Lixisenatide accelerates restoration of normoglycemia and improves human beta-cell function and survival in diabetic immunodeficient NOD–scid IL-2rg^null RIP-DTR mice engrafted with human islets

Chaoxing Yang1 Program in Molecular Medicine, Diabetes Center of Excellence, University of Massachusetts Medical School, Worcester, MA, USA

Matthias Loehn2 Sanofi-Aventis, Diabetes Division, Frankfurt, Germany

Agata Jurczyk1 Program in Molecular Medicine, Diabetes Center of Excellence, University of Massachusetts Medical School, Worcester, MA, USA

Natalia Przewozniak1 Program in Molecular Medicine, Diabetes Center of Excellence, University of Massachusetts Medical School, Worcester, MA, USA

Linda Leehy1 Program in Molecular Medicine, Diabetes Center of Excellence, University of Massachusetts Medical School, Worcester, MA, USA

Pedro L Herrera3 University of Geneva, Geneva, Switzerland

Leonard D Shultz4 The Jackson Laboratory, Bar Harbor, ME, USA

Dale L Greiner1 Program in Molecular Medicine, Diabetes Center of Excellence, University of Massachusetts Medical School, Worcester, MA, USA

David M Harlan5 Department of Medicine, Diabetes Center of Excellence, University of Massachusetts Medical School, Worcester, MA, USA

Rita Bortell1 Program in Molecular Medicine, Diabetes Center of Excellence, University of Massachusetts Medical School, Worcester, MA, USACorrespondence[email protected]

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Lixisenatide accelerates restoration of normoglycemia and improves human beta-cell function and survival in diabetic immunodeficient NOD–scid IL-2rg^null RIP-DTR mice engrafted with human islets

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Lixisenatide accelerates restoration of normoglycemia and improves human beta-cell function and survival in diabetic immunodeficient NOD–scid IL-2rgnull RIP-DTR mice engrafted with human islets

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Lixisenatide accelerates restoration of normoglycemia and improves human beta-cell function and survival in diabetic immunodeficient NOD–scid IL-2rg^null RIP-DTR mice engrafted with human islets