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Review

Pharmacokinetics and pharmacodynamics of insulin analogs in special populations with type 2 diabetes mellitus

Pages 827-835 | Published online: 12 Dec 2011

Keep up to date with the latest research on this topic with citation updates for this article.

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Charline Bottinelli, Nathalie Cartiser, Fabien Bévalot, Laurent Fanton & Jérôme Guitton. (2020) Is insulin intoxication still the perfect crime? Analysis and interpretation of postmortem insulin: review and perspectives in forensic toxicology. Critical Reviews in Toxicology 50:4, pages 324-347.
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Oppel BW Greeff, Jacob John van Tonder, Kershlin Naidu, Alicia McMaster, Alet van Tonder & Rashem Mothilal. (2018) A practical guide to the interpretation of PK/PD profiles of longer-acting analogue insulins. Part one: The principles of glucose clamp studies. Journal of Endocrinology, Metabolism and Diabetes of South Africa 23:1, pages 17-21.
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Ronit Koren, Yoel Toledano & Moshe Hod. (2015) The use of insulin detemir during pregnancy: a safety evaluation. Expert Opinion on Drug Safety 14:4, pages 593-599.
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Articles from other publishers (45)

Jean C. Lu, Petrova Lee, Francesco Ierino, Richard J. MacIsaac, Elif Ekinci & David O’Neal. (2023) Challenges of Glycemic Control in People With Diabetes and Advanced Kidney Disease and the Potential of Automated Insulin Delivery. Journal of Diabetes Science and Technology, pages 193229682311740.
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Tsvetelina H. Baryakova, Brett H. Pogostin, Robert Langer & Kevin J. McHugh. (2023) Overcoming barriers to patient adherence: the case for developing innovative drug delivery systems. Nature Reviews Drug Discovery 22:5, pages 387-409.
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Shima Sheybani, Mahdi Kahrom, Raheleh Ganjali, Seyedeh Mahsa Kalati, Nahid Zirak & Vahideh Ghorani. (2023) Effects of glargine on hyperglycemia in patients with diabetes mellitus type II undergoing off-pump coronary artery bypass graft: A randomized, controlled, double-blind clinical trial. Journal of Cardiovascular and Thoracic Research 15:1, pages 44-50.
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Leona Plum-Mörschel, Lizette Ravn Andersen, Solvejg Hansen, Ulrike Hövelmann, Patricia Krawietz, Niels Rode Kristensen, Lars Lang Lehrskov & Hanne Haahr. (2023) Pharmacokinetic and Pharmacodynamic Characteristics of Insulin Icodec After Subcutaneous Administration in the Thigh, Abdomen or Upper Arm in Individuals with Type 2 Diabetes Mellitus. Clinical Drug Investigation 43:2, pages 119-127.
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Sujeet Kumar Raj, M. Ravindra Babu, Sukriti Vishwas, M.V.N.L. Chaitanya, Vancha Harish, Gaurav Gupta, Dinesh Kumar Chellappan, Kamal Dua & Sachin Kumar Singh. (2022) An overview of recent advances in insulin delivery and wearable technology for effective management of diabetes. Journal of Drug Delivery Science and Technology 75, pages 103728.
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E. S. Maloletkina, O. Y. Gurova, I. V. Glinkina, M. V. Amosova, Zh. Zh. Shyman, I. A. Khaykina, M. F. Kalashnikova & V. V. Fadeev. (2022) Comparison efficacy of different regimens of insulin therapy in patients with type 2 diabetes and morbid obesity. Meditsinskiy sovet = Medical Council:10, pages 62-74.
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Sylwia Strozyk, Anita Rogowicz-Frontczak, Stanislaw Pilacinski, Joanna LeThanh-Blicharz, Anna Koperska & Dorota Zozulinska-Ziolkiewicz. (2022) Influence of resistant starch resulting from the cooling of rice on postprandial glycemia in type 1 diabetes. Nutrition & Diabetes 12:1.
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David León‐Jiménez, José Pablo Miramontes‐González, Laura Márquez‐López, Francisco Astudillo‐Martín, Luis M. Beltrán‐Romero, Fernando Moreno‐Obregón & Javier Escalada‐San Martín. (2021) Basal insulin analogues in people with diabetes and chronic kidney disease. Diabetic Medicine 39:2.
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Rajeev Chawla, KalyanKumar Gangopadhyay, TejalBipin Lathia, Hitesh Punyani, Alok Kanungo, AbhayKumar Sahoo & KrishnaG Seshadri. (2022) Management of hyperglycemia in critical care. Journal of Diabetology 13:1, pages 33.
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Swati Arya, Adam J. Gourley, J. Carlos Penedo, Claudia A. Blindauer & Alan J. Stewart. (2021) Fatty acids may influence insulin dynamics through modulation of albumin‐Zn 2+ interactions . BioEssays 43:12, pages 2100172.
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Marco Infante, David A. Baidal, Michael R. Rickels, Andrea Fabbri, Jay S. Skyler, Rodolfo Alejandro & Camillo Ricordi. (2021) Dual‐hormone artificial pancreas for management of type 1 diabetes: Recent progress and future directions. Artificial Organs 45:9, pages 968-986.
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Anja Kristl, Aleš Podgornik & Matevž Pompe. (2021) Simultaneous separation of insulin and six therapeutic analogues on a mixed mode column: HPLC-UV method development and application. Journal of Chromatography B 1171, pages 122557.
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Andrew J. McLachlan & Jeffry Adiwidjaja. 2020. Biologics, Biosimilars, and Biobetters. Biologics, Biosimilars, and Biobetters 125 145 .
Hanne Haahr & Tim Heise. (2020) Fast-acting insulin aspart: a review of its pharmacokinetic and pharmacodynamic properties and the clinical consequences. Diabetes mellitus 23:2, pages 140-160.
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Irl B Hirsch & Boris Draznin. (2020) Transition of Patients to and from Insulin Degludec: A Clinical Challenge. The Journal of Clinical Endocrinology & Metabolism 105:6, pages e2294-e2298.
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Mariana P. Figueiredo, Géraldine Layrac, Anne Hébraud, Lionel Limousy, Jocelyne Brendle, Guy Schlatter & Vera R.L. Constantino. (2020) Design of 3D multi-layered electrospun membranes embedding iron-based layered double hydroxide for drug storage and control of sustained release. European Polymer Journal 131, pages 109675.
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Hanne Haahr & Tim Heise. (2019) Fast-Acting Insulin Aspart: A Review of its Pharmacokinetic and Pharmacodynamic Properties and the Clinical Consequences. Clinical Pharmacokinetics 59:2, pages 155-172.
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Greg Fulcher, Roopa Mehta, Edmond G. Fita, Magnus Ekelund & Stephen C. Bain. (2018) Efficacy and Safety of IDegAsp Versus BIAsp 30, Both Twice Daily, in Elderly Patients with Type 2 Diabetes: Post Hoc Analysis of Two Phase 3 Randomized Controlled BOOST Trials. Diabetes Therapy 10:1, pages 107-118.
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Thaiesha A. Wright, Richard C. Page & Dominik Konkolewicz. (2019) Polymer conjugation of proteins as a synthetic post-translational modification to impact their stability and activity. Polymer Chemistry 10:4, pages 434-454.
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Linda A. Morrow & Andrew J. Krentz. 2019. Translational Research Methods in Diabetes, Obesity, and Nonalcoholic Fatty Liver Disease. Translational Research Methods in Diabetes, Obesity, and Nonalcoholic Fatty Liver Disease 517 538 .
H. Lewis, R. Egerman, A. Kazory, M. Sattari & С. О. Шурпяк. (2018) Diabetes and Pregnancy: Risks and Opportunities. Family medicine:5, pages 53-59.
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Stefan Bilz, Miriam Flückiger, Fabian Meienberg, Claudine Falconnier, Ulrich Keller & Jardena J. Puder. (2018) Comparison of the dose-response pharmacodynamic profiles of detemir and glargine in severely obese patients with type 2 diabetes: A single-blind, randomised cross-over trial. PLOS ONE 13:8, pages e0202007.
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Masanari Shiramoto, Tomoyuki Nishida, Ann Kathrine Hansen & Hanne Haahr. (2018) Fast-acting insulin aspart in Japanese patients with type 1 diabetes: Faster onset, higher early exposure and greater early glucose-lowering effect relative to insulin aspart. Journal of Diabetes Investigation 9:2, pages 303-310.
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Gwang-Bum Im & Suk Ho Bhang. (2018) Recent research trend in cell and drug delivery system for type 1 diabetes treatment. Journal of Pharmaceutical Investigation 48:2, pages 175-185.
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Mitchel Tate, David J. GrieveRebecca H. Ritchie. (2017) Are targeted therapies for diabetic cardiomyopathy on the horizon?. Clinical Science 131:10, pages 897-915.
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Hanne Haahr, Edmond G. Fita & Tim Heise. (2016) A Review of Insulin Degludec/Insulin Aspart: Pharmacokinetic and Pharmacodynamic Properties and Their Implications in Clinical Use. Clinical Pharmacokinetics 56:4, pages 339-354.
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Karen Beer. (2017) Antihyperglycemic Medications. Physician Assistant Clinics 2:1, pages 25-38.
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Harivardhan Reddy Lakkireddy, Matthias Urmann, Melissa Besenius, Ulrich Werner, Torsten Haack, Priscilla Brun, Jean Alié, Brigitte Illel, Laurent Hortala, Rachel Vogel & Didier Bazile. (2016) Oral delivery of diabetes peptides — Comparing standard formulations incorporating functional excipients and nanotechnologies in the translational context. Advanced Drug Delivery Reviews 106, pages 196-222.
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Hanne Haahr, Tomio Sasaki, Lars Bardtrum & Ippei Ikushima. (2016) Insulin degludec/insulin aspart in Japanese patients with type 1 diabetes mellitus: Distinct prandial and basal glucose‐lowering effects. Journal of Diabetes Investigation 7:4, pages 574-580.
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S. Gentile, G. Guarino, F. Strollo, M. Romano, S. Genovese, M. Masarone & A. Ceriello. (2016) Lispro insulin in people with non-alcoholic liver cirrhosis and type 2 diabetes mellitus. Diabetes Research and Clinical Practice 113, pages 179-186.
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Surjit Dixit. 2015. Developability of Biotherapeutics. Developability of Biotherapeutics 35 60 .
Renee Y. Meadows. (2015) Optimal Glycemic Control in Hospitalized Patients. Hospital Medicine Clinics 4:4, pages 471-488.
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Linda Tran, Angela Zielinski, Arpi H. Roach, Jennifer A. Jende, Ann Marie Householder, Emily E. Cole, Shuruq A. Atway, Melinda Amornyard, Mallory L. Accursi, Suzanna W. Shieh & Erin E. Thompson. (2015) Pharmacologic Treatment of Type 2 Diabetes. Annals of Pharmacotherapy 49:6, pages 700-714.
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S. Franzè, F. Cilurzo & P. Minghetti. (2015) Insulin Biosimilars: The Impact on Rapid-Acting Analogue-Based Therapy. BioDrugs 29:2, pages 113-121.
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Linda A. Morrow & Andrew J. Krentz. 2015. Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development. Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development 225 242 .
Yang Xu, Marita Prohn, Xiaoyan Cai, Michael Crutchlow, Sudha S Shankar, Kevin Bateman & Eric J Woolf. (2014) Direct comparison of radioimmunoassay and LC–MS/MS for PK assessment of insulin glargine in clinical development. Bioanalysis 6:24, pages 3311-3323.
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Hanne Haahr & Tim Heise. (2014) A Review of the Pharmacological Properties of Insulin Degludec and Their Clinical Relevance. Clinical Pharmacokinetics 53:9, pages 787-800.
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Leszek Nosek, Hans-Veit Coester, Carsten Roepstorff, Henrik F. Thomsen, Niels R. Kristensen, Hanne Haahr & Tim Heise. (2014) Glucose-Lowering Effect of Insulin Degludec is Independent of Subcutaneous Injection Region. Clinical Drug Investigation 34:9, pages 673-679.
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Hanne M. Kinnunen & Randall J. Mrsny. (2014) Improving the outcomes of biopharmaceutical delivery via the subcutaneous route by understanding the chemical, physical and physiological properties of the subcutaneous injection site. Journal of Controlled Release 182, pages 22-32.
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Marcus Hompesch, Linda Morrow, Elaine Watkins, Carsten Roepstorff, Henrik F. Thomsen & Hanne Haahr. (2014) Pharmacokinetic and Pharmacodynamic Responses of Insulin Degludec in African American, White, and Hispanic/Latino Patients With Type 2 Diabetes Mellitus. Clinical Therapeutics 36:4, pages 507-515.
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Naomi Achong, Emma L. Duncan, H. David McIntyre & Leonie Callaway. (2014) Peripartum Management of Glycemia in Women With Type 1 Diabetes. Diabetes Care 37:2, pages 364-371.
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Viera Kupčová, Gerhard Arold, Carsten Roepstorff, Malene Højbjerre, Søren Klim & Hanne Haahr. (2013) Insulin Degludec: Pharmacokinetic Properties in Subjects with Hepatic Impairment. Clinical Drug Investigation 34:2, pages 127-133.
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Ibrahim Aslan, Ertan Kucuksayan & Mutay Aslan. (2013) Effect of insulin analog initiation therapy on LDL/HDL subfraction profile and HDL associated enzymes in type 2 diabetic patients. Lipids in Health and Disease 12:1.
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Luis G. Jahn, Jorge J. Capurro & Brian L. Levy. (2013) Comparative Dose Accuracy of Durable and Patch Insulin Infusion Pumps. Journal of Diabetes Science and Technology 7:4, pages 1011-1020.
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Gillian M. Keating. (2012) Insulin Detemir. Drugs 72:17, pages 2255-2287.
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