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Perspectives

Antibiotic therapy and Clostridium difficile infection – primum non nocere – first do no harm

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Pages 333-337 | Published online: 15 Sep 2015

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John F Kokai-Kun, Chenxiong Le, Kenneth Trout, Julia L Cope, Nadim J Ajami, Andrew J Degar & Sheila Connelly. (2020) Ribaxamase, an Orally Administered β-Lactamase, Diminishes Changes to Acquired Antimicrobial Resistance of the Gut Resistome in Patients Treated with Ceftriaxone. Infection and Drug Resistance 13, pages 2521-2535.
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Hamideh Raeisi, Maryam Noori, Masoumeh Azimirad, Seyed Reza Mohebbi, Hamid Asadzadeh Aghdaei, Abbas Yadegar & Mohammad Reza Zali. (2023) Emerging applications of phage therapy and fecal virome transplantation for treatment of Clostridioides difficile infection: challenges and perspectives. Gut Pathogens 15:1.
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Nasia Safdar, Vishala Parmasad, Roger Brown, Pascale Carayon, Alexander Lepak, John C O'Horo & Lucas Schulz. (2021) Decreasing ICU-associated Clostridioides difficile infection through fluoroquinolone restriction, the FIRST trial: a study protocol . BMJ Open 11:6, pages e046480.
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Zakir Khan, Naveed Ahmed, Asim. ur. Rehman, Faiz Ullah Khan & Yusuf Karataş. (2019) Utilization Pattern of Antibiotics and Patient Care Indicators in the Teaching Hospitals, Islamabad, Pakistan. SN Comprehensive Clinical Medicine 1:10, pages 812-816.
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Sheila Connelly, Brian Fanelli, Nur A. Hasan, Rita R. Colwell & Michael Kaleko. (2019) Oral Metallo-Beta-Lactamase Protects the Gut Microbiome From Carbapenem-Mediated Damage and Reduces Propagation of Antibiotic Resistance in Pigs. Frontiers in Microbiology 10.
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Alessia Pascale, Nicoletta Marchesi, Cristina Marelli, Adriana Coppola, Livio Luzi, Stefano Govoni, Andrea Giustina & Carmine Gazzaruso. (2018) Microbiota and metabolic diseases. Endocrine 61:3, pages 357-371.
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Masoud Mardani. (2017) Prescription and Long- Term Use of Antibiotics in Hospitals. Archives of Clinical Infectious Diseases 12:3.
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John F. Kokai-Kun, Tracey Roberts, Olivia Coughlin, Eric Sicard, Marianne Rufiange, Richard Fedorak, Christian Carter, Marijke H. Adams, James Longstreth, Heidi Whalen & Joseph Sliman. (2017) The Oral β-Lactamase SYN-004 (Ribaxamase) Degrades Ceftriaxone Excreted into the Intestine in Phase 2a Clinical Studies. Antimicrobial Agents and Chemotherapy 61:3.
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