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Review

Pelargonium sidoides extract EPs 7630: a review of its clinical efficacy and safety for treating acute respiratory tract infections in children

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Pages 91-98 | Published online: 08 Mar 2018

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Won-Young Kim, Myung Jae Park, Chin Kook Rhee, Sang Yeub Lee, Do Jin Kim, Dong Gyu Kim, Chang-Min Choi, Deog Kyeom Kim, Yee Hyung Kim, Ho Joo Yoon & Jae Yeol Kim. (2020) HL301 versus Umckamin in the treatment of acute bronchitis: a phase III, randomized, controlled, double-blind, multicenter study. Current Medical Research and Opinion 36:3, pages 503-508.
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Nour Mammari, Quentin Albert, Marc Devocelle, Maša Kenda, Nina Kočevar Glavač, Marija Sollner Dolenc, Laura Mercolini, Jaroslav Tóth, Nagy Milan, Szilvia Czigle & Mihayl Varbanov. (2023) Natural Products for the Prevention and Treatment of Common Cold and Viral Respiratory Infections. Pharmaceuticals 16:5, pages 662.
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Zeynab Yousefian, Yousef Hamidoghli, Pooran Golkar & Mohammad Hossein Mirjalili. (2023) Growth patterns and biological activities of Pelargonium sidoides DC. hairy root cultures: A commercially-feasible industrial scale-up to improve yields. Industrial Crops and Products 194, pages 116272.
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Wolfgang Kamin, Ulrich Behre, Klaus Helm, Birgit Reling, Petra Funk & Fathi Abdul Malek. (2023) Safety of Pelargonium extract EPs 7630 in young children with acute bronchitis. Frontiers in Pediatrics 11.
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Giorgio CIPRANDI & Maria A. TOSCA. (2023) Non-pharmacological remedies for the common cold. Minerva Pediatrics 75:1.
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Alvaro Viljoen, Weiyang Chen, Nduvho Mulaudzi & Thomas Brendler. 2023. The South African Herbal Pharmacopoeia. The South African Herbal Pharmacopoeia 407 446 .
Fatma M. Abdel Bar, Manal A. Alossaimi, Engy Elekhnawy, May Abdullah Abulrahman Alzeer, Amal Abo Kamer, Ehssan Moglad & Mai H. ElNaggar. (2022) Anti-Quorum Sensing and Anti-Biofilm Activity of Pelargonium × hortorum Root Extract against Pseudomonas aeruginosa: Combinatorial Effect of Catechin and Gallic Acid. Molecules 27:22, pages 7841.
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Manal A. Alossaimi, May A. Alzeer, Fatma M. Abdel Bar & Mai H. ElNaggar. (2022) Pelargonium sidoides Root Extract: Simultaneous HPLC Separation, Determination, and Validation of Selected Biomolecules and Evaluation of SARS-CoV-2 Inhibitory Activity. Pharmaceuticals 15:10, pages 1184.
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Peter Kardos, Walter Lehmacher, Andrea Zimmermann, Juliette Brandes-Schramm, Petra Funk, Heinrich Matthys & Wolfgang Kamin. (2022) Effects of <em>Pelargonium sidoides</em> extract EPs 7630 on acute cough and quality of life – a meta-analysis of randomized, placebo-controlled trials. Multidisciplinary Respiratory Medicine 17.
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Can Celiloğlu, Ümit Çelik & Fatma Levent. 2022. Pediatric ENT Infections. Pediatric ENT Infections 1053 1061 .
Anthi Panara, Reza Aalizadeh & Nikolaos S. Thomaidis. (2021) Chemical characterisation of Pelargonium sidoides root based on LC‐QToF‐MS non‐target screening strategies . Phytochemical Analysis 33:1, pages 40-56.
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O. V. Borisova, N. M. Bochkareva, N. S. Polezhaeva, A. A. Frank & O. N. Yashkina. (2021) Application of a herbal preparation in the therapy of acute tonzillopharyngitis in children. Meditsinskiy sovet = Medical Council:17, pages 128-135.
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Georg Seifert, Petra Funk, Thorsten Reineke & Walter Lehmacher. (2021) Influence of EPs 7630 on Antipyretic Comedication and Recovery from Acute Tonsillopharyngitis in Children: A Meta-analysis of Randomized, Placebo-Controlled, Clinical Trials. Journal of Pediatric Infectious Diseases 16:03, pages 122-128.
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Tilman Keck, Andreas Strobl, Andreas Weinhaeusel, Petra Funk & Martin Michaelis. (2021) Pelargonium Extract EPs 7630 in the Treatment of Human Corona Virus-Associated Acute Respiratory Tract Infections – A Secondary Subgroup-Analysis of an Open-Label, Uncontrolled Clinical Trial. Frontiers in Pharmacology 12.
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Zeynab Yousefian, Pooran Golkar & Mohammad Hossein Mirjalili. (2020) Production Enhancement of Medicinally Active Coumarin and Phenolic Compounds in Hairy Root Cultures of Pelargonium sidoides: The Effect of Elicitation and Sucrose. Journal of Plant Growth Regulation 40:2, pages 628-641.
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Seda S. Grigoryan & Tatiana I. Garashchenko. (2021) Antiviral plant preparation as a topical treatment for respiratory viral infections in adults and children. Meditsinskiy sovet = Medical Council:1, pages 270-275.
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Oleksandr Bryda & Natalia Stadnytska. (2021) Antioxidant Activity of a Multicomponent Remedy Based on Extracts of Purifying Pelargonium Root, Oregano, and IVY. Journal Of Biochemical Technology 12:3, pages 53-58.
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Christin Walther, Kristin Döring & Michaela Schmidtke. (2020) Comparative in vitro analysis of inhibition of rhinovirus and influenza virus replication by mucoactive secretolytic agents and plant extracts. BMC Complementary Medicine and Therapies 20:1.
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Arif Jamal Siddiqui, Corina Danciu, Syed Amir Ashraf, Afrasim Moin, Ritu Singh, Mousa Alreshidi, Mitesh Patel, Sadaf Jahan, Sanjeev Kumar, Mulfi I. M. Alkhinjar, Riadh Badraoui, Mejdi Snoussi & Mohd Adnan. (2020) Plants-Derived Biomolecules as Potent Antiviral Phytomedicines: New Insights on Ethnobotanical Evidences against Coronaviruses. Plants 9:9, pages 1244.
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Rainer Stange & Bernhard Uehleke. (2020) Covid-19: Überlegungen zu Voraussetzungen von phytotherapeutischen Empfehlungen. Zeitschrift für Phytotherapie 41:04, pages 160-164.
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Justyna Baraniak & Małgorzata Kania-Dobrowolska. (2020) Pelargonium root ( Pelargonium sidoides DC) extract in paediatric patients - food supplement or medicine? . Herba Polonica 66:2, pages 28-33.
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Bharat Singh & Ram Avtar Sharma. 2020. Secondary Metabolites of Medicinal Plants. Secondary Metabolites of Medicinal Plants 810 821 .
John Nowicki & Michael T. Murray. 2020. Textbook of Natural Medicine. Textbook of Natural Medicine 1196 1201.e1 .
Andreas Schapowal, Gustav Dobos, Holger Cramer, Kian Chung Ong, Martin Adler, Andrea Zimmermann, Juliette Brandes-Schramm & Walter Lehmacher. (2019) Treatment of signs and symptoms of the common cold using EPs 7630 - results of a meta-analysis. Heliyon 5:11, pages e02904.
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A. Längler, T. J. Zuzak, O. Fricke & G. Seifert. (2019) Pflanzliche Arzneimittel in der PädiatrieHerbal medicines in pediatrics. Monatsschrift Kinderheilkunde 167:9, pages 768-777.
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Shakier Samie, Kim M. Trollope, Lydia-Marié Joubert, Nokwanda P. Makunga & Heinrich Volschenk. (2019) The antifungal and Cryptococcus neoformans virulence attenuating activity of Pelargonium sidoides extracts. Journal of Ethnopharmacology 235, pages 122-132.
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Michael Roth, Lei Fang, Daiana Stolz & Michael Tamm. (2019) Pelargonium sidoides radix extract EPs 7630 reduces rhinovirus infection through modulation of viral binding proteins on human bronchial epithelial cells. PLOS ONE 14:2, pages e0210702.
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Simone Reisdorf. (2019) Welche Phytos gegen Husten?. CME 16:1-2, pages 24-24.
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Tatjana Kundaković-Vasović & Jelena Radović. (2019) Herbal medicinal products in the treatment of cough associated with colds. Arhiv za farmaciju 69:4, pages 270-285.
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