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Review

Community-acquired Clostridium difficile infection: an increasing public health threat

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Pages 63-72 | Published online: 17 Mar 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (8)

Maria Klezovich-Bénard, Frédérique Bouchand, Elisabeth Rouveix, Pierre L. Goossens & Benjamin Davido. (2021) Management and characteristics of patients suffering from Clostridiodes difficile infection in primary care. European Journal of General Practice 27:1, pages 320-325.
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Vo Van Giau, Hyon Lee, Seong Soo A An & John Hulme. (2019) Recent advances in the treatment of C. difficile using biotherapeutic agents. Infection and Drug Resistance 12, pages 1597-1615.
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Raseen Tariq, Dhruvika Mukhija, Arjun Gupta, Siddharth Singh, Darrell S Pardi & Sahil Khanna. (2018) Statin use and the risk of Clostridium difficile infection: a systematic review with meta-analysis. Infection and Drug Resistance 11, pages 405-416.
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Lee-Anne Godinho & Charles Feldman. (2018) Clostridium difficile infection in Johannesburg, South Africa. Hospital Practice 46:5, pages 287-294.
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Omar Abughanimeh, Ayman Qasrawi, Osama Kaddourah, Laith Al Momani & Mouhanna Abu Ghanimeh. (2018) Clostridium difficile infection in oncology patients: epidemiology, pathophysiology, risk factors, diagnosis, and treatment. Hospital Practice 46:5, pages 266-277.
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Kathryn A Bowman, Elizabeth K Broussard & Christina M Surawicz. (2015) Fecal microbiota transplantation: current clinical efficacy and future prospects. Clinical and Experimental Gastroenterology 8, pages 285-291.
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Grace S Crowther & Mark H Wilcox. (2015) Antibiotic therapy and Clostridium difficile infection – primum non nocere – first do no harm. Infection and Drug Resistance 8, pages 333-337.
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Guglielmo Borgia, Alberto Enrico Maraolo, Maria Foggia, Antonio Riccardo Buonomo & Ivan Gentile. (2015) Fecal microbiota transplantation for Clostridium difficile infection: back to the future. Expert Opinion on Biological Therapy 15:7, pages 1001-1014.
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Articles from other publishers (27)

Ariana Saatchi, Sungeun Kim & Fawziah Marra. (2023) Retrospective Cohort Analysis of Outpatient Antibiotic Use for Clostridioides difficile-Indicated Agents in British Columbia, from 2000 to 2018. Canadian Journal of Infectious Diseases and Medical Microbiology 2023, pages 1-8.
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Amr Salah Omar, Adel Taha, Praveen Cherukanathundiyil Sivadasan, Mohamed Abadelhamid Khalil & Tamer Elmetwally Farhat. (2023) Nosocomial Diarrhea in Intensive Care Units: A Mortality-Based Bacteriological Study. Journal of Medical Sciences 23:1, pages 32-37.
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Sh. V. Timerbulatov, M. V. Timerbulatov, D. R. Akhmerov, V. M. Timerbulatov & A. R. Gafarova. (2022) Pseudomembranous colitis in patients with COVID-19 (review). Koloproktologia 21:4, pages 111-119.
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Tsu Jung Yang, Achint A Patel, Jassimran Singh, Vinay Jahagirdar, Dhanshree Solanki, Bharati Nikhare, Nishi Harwani, Ruchir Goswami, Hiteshkumar Devani, Prakash Maiyani, Dharmeshkumar V Moradiya, Maheshkumar Desai & Salman Muddassir. (2022) Increasing Trends of Clostridium difficile Infection in Hospitalized Young Patients: A Study of the National Inpatient Sample From 2007 to 2017. Cureus.
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Vanessa Lang, Katrin Gunka, Jan Rudolf Ortlepp, Ortrud Zimmermann & Uwe Groß. (2022) Risk Factors of Patients With Diarrhea for Having Clostridioides (Clostridium) difficile Infection. Frontiers in Microbiology 13.
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Julie D. Boatman, Michael P. Stevens & John Daniel Markley. 2022. Infection Prevention. Infection Prevention 47 71 .
Kathleen E. Orrell & Roman A. Melnyk. (2021) Large Clostridial Toxins: Mechanisms and Roles in Disease. Microbiology and Molecular Biology Reviews 85:3.
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Adriana Calderaro, Mirko Buttrini, Monica Martinelli, Benedetta Farina, Tiziano Moro, Sara Montecchini, Maria Cristina Arcangeletti, Carlo Chezzi & Flora De Conto. (2021) Rapid Classification of Clostridioides difficile Strains Using MALDI-TOF MS Peak-Based Assay in Comparison with PCR-Ribotyping. Microorganisms 9:3, pages 661.
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Pandhem Samarasimha R, Michael David & Singh Manoj Y. (2021) Long term outcomes of Hospital-Identified Clostridium Difficile Infection (HICDI): A retrospective cohort analysis of adult patients in a teaching hospital. Global Journal of Medical and Clinical Case Reports, pages 008-015.
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Nader S. Abutaleb & Mohamed N. Seleem. (2020) Repurposing the Antiamoebic Drug Diiodohydroxyquinoline for Treatment of Clostridioides difficile Infections. Antimicrobial Agents and Chemotherapy 64:6.
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Jennifer A. Pereira, Allison McGeer, Antigona Tomovici, Alex Selmani & Ayman Chit. (2020) Incidence and economic burden of Clostridioides difficile infection in Ontario: a retrospective population-based study . CMAJ Open 8:1, pages E16-E25.
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Adenrele Oludiran, David S. Courson, Malia D. Stuart, Anwar R. Radwan, John C. Poutsma, Myriam L. Cotten & Erin B. Purcell. (2019) How Oxygen Availability Affects the Antimicrobial Efficacy of Host Defense Peptides: Lessons Learned from Studying the Copper-Binding Peptides Piscidins 1 and 3. International Journal of Molecular Sciences 20:21, pages 5289.
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Tache Traian, Chirică Răzvan, Radu Marius-Daniel & Rugină Sorin. (2019) Epidemiological Characterization of Clostridium Difficile Infections in a Rural Community Setting. Internal Medicine 16:4, pages 27-32.
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S. Mileto, A. Das & D. Lyras. (2019) Enterotoxic Clostridia: Clostridioides difficile Infections . Microbiology Spectrum 7:3.
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Sabina Horvat & Maja Rupnik. (2018) Interactions Between Clostridioides difficile and Fecal Microbiota in in Vitro Batch Model: Growth, Sporulation, and Microbiota Changes. Frontiers in Microbiology 9.
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Sandra Wydau-Dematteis, Imane El Meouche, Pascal Courtin, Audrey Hamiot, René Lai-Kuen, Bruno Saubaméa, François Fenaille, Marie-José Butel, Jean-Louis Pons, Bruno Dupuy, Marie-Pierre Chapot-Chartier & Johann Peltier. (2018) Cwp19 Is a Novel Lytic Transglycosylase Involved in Stationary-Phase Autolysis Resulting in Toxin Release in Clostridium difficile . mBio 9:3.
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Rajani Thanissery, Daina Zeng, Raul G. Doyle & Casey M. Theriot. (2018) A Small Molecule-Screening Pipeline to Evaluate the Therapeutic Potential of 2-Aminoimidazole Molecules Against Clostridium difficile. Frontiers in Microbiology 9.
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Robert W. McKee, Naira Aleksanyan, Elizabeth M. Garrett & Rita Tamayo. (2018) Type IV Pili Promote Clostridium difficile Adherence and Persistence in a Mouse Model of Infection. Infection and Immunity 86:5.
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Feng Liao, Wenge Li, Wenpeng Gu, Wenzhu Zhang, Xiaoshu Liu, Xiaoqing Fu, Wen Xu, Yuan Wu & Jinxing Lu. (2018) A retrospective study of community-acquired Clostridium difficile infection in southwest China. Scientific Reports 8:1.
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Jeanne Couturier, Kerrie Davies, Cécile Gateau & Frédéric Barbut. 2018. Updates on Clostridium difficile in Europe. Updates on Clostridium difficile in Europe 45 58 .
John Daniel Markley & Michael P. Stevens. 2018. Infection Prevention. Infection Prevention 35 53 .
Marina Muñoz, Milena Camargo, Dora Inés Ríos-Chaparro, Paula Gómez, Manuel Alfonso Patarroyo & Juan David Ramírez. (2017) Community-acquired infection with hypervirulent Clostridium difficile isolates that carry different toxin and antibiotic resistance loci: a case report. Gut Pathogens 9:1.
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Melina Kachrimanidou, Olga Tsachouridou, Ioannis A. Ziogas, Eirini Christaki, Efthymia Protonotariou, Symeon Metallidis, Lemonia Skoura & Ed Kuijper. (2017) Clostridium difficile infections in a university hospital in Greece are mainly associated with PCR ribotypes 017 and 126. Journal of Medical Microbiology 66:12, pages 1774-1781.
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Kimberley Kavanagh, Jiafeng Pan, Charis Marwick, Peter Davey, Camilla Wiuff, Scott Bryson, Chris Robertson & Marion Bennie. (2016) Cumulative and temporal associations between antimicrobial prescribing and community-associated Clostridium difficile infection: population-based case–control study using administrative data . Journal of Antimicrobial Chemotherapy, pages dkw528.
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Stella Antonara & Amy L. Leber. (2016) Diagnosis of Clostridium difficile Infections in Children. Journal of Clinical Microbiology 54:6, pages 1425-1433.
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Tae-Geun Gweon, Jinsu Kim, Chul-Hyun Lim, Jae Myung Park, Dong-Gun Lee, In Seok Lee, Young-Seok Cho, Sang Woo Kim & Myung-Gyu Choi. (2016) Fecal Microbiota Transplantation Using Upper Gastrointestinal Tract for the Treatment of Refractory or Severe Complicated Clostridium difficile Infection in Elderly Patients in Poor Medical Condition: The First Study in an Asian Country . Gastroenterology Research and Practice 2016, pages 1-6.
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Sherin Justin & Beena Antony. (2015) POLYMERASE CHAIN REACTION FOR THE DETECTION OF TOXIN A ( TCD A ) AND TOXIN B ( TCD B ) GENES OF CLOSTRIDIUM DIFFICILE ISOLATED FROM DIARRHOEAL CASES AND ANALYSIS OF THE CLINICAL SPECTRUM. Journal of Evolution of Medical and Dental Sciences 4:29, pages 4938-4947.
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