2,630
Views
51
CrossRef citations to date
0
Altmetric
Review

Antimalarial Drug Resistance and Novel Targets for Antimalarial Drug Discovery

, ORCID Icon & ORCID Icon
Pages 4047-4060 | Published online: 10 Nov 2020

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (10)

Muluemebet Fikadu & Ephrem Ashenafi. (2023) Malaria: An Overview. Infection and Drug Resistance 16, pages 3339-3347.
Read now
Loeki Enggar Fitri, Aulia Rahmi Pawestri, Nuning Winaris, Agustina Tri Endharti, Alif Raudhah Husnul Khotimah, Hafshah Yasmina Abidah & John Thomas Rayhan Huwae. (2023) Antimalarial Drug Resistance: A Brief History of Its Spread in Indonesia. Drug Design, Development and Therapy 17, pages 1995-2010.
Read now
Malita Sarma, Mohnad Abdalla, James H. Zothantluanga, Felwa Abdullah Thagfan, Abd. Kakhar Umar, Dipak Chetia, Taghreed N. Almanaa & Samia T. Al-Shouli. (2023) Multi-target molecular dynamic simulations reveal glutathione-S-transferase as the most favorable drug target of knipholone in Plasmodium falciparum. Journal of Biomolecular Structure and Dynamics 41:22, pages 12808-12824.
Read now
Pinky Gehlot & Vivek K. Vyas. (2023) Recent advances on patents of Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitors as antimalarial agents. Expert Opinion on Therapeutic Patents 33:9, pages 579-596.
Read now
Alagesan Karthika, Nagarajan Hemavathy, Mathimaran Amala, Sundaraj Rajamanikandan, Malaisamy Veerapandian, Dhamodharan Prabhu, Umashankar Vetrivel, Chun Jung Cheng, Chitra Jeyaraj Pandian & Jeyaraman Jeyakanthan. (2023) Structural and functional characterization of 6-phosphogluconate dehydrogenase in Plasmodium falciparum (3D7) and identification of its potent inhibitors. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-17.
Read now
Biswajit Naik, Nidhi Gupta, Priya Godara, Varshita Srivastava, Prateek Kumar, Rajanish Giri, Vijay Kumar Prajapati, Kailash C. Pandey & Dhaneswar Prusty. (2023) Structure-based virtual screening approach reveals natural multi-target compounds for the development of antimalarial drugs to combat drug resistance. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-25.
Read now
Walaa Ibraheem, Alaa A. Makki & Abdulrahim Altoam Alzain. (2023) Phthalide derivatives as dihydrofolate reductase inhibitors for malaria: molecular docking and molecular dynamics studies. Journal of Biomolecular Structure and Dynamics 41:11, pages 5127-5137.
Read now
Ashmita Saha, Ayesha Aktar Khanam Choudhury, Nayana Adhikari, Surajit Kumar Ghosh, Anshul Shakya, Saurav Jyoti Patgiri, Udaya Pratap Singh & Hans Raj Bhat. (2023) Molecular docking and antimalarial evaluation of hybrid para-aminobenzoic acid 1,3,5 triazine derivatives via inhibition of Pf-DHFR. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-15.
Read now
Sara Consalvi, Chiara Tammaro, Federico Appetecchia, Mariangela Biava & Giovanna Poce. (2022) Malaria transmission blocking compounds: a patent review. Expert Opinion on Therapeutic Patents 32:6, pages 649-666.
Read now
Hamid Rashidzadeh, Seyed Jamal Tabatabaei Rezaei, Seyed Masih Adyani, Morteza Abazari, Samaneh Rahamooz Haghighi, Hossien Abdollahi & Ali Ramazani. (2021) Recent advances in targeting malaria with nanotechnology-based drug carriers. Pharmaceutical Development and Technology 26:8, pages 807-823.
Read now

Articles from other publishers (41)

Patil Shivprasad Suresh, Veerbhan Kesarwani, Surekha Kumari, Ravi Shankar & Upendra Sharma. (2023) Bisbenzylisoquinolines from Cissampelos pareira L. as antimalarial agents: Molecular docking, pharmacokinetics analysis, and molecular dynamic simulation studies. Computational Biology and Chemistry 104, pages 107826.
Crossref
Chander, Monika, Pawan K. Sharma & Sita Ram. (2023) Recent advances in triazole-benzenesulfonamide hybrids and their biological activities. Medicinal Chemistry Research 32:5, pages 777-801.
Crossref
Jeevan Patra, Devika Rana, Smriti Arora, Mintu Pal & Neeraj Mahindroo. (2023) Falcipains: Biochemistry, target validation and structure-activity relationship studies of inhibitors as antimalarials. European Journal of Medicinal Chemistry 252, pages 115299.
Crossref
Alvi K. WardaniSafwan SafwanNi P. HapsariIrmatika HendriyaniMuhammad T. RidwansyahAbdul R. Wahid. (2023) Antimalarial Activity of Ethyl Acetate and n-Hexane Fractions of Ashitaba Leaves (Angelica keiskei K.). Research Journal of Pharmacy and Technology, pages 1314-1318.
Crossref
Chen Wang, Leiye Yu, Jiying Zhang, Yanxia Zhou, Bo Sun, Qingjie Xiao, Minhua Zhang, Huayi Liu, Jinhong Li, Jialu Li, Yunzi Luo, Jie Xu, Zhong Lian, Jingwen Lin, Xiang Wang, Peng Zhang, Li Guo, Ruobing Ren & Dong Deng. (2023) Structural basis of the substrate recognition and inhibition mechanism of Plasmodium falciparum nucleoside transporter PfENT1. Nature Communications 14:1.
Crossref
Anamika Sharma, Bhavana Singh Chauhan, Kanchan Yadav, Neil Roy Chaudhary, H. Shabeer Ali, Prince Joshi, Salique H. Shaham & Renu Tripathi. (2023) Molecular and immunological characterization of the calcyclin binding protein in rodent malaria parasite. Experimental Parasitology 246, pages 108475.
Crossref
Nyiang Kennet Nkungli, Aymard Didier Tamafo Fouegue, Stanley Numbonui Tasheh, Fritzgerald Kogge Bine, Abrar Ul Hassan & Julius Numbonui Ghogomu. (2023) In silico investigation of falcipain-2 inhibition by hybrid benzimidazole-thiosemicarbazone antiplasmodial agents: A molecular docking, molecular dynamics simulation, and kinetics study. Molecular Diversity.
Crossref
Marjan Talebi, Saeed Samarghandian, Tahereh Farkhondeh & Mohsen Talebi. 2023. Natural Products in Vector-Borne Disease Management. Natural Products in Vector-Borne Disease Management 201 221 .
Benjamin J. Sawyer, Md Imdadul H. Khan & Hoang V. Le. 2023. Medicinal Chemistry of Chemotherapeutic Agents. Medicinal Chemistry of Chemotherapeutic Agents 363 396 .
Amresh Kumar Singh, Suraiya Khanam Ansari, Alok Raghav & Vivek Gaur. 2023. Pathobiology of Parasitic Protozoa: Dynamics and Dimensions. Pathobiology of Parasitic Protozoa: Dynamics and Dimensions 45 60 .
Elias Adikwu, Simeon Ajeka Igono & Nwakaego O Ebong. (2022) Antimalarial evaluation of tamoxifen: a study in parasitized mice. Pharmacy & Pharmacology International Journal 10:6, pages 234-237.
Crossref
Nicholas S. Nieto, Eric E. Parrott & Scott W. Nelson. (2022) Ribonucleotide Misincorporation and Reverse Transcriptase Activities of Plasmodium falciparum Apicoplast DNA Polymerase . Biochemistry 61:23, pages 2742-2750.
Crossref
Thuy-Tien Thi Trinh, Su-Yeon Yun, Gum-Ju Bae, Kwonmo Moon, Hyelee Hong, Tae Hui Eum, Young-ah Kim, Soon-Ai Kim, Hyun Park, Hak Sung Kim & Seon-Ju Yeo. (2022) Anti-malarial activity of HCl salt of SKM13 (SKM13-2HCl). International Journal for Parasitology: Drugs and Drug Resistance 20, pages 113-120.
Crossref
Francisco A. Santos, Gabriela S. Cruz, Filipe A. Vieira, Bruno R.S. Queiroz, Cleverson D.T. Freitas, Felipe P. Mesquita & Pedro F.N. Souza. (2022) Systematic review of antiprotozoal potential of antimicrobial peptides. Acta Tropica 236, pages 106675.
Crossref
Hataichanok Chuljerm, Supawadee Maneekesorn, Chuchard Punsawad, Voravuth Somsak, Yongmin Ma, Jetsada Ruangsuriya, Somdet Srichairatanakool & Pimpisid Koonyosying. (2022) Deferiprone−Resveratrol Hybrid, an Iron-Chelating Compound, Acts as an Antimalarial and Hepatoprotective Agent in Plasmodium berghei-Infected Mice. Bioinorganic Chemistry and Applications 2022, pages 1-12.
Crossref
Ivan Bassanini, Silvia Parapini, Nicoletta Basilico, Donatella Taramelli & Sergio Romeo. (2022) From DC18 to MR07: A Metabolically Stable 4,4′‐Oxybisbenzoyl Amide as a Low‐Nanomolar Growth Inhibitor of P. falciparum . ChemMedChem 17:21.
Crossref
Keerthy Reghunandanan & Rajesh Chandramohanadas. (2022) Chemically induced phenotypes during the blood stage development of Plasmodium falciparum as indicators of the drug mode of action. Frontiers in Drug Discovery 2.
Crossref
Suraj N. Mali & Anima Pandey. (2022) Recent Developments in Medicinal and In Silico Applications of Imidazopyridine Derivatives: Special Emphasis on Malaria, Trypanosomiasis, and Tuberculosis. Chemistry Africa 5:5, pages 1215-1236.
Crossref
Temitope Deborah Olaniyi. (2022) Antiplasmodial evaluation of aqueous extract of Blighia sapida K.D. Koenig leaves in Plasmodium berghei (NK65)-infected mice. Beni-Suef University Journal of Basic and Applied Sciences 11:1.
Crossref
Pitchayathida Mee-udorn, Bodee Nutho, Romchalee Chootrakool, Somchart Maenpuen, Ubolsree Leartsakulpanich, Penchit Chitnumsub & Thanyada Rungrotmongkol. (2022) Structural dynamics and in silico design of pyrazolopyran-based inhibitors against Plasmodium serine hydroxymethyltransferases. Journal of Molecular Liquids 362, pages 119737.
Crossref
Jasmita Gill & Amit Sharma. (2022) Genomic analysis of single nucleotide polymorphisms in malaria parasite drug targets. Parasites & Vectors 15:1.
Crossref
James Abugri, Joseph Ayariga, Samuel Sunyazi Sunwiale, Cletus Adiyaga Wezena, Julien Agyemang Gyamfi, Michael Adu-Frimpong, Godfred Agongo, Julius Tieroyaare Dongdem, Daniel Abugri & Bismarck Dinko. (2022) Targeting the Plasmodium falciparum proteome and organelles for potential antimalarial drug candidates. Heliyon 8:8, pages e10390.
Crossref
Phuong Thuy Viet Nguyen, Giang Le Tra Nguyen, Oanh Thi Đinh, Cuong Quoc Duong, Lam H. Nguyen & Thanh N. Truong. (2022) In search of suitable protein targets for anti-malarial and anti-dengue drug discovery. Journal of Molecular Structure 1256, pages 132520.
Crossref
Anil Kumar Marapaka, Priyanka Sankoju, Guozhen Zhang, Yongzheng Ding, Chunhua Ma, Vijaykumar Pillalamarri, Renu Sudhakar, Bharati Reddi, Puran Singh Sijwali, Yingjie Zhang & Anthony Addlagatta. (2022) Development of peptidomimetic hydroxamates as PfA-M1 and PfA-M17 dual inhibitors: Biological evaluation and structural characterization by cocrystallization. Chinese Chemical Letters 33:5, pages 2550-2554.
Crossref
Minyahil Tadesse Boltena, Ziad El-Khatib, Abraham Sahilemichael Kebede, Benedict Oppong Asamoah, Appiah Seth Christopher Yaw, Kassim Kamara, Phénix Constant Assogba, Andualem Tadesse Boltena, Hawult Taye Adane, Elifaged Hailemeskel & Mulatu Biru. (2022) Malaria and Helminthic Co-Infection during Pregnancy in Sub-Saharan Africa: A Systematic Review and Meta-Analysis. International Journal of Environmental Research and Public Health 19:9, pages 5444.
Crossref
Godfrey Manirakiza, Kennedy Kassaza, Ivan Mugisha Taremwa, Joel Bazira & Fredrick Byarugaba. (2022) Molecular identification and anti-malarial drug resistance profile of Plasmodium falciparum from patients attending Kisoro Hospital, southwestern Uganda. Malaria Journal 21:1.
Crossref
Lovepreet Singh, Diana Fontinha, Denise Francisco, Miguel Prudêncio & Kamaljit Singh. (2022) Synthesis and antiplasmodial activity of regioisomers and epimers of second-generation dual acting ivermectin hybrids. Scientific Reports 12:1.
Crossref
Francis O. Atanu, Damilare Rotimi, Omotayo B. Ilesanmi, Jamila S. Al Malki, Gaber E. Batiha & Precious A. Idakwoji. (2022) Hydroethanolic Extracts of Senna alata Leaves Possess Antimalarial Effects and Reverses Haematological and Biochemical Pertubation in Plasmodium berghei -infected Mice . Journal of Evidence-Based Integrative Medicine 27, pages 2515690X2211164.
Crossref
Euclides Nenga Manuel Sacomboio, Cruz S Sebastião, Jurema Luzia Francisco Antonio, Álvaro Kuanzambi Vezo, Daisy Viviana Sebastião Bapolo & Joana Morais. (2022) Factors Associated With Resistance to In-Hospital Treatment of Malaria in Angolan Patients. Infectious Diseases: Research and Treatment 15, pages 117863372210768.
Crossref
Anna Jaromin, Beata Gryzło, Marek Jamrozik, Silvia Parapini, Nicoletta Basilico, Marek Cegła, Donatella Taramelli & Agnieszka Zagórska. (2021) Synthesis, Molecular Docking and Antiplasmodial Activities of New Tetrahydro-β-Carbolines. International Journal of Molecular Sciences 22:24, pages 13569.
Crossref
Haipin Zhou, Zihan Rui, Yiming Yang, Shengtao Xu, Yutian Shao & Long Liu. (2021) First total synthesis of hoshinoamide A. Beilstein Journal of Organic Chemistry 17, pages 2924-2931.
Crossref
Chinedu Ogbonnia Egwu, Jean-Michel Augereau, Karine Reybier & Françoise Benoit-Vical. (2021) Reactive Oxygen Species as the Brainbox in Malaria Treatment. Antioxidants 10:12, pages 1872.
Crossref
Natalya N. Besednova, Tatyana S. Zaporozhets, Boris G. Andryukov, Sergey P. Kryzhanovsky, Svetlana P. Ermakova, Tatyana A. Kuznetsova, Anastasia N. Voronova & Mikhail Y. Shchelkanov. (2021) Antiparasitic Effects of Sulfated Polysaccharides from Marine Hydrobionts. Marine Drugs 19:11, pages 637.
Crossref
Dejen Nureye. 2021. Plasmodium Species and Drug Resistance. Plasmodium Species and Drug Resistance.
Bathini Thissera, Irene Hallyburton, Che Julius Ngwa, Hafsa Cherif-Silini, Ahmed S.I. Hassane, Mark Anderson, Lorna A. Campbell, Nicole Mutter, Manal Eshelli, Usama R. Abdelmohsen, Mohammed Yaseen, Gabriele Pradel, Lassaad Belbahri, Bahaa Elgendy, Lamees Hegazy & Mostafa E. Rateb. (2021) Potent antiplasmodial alkaloids from the rhizobacterium Pantoea agglomerans as hemozoin modulators. Bioorganic Chemistry 115, pages 105215.
Crossref
Mohammad Murwih Alidmat, Melati Khairuddean, Naziera Mohammad Norman, Anis Nasihah Mohamed Asri, Mohd Hisyam Mohd Suhaimi & Garima Sharma. (2021) Synthesis, characterization, docking study and biological evaluation of new chalcone, pyrazoline, and pyrimidine derivatives as potent antimalarial compounds. Arabian Journal of Chemistry 14:9, pages 103304.
Crossref
Verrill M. NorwoodIVIV, Claribel Murillo-Solano, Michael G. GoertzenIIII, Beau R. Brummel, David L. Perry, James R. Rocca, Debopam Chakrabarti & Robert William HuigensIIIIII. (2021) Ring Distortion of Vincamine Leads to the Identification of Re-Engineered Antiplasmodial Agents. ACS Omega 6:31, pages 20455-20470.
Crossref
Duc Hoàng Lande, Abed Nasereddin, Arne Alder, Tim W. Gilberger, Ron Dzikowski, Johann Grünefeld & Conrad Kunick. (2021) Synthesis and Antiplasmodial Activity of Bisindolylcyclobutenediones. Molecules 26:16, pages 4739.
Crossref
Mohammad Al-Awadhi, Suhail Ahmad & Jamshaid Iqbal. (2021) Current Status and the Epidemiology of Malaria in the Middle East Region and Beyond. Microorganisms 9:2, pages 338.
Crossref
Ishan Wadi, Nimita Deora, Mahendra Nath & Abhinav Sinha. (2021) Investigation of factors affecting the production of P. falciparum gametocytes in an Indian isolate. 3 Biotech 11:2.
Crossref
Fatoumata Gniné Fofana, Ayoub Ksouri, Cheickna Cisse, Oussema Souiai, Alia Benkahla, Mamadou Sangare, Jeffrey G. Shaffer, Seydou O. Doumbia & Mamadou Wele. (2022) Docking of Human Band 3 Anion Transporter Proteins with Their Plasmodium Falciparum Interactors Based on Short Linear Motifs. SSRN Electronic Journal.
Crossref