 04 Feb 2015

Keep up to date with the latest research on this topic with citation updates for this article.

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Muhmmad Nadeem Akhtar, Rabia Saeed, Farhan Saeed, Aasma Asghar, Samia Ghani, Huda Ateeq, Aftab Ahmed, Amara Rasheed, Muhammad Afzaal, Marwa Waheed, Bilal Hussain & Mohd Asif Shah. (2023) Silymarin: a review on paving the way towards promising pharmacological agent. International Journal of Food Properties 26:1, pages 2256-2272.
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Francesco Di Pierro, Pietro Putignano, Tarcisio Ferrara, Carmela Raiola, Giuliana Rapacioli & Nicola Villanova. (2017) Retrospective analysis of the effects of a highly standardized mixture of Berberis aristata, Silybum marianum, and monacolins K and KA in patients with dyslipidemia. Clinical Pharmacology: Advances and Applications 9, pages 1-7.
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Engi Abdel-Hady Algharably, Iris Filler, Stephanie Rosenfeld, Katja Grabowski & Reinhold Kreutz. (2017) Statin intolerance – a question of definition. Expert Opinion on Drug Safety 16:1, pages 55-63.
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M. A. Lieshchova & V. V. Brygadyrenko. (2023) Effect of Echinacea purpurea and Silybum marianum seeds on the body of rats with an excessive fat diet. Biosystems Diversity 31:1, pages 90-99.
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Mustafa YAŞAR, Güliz SARAÇ, Ali GÖK, Nisa SİPAHİ & Aydan Fülden AĞAN. (2022) Investigation of the Acute Subacute Toxicity of KL-21® Supplementary Food Product in Rats. International Journal of Traditional and Complementary Medicine Research 3:3, pages 190-196.
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Giuseppe Derosa, Angela D'Angelo & Pamela Maffioli. (2022) The role of selected nutraceuticals in management of prediabetes and diabetes: An updated review of the literature. Phytotherapy Research 36:10, pages 3709-3765.
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Fatemeh Mohtashaminia, Mohammad Reza Amini, Fatemeh Sheikhhossein, Kurosh Djafarian & Sakineh Shab-Bidar. (2022) Effects berberine–silymarin on liver enzymes: A systematic review and meta-analysis of randomized controlled trials. Clinical Nutrition ESPEN 49, pages 181-186.
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Vittoria Infantino, Antonella Riva, Giovanna Petrangolini, Pietro Allegrini, Simone Perna, Giancarlo Iannello, Gabriella Peroni, Clara Gasparri & Mariangela Rondanelli. (2022) The Use of Berberine in Diabetes and Metabolic Syndrome: Two Sides of the Same Coin. A Bibliometric Analysis. Current Nutrition & Food Science 18:3, pages 240-247.
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Michalina Mróz, Katarzyna Pastusiak & Paweł Bogdański. (2021) Potencjalne możliwości wykorzystania berberyny w przeciwdziałaniu insulinooporności i w cukrzycy typu 2. Postępy Higieny i Medycyny Doświadczalnej 75:1, pages 790-801.
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Mariangela Rondanelli, Antonella Riva, Giovanna Petrangolini, Pietro Allegrini, Attilio Giacosa, Teresa Fazia, Luisa Bernardinelli, Clara Gasparri, Gabriella Peroni & Simone Perna. (2021) Berberine Phospholipid Is an Effective Insulin Sensitizer and Improves Metabolic and Hormonal Disorders in Women with Polycystic Ovary Syndrome: A One-Group Pretest–Post-Test Explanatory Study. Nutrients 13:10, pages 3665.
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Laili Ding, Shufeng Li, Fan Wang, Jian Xu, Shaojun Li, Bo Wang, Junjie Kou, Yongshun Wang & Wei Cao. (2021) Berberine improves dietary-induced cardiac remodeling by upregulating Kruppel-like factor 4-dependent mitochondrial function. Biological Chemistry 402:7, pages 795-803.
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Bhanu Malhotra, Giriraj T. Kulkarni, Neerupma Dhiman, D.D. Joshi, Subhash Chander, Amit Kharkwal, Arun K. Sharma & Harsha Kharkwal. (2021) Recent advances on Berberis aristata emphasizing berberine alkaloid including phytochemistry, pharmacology and drug delivery system. Journal of Herbal Medicine 27, pages 100433.
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Farzaneh Barzkar, Hamid Reza Baradaran, Mohammad Ebrahim Khamseh, Roya Vesal Azad, Jalil Koohpayehzadeh & Yousef Moradi. (2020) Medicinal plants in the adjunctive treatment of patients with type-1 diabetes: a systematic review of randomized clinical trials. Journal of Diabetes & Metabolic Disorders 19:2, pages 1917-1929.
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Tarun Belwal, Aarti Bisht, Hari Prasad Devkota, Hammad Ullah, Haroon Khan, Aseesh Pandey, Indra Dutt Bhatt & Javier Echeverría. (2020) Phytopharmacology and Clinical Updates of Berberis Species Against Diabetes and Other Metabolic Diseases. Frontiers in Pharmacology 11.
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Alexander BertuccioliSara MoricoliStefano AmatoriMarco Bruno Luigi RocchiGiorgia ViciDavide Sisti. (2020) Berberine and Dyslipidemia: Different Applications and Biopharmaceutical Formulations Without Statin-Like Molecules—A Meta-Analysis. Journal of Medicinal Food 23:2, pages 101-113.
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Elnaz Rezaeiamiri, Roodabeh Bahramsoltani & Roja Rahimi. (2020) Plant-derived natural agents as dietary supplements for the regulation of glycosylated hemoglobin: A review of clinical trials. Clinical Nutrition 39:2, pages 331-342.
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M. Rondanelli, Vittoria Infantino, A. Riva, G. Petrangolini, M. A. Faliva, G. Peroni, M. Naso, M. Nichetti, D. Spadaccini, C. Gasparri & S. Perna. (2020) Polycystic ovary syndrome management: a review of the possible amazing role of berberine. Archives of Gynecology and Obstetrics 301:1, pages 53-60.
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Shahid AkbarShahid Akbar. 2020. Handbook of 200 Medicinal Plants. Handbook of 200 Medicinal Plants 421 428 .
Eleni Pappa, Christos V. Rizos, Theodosios D. Filippatos & Moses S. Elisaf. (2019) Emerging Fixed-Dose Combination Treatments for Hyperlipidemia. Journal of Cardiovascular Pharmacology and Therapeutics 24:4, pages 315-322.
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Vahid Soleimani, Parisa Sadat Delghandi, Seyed Adel Moallem & Gholamreza Karimi. (2019) Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review. Phytotherapy Research 33:6, pages 1627-1638.
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Atefeh Tajmohammadi, Bibi Marjan Razavi & Hossein Hosseinzadeh. (2018) Silybum marianum (milk thistle) and its main constituent, silymarin, as a potential therapeutic plant in metabolic syndrome: A review . Phytotherapy Research 32:10, pages 1933-1949.
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Maryam Vahabzadeh, Nafise Amiri & Gholamreza Karimi. (2018) Effects of silymarin on metabolic syndrome: a review. Journal of the Science of Food and Agriculture 98:13, pages 4816-4823.
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Maciej Banach, Angelo Maria Patti, Rosaria Vincenza Giglio, Arrigo F.G. Cicero, Atanas G. Atanasov, Gani Bajraktari, Eric Bruckert, Olivier Descamps, Dragan M. Djuric, Marat Ezhov, Zlatko Fras, Stephan von Haehling, Niki Katsiki, Michel Langlois, Gustavs Latkovskis, G.B. John Mancini, Dimitri P. Mikhailidis, Olena Mitchenko, Patrick M. Moriarty, Paul Muntner, Dragana Nikolic, Demosthenes B. Panagiotakos, Gyorgy Paragh, Bernhard Paulweber, Daniel Pella, Christos Pitsavos, Željko Reiner, Giuseppe M.C. Rosano, Robert S. Rosenson, Jacek Rysz, Amirhossein Sahebkar, Maria-Corina Serban, Dragos Vinereanu, Michal Vrablík, Gerald F. Watts, Nathan D. Wong & Manfredi Rizzo. (2018) The Role of Nutraceuticals in Statin Intolerant Patients. Journal of the American College of Cardiology 72:1, pages 96-118.
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Yu-Yu Jiang, Han-Ming Cui, Jia-Long Wang, Hui Liu, Meng-Meng Dang, Qiu-Yan Zhang, Fang Yang, Jian-Tao Kou & Xiao-Lin Tong. (2017) Protective role of berberine and Coptischinensis extract on T2MD rats and associated islet Rin-5f cells. Molecular Medicine Reports 16:5, pages 6981-6991.
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Arrigo F.G. Cicero & Alessandro Colletti. (2016) Combinations of phytomedicines with different lipid lowering activity for dyslipidemia management: The available clinical data. Phytomedicine 23:11, pages 1113-1118.
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Birgit Waltenberger, Andrei Mocan, Karel Šmejkal, Elke Heiss & Atanas Atanasov. (2016) Natural Products to Counteract the Epidemic of Cardiovascular and Metabolic Disorders. Molecules 21:6, pages 807.
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Wenguang Chang, Li Chen & Grant M. Hatch. (2016) Berberine treatment attenuates the palmitate-mediated inhibition of glucose uptake and consumption through increased 1,2,3-triacyl-sn-glycerol synthesis and accumulation in H9c2 cardiomyocytes. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1861:4, pages 352-362.
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Chang-Shun Liu, Yu-Rong Zheng, Ying-Feng Zhang & Xiao-Ying Long. (2016) Research progress on berberine with a special focus on its oral bioavailability. Fitoterapia 109, pages 274-282.
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Angela Pirillo & Alberico Luigi Catapano. (2015) Berberine, a plant alkaloid with lipid- and glucose-lowering properties: From in vitro evidence to clinical studies. Atherosclerosis 243:2, pages 449-461.
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Giuseppina Guarino, Teresa Della Corte, Morena Sofia, Lucia Carbone, Giampiero Marino, Emilia Martedì & Sandro Gentile. (2015) Metabolic effects of the association Berberis aristata/Silybum marianum: a preliminary double-blind, placebo-controlled study in obese patients with type 2 diabetes. Nutrafoods 14:4, pages 181-188.
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