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International Journal of General Medicine Volume 14, 2021 - Issue
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Clinical Trial Report

Colchicine in Recently Hospitalized Patients with COVID-19: A Randomized Controlled Trial (COL-COVID)

Domingo A Pascual-Figal1 Cardiology Department, Hospital Universitario Virgen de la Arrixaca, IMIB-Arrixaca, Universidad de Murcia, Murcia, Spain;2 Centro de Investigación Biomédica en Red Enfermedades Cardiovasculares, (CIBERCV), Madrid, Spain;3 Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, SpainCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-4993-9540View further author information
ORCID Icon,
Aychel E Roura-Piloto4 Infectious Diseases and Internal Medicine Department, Hospital Universitario Virgen de la Arrixaca, IMIB-Arrixaca, Universidad de Murcia, Murcia, SpainView further author information
,
Encarnación Moral-Escudero4 Infectious Diseases and Internal Medicine Department, Hospital Universitario Virgen de la Arrixaca, IMIB-Arrixaca, Universidad de Murcia, Murcia, SpainView further author information
,
Enrique Bernal5 Infectious Diseases and Internal Medicine Department, Hospital Universitario Reina Sofia, IMIB-Arrixaca, Universidad de Murcia, Murcia, SpainView further author information
,
Helena Albendín-Iglesias4 Infectious Diseases and Internal Medicine Department, Hospital Universitario Virgen de la Arrixaca, IMIB-Arrixaca, Universidad de Murcia, Murcia, SpainView further author information
,
M Teresa Pérez-Martínez1 Cardiology Department, Hospital Universitario Virgen de la Arrixaca, IMIB-Arrixaca, Universidad de Murcia, Murcia, SpainView further author information
,
Jose Antonio Noguera-Velasco6 Clinical Biochemistry Department, Hospital Universitario Virgen de la Arrixaca, IMIB-Arrixaca, Universidad de Murcia, Murcia, SpainView further author information
,
Iria Cebreiros-López6 Clinical Biochemistry Department, Hospital Universitario Virgen de la Arrixaca, IMIB-Arrixaca, Universidad de Murcia, Murcia, SpainView further author information
,
Álvaro Hernández-Vicente1 Cardiology Department, Hospital Universitario Virgen de la Arrixaca, IMIB-Arrixaca, Universidad de Murcia, Murcia, SpainView further author information
,
David Vázquez-Andrés1 Cardiology Department, Hospital Universitario Virgen de la Arrixaca, IMIB-Arrixaca, Universidad de Murcia, Murcia, SpainView further author information
,
Carmen Sánchez-Pérez2 Centro de Investigación Biomédica en Red Enfermedades Cardiovasculares, (CIBERCV), Madrid, SpainView further author information
,
Amjad Khan7 Department of Chemistry, University of Oxford, Oxford, UKView further author information
,
Fátima Sánchez-Cabo3 Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, SpainView further author information
,
Elisa García-Vázquez4 Infectious Diseases and Internal Medicine Department, Hospital Universitario Virgen de la Arrixaca, IMIB-Arrixaca, Universidad de Murcia, Murcia, SpainView further author information
& On behalf of the COL-COVID Investigators show all
Pages 5517-5526 | Published online: 11 Sep 2021

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Rania Gamal El Sayed, Amr Fouad Hafez, Adham Magdy Ahmed Mohammed Haggag & Mohamed A. Alhadidy. (2022) Effect of combined use of ivermectin and colchicine in COVID-19 patients. Egyptian Journal of Anaesthesia 38:1, pages 365-372.
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Shao-Huan Lan, Chi-Kuei Hsu, Chih-Cheng Lai, Shen-Peng Chang, Li-Chin Lu, Shun-Hsing Hung & Wei-Ting Lin. (2022) Effect of colchicine on the outcomes of patients with COVID-19: a systematic review and meta-analysis of randomised controlled trials. Annals of Medicine 54:1, pages 1956-1965.
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Ahmad Naoras Bitar & Syed Azhar Syed Sulaiman. (2022) The evidence from clinical trials on colchicine and corticosteroids’ effect on COVID-19: a systematic review and meta-analysis. Current Medical Research and Opinion 38:12, pages 2097-2108.
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Articles from other publishers (21)

Zhiyue Li, Xueqin Yan, Jiangchun Wei, Liuyang Pu, Guanbao Zhu, Yongkai Cao, Zhanyan Liu, Yaqian Liu, Yan Li, Limin Li, Xinping Li & Zhengzhi Wu. (2023) A novel colchicine-myricetin heterozygous molecule: design, synthesis, and effective evaluations on the pathological models of acute lung injury in vitro and in vivo. Frontiers in Pharmacology 14.
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David Sweet, Michael Freeman & David Zidar. (2023) Immunohematologic Biomarkers in COVID-19: Insights into Pathogenesis, Prognosis, and Prevention. Pathogens and Immunity 8:1.
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Raushanara Akter, Md. Rashidur Rahman, Zainab Syed Ahmed & Afrina Afrose. (2023) Plausibility of natural immunomodulators in the treatment of COVID-19–A comprehensive analysis and future recommendations. Heliyon 9:6, pages e17478.
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Elisa Souza Vaz, Sandra Valeria Vassiliades, Jeanine Giarolla, Michelle Carneiro Polli & Roberto Parise-Filho. (2023) Drug repositioning in the COVID-19 pandemic: fundamentals, synthetic routes, and overview of clinical studies. European Journal of Clinical Pharmacology 79:6, pages 723-751.
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Sandy Sharaf, Rasha Ashmawy, Eman Saleh, Mayada Salama, Yousra El-Maradny, Ali Zari, Shahinda Aly, Ahmed Tolba, Doaa Mahrous, Hanan Elsayed, Dalia Latif, Elrashdy Redwan & Ehab Kamal. (2023) Oxygen Saturation in Hospitalized COVID-19 Patients and Its Relation to Colchicine Treatment: A Retrospective Cohort Study with an Updated Systematic Review. Medicina 59:5, pages 934.
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María Sáenz‐Aldea, Ángel Salgado‐Barreira, Margarita Taracido Trunk, María Piñeiro‐Lamas, Maria T. Herdeiro, Manuel Portela‐Romero, Marc Saez & Adolfo Figueiras. (2023) Colchicine and risk of hospitalization due to COVID‐19: A population‐based study. Journal of Medical Virology 95:2.
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Maureen Yin, Laura Marrone, Christian G Peace & Luke A J O’Neill. (2023) NLRP3, the inflammasome and COVID-19 infection. QJM: An International Journal of Medicine.
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Lívia Pimenta Bonifácio, Eduardo Ramacciotti, Leandro Barile Agati, Fernando Crivelenti Vilar, Anna Christina Tojal da Silva, Paulo Louzada Júnior, Benedito Antônio Lopes da Fonseca, Hayala Cristina Cavenague de Souza, Caroline Candida Carvalho de Oliveira, Valéria Cristina Resende Aguiar, Carlos Augusto de Aguiar Quadros, Cesar Dusilek, Kengi Itinose, Ricardo Risson, Lucas Roberto Rivabem Ferreira, Renato Delascio Lopes, Esper Georges Kallas & Fernando Bellissimo-Rodrigues. (2023) Efficacy and safety of Ixekizumab vs. low-dose IL-2 vs. Colchicine vs. standard of care in the treatment of patients hospitalized with moderate-to-critical COVID-19: A pilot randomized clinical trial (STRUCK: Survival Trial Using Cytokine Inhibitors). Revista da Sociedade Brasileira de Medicina Tropical 56.
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Carlo Perricone, Mirko Scarsi, Antonio Brucato, Paola Pisano, Erika Pigatto, Cecilia Becattini, Antonella Cingolani, Francesco Tiso, Roberto Prota, Lina Rachele Tomasoni, Maurizio Cutolo, Marika Tardella, Davide Rozza, Carlo Zerbino, Massimo Andreoni, Venerino Poletti, Elena Bartoloni, Roberto Gerli, Giacomo Cafaro, Monia Mendeni, Enrico Colombo, Marta Del Medico, Paola Cabras, Mauro Giovanni Schiesaro, Laura Franco, Massimo Fantoni, Lara Friso, Valter Gallo, Franco Franceschini, Sabrina Paolino, Fausto Salaffi, Carlo Scirè, Anna Zanetti, Claudia Diana, Angelina Passaro, Rosario Foti, Francesco Saverio Serino, Maurizio Cassol, Giampaolo Bucaneve & Rosalba Elisabetta Rocchi. (2023) Treatment with COLchicine in hospitalized patients affected by COVID-19: The COLVID-19 trial. European Journal of Internal Medicine 107, pages 30-36.
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Mihir Halder, Rahul Bose & Sumita Jha. 2023. Medicinal Plants: Biodiversity, Biotechnology and Conservation. Medicinal Plants: Biodiversity, Biotechnology and Conservation 465 524 .
Nicola Potere, Marco Giuseppe Del Buono, Roberto Caricchio, Paul C. Cremer, Alessandra Vecchié, Ettore Porreca, Daniela Dalla Gasperina, Francesco Dentali, Antonio Abbate & Aldo Bonaventura. (2022) Interleukin-1 and the NLRP3 inflammasome in COVID-19: Pathogenetic and therapeutic implications. eBioMedicine 85, pages 104299.
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José Hernández-Rodríguez, Julio Durán-Sanclemente, Sergio Prieto-González, Olga Araújo, Teresa Hospital-Vidal, Georgina Casanovas, Víctor Sapena, José Luis Blanco, Alfonso López-Soto, Francisco J. Afonso, Jesús Aibar, Xavier Alemany, Luis Aparicio, Yolanda Asensio, Anna Aldea-Parés, Ana B. Azuaga, Giuseppe Barilaro, Nieves Benages, Katherine Cajiao, Júlia Calvo, Maria del Carme Cañueto, Aina Capdevila-Reniu, Irene Carbonell, Miriam Costafreda, Cecilia Cuzco, Anna de-Daniel-Bisbe, Gema Doménech, Mónica Doménech, Gerard Espinosa, Maria Feliu, Alberto Foncillas, Cristina Gabara, Gloria Gámez, Carlos García-Gutiérrez, Lucía García-Jarque, Andrea García-Ortega, Begoña Gómez, Verónica Gómez-Caverzaschi, Vanesa Gómez-Urbano, Tania Gonzalo, Ignacio Grafia, Neus Guasch, Mar Guillén, Ana M. Guió, Marta Illa, Marco Inzitari, Maria Joyera, Andrea Ladino, Irina S. Luzko-Scheid, Gema M. Lledó, Néstor López-Guerra, Daniel Marco, Guillem Masdeu, Ana Matas-García, Irene Macaya, Ferran Masanés, Miriam I. Mayor, José C. Milisenda, Montse Montero, Verónica Montes, Marc Montoya-Rodés, Núria Moragas, Alma Morancho, Pedro J. Moreno, José Naval, Josep Ortega, Anna Pahisa, Martina Pellicé, Sona Pilarcikova, Ester Pujol, Elisabet Rivero, Joan Ribot, Roberto Ríos-Garcés, Olga Rodríguez-Núñez, Omar M. Saavedra, Emilio Sacanella, Adelaido Salazar, Adriana San Miguel, Amparo Sánchez-Buitrago, Víctor Sánchez-Palacios, Ángeles Sanz, Ferran Seguí, Adrià Tomé-Pérez, Manuel Torres-Elorza, Montse Tuset, Helena Ventosa, Roser Ventura, Esther Viñas-Esmel & Carles Zamora. (2022) FRAGILE-COLCOVID19: A Clinical Trial Based on Early Administration of an Oral Combination of Colchicine and Prednisone in Elderly Patients with COVID-19 in Geriatric Facilities. Clinical Drug Investigation 42:11, pages 949-964.
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Heath White, Steve J McDonald, Bridget Barber, Joshua Davis, Lucy Burr, Priya Nair, Sutapa Mukherjee, Britta Tendal, Julian Elliott, Steven McGloughlin & Tari Turner. (2022) Care for adults with COVID ‐19: living guidelines from the National COVID ‐19 Clinical Evidence Taskforce . Medical Journal of Australia 217:7, pages 368-378.
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Adarsh Bhimraj, Rebecca L Morgan, Amy Hirsch Shumaker, Lindsey R Baden, Vincent Chi-Chung Cheng, Kathryn M Edwards, Jason C Gallagher, Rajesh T Gandhi, William J Muller, Mari M Nakamura, John C O’Horo, Robert W Shafer, Shmuel Shoham, M Hassan Murad, Reem A Mustafa, Shahnaz Sultan & Yngve Falck-Ytter. (2022) Infectious Diseases Society of America Guidelines on the Treatment and Management of Patients With Coronavirus Disease 2019 (COVID-19). Clinical Infectious Diseases.
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Heng Zhang, Qifang Lao, Jue Zhang & Jieqing Zhu. (2022) Coagulopathy in COVID-19 and anticoagulation clinical trials. Best Practice & Research Clinical Haematology 35:3, pages 101377.
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Francisco José Romeo, Leandro Barbagelata, Juan Guido Chiabrando, Juan Ignacio Damonte, Errol Moras, Jose S. Aguilar-Gallardo, Marta Lorente-Ros, Lorenzo Martin Lobo & Walter Masson. (2022) The Effect of Colchicine on Mortality, Mechanical Ventilation, and Length of Stay in Patients With COVID-19 Infection: An Updated Systematic Review and Meta-analysis of Randomized Clinical Trials. American Journal of Therapeutics 29:3, pages e344-e350.
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Ahmet DOĞAN, Taliha KARAKÖK & Yakup GEZER. (2022) Efficacy of colchicine treatment in COVID-19 patients: A case-control studyCOVID-19 hastalarında kolşisin tedavisinin etkinliği: Bir vaka-kontrol çalışması. Archives of Clinical and Experimental Medicine 7:1, pages 11-14.
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Dimitrios Patoulias, Christodoulos Papadopoulos, Asterios Karagiannis & Michael Doumas. (2022) Colchicine for the prevention of COVID-19 “hard” outcomes: All that glitters is not gold. European Journal of Internal Medicine 97, pages 108-109.
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Aldo Bonaventura, Alessandra Vecchié, Lorenzo Dagna, Flavio Tangianu, Antonio Abbate & Francesco Dentali. (2022) Colchicine for COVID-19: targeting NLRP3 inflammasome to blunt hyperinflammation. Inflammation Research 71:3, pages 293-307.
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Chia Siang Kow, Learn‐Han Lee, Dinesh Sangarran Ramachandram, Syed Shahzad Hasan, Long Chiau Ming & Hui Poh Goh. (2021) The effect of colchicine on mortality outcome and duration of hospital stay in patients with COVID‐19: A meta‐analysis of randomized trials. Immunity, Inflammation and Disease 10:2, pages 255-264.
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Noha A. Kamel, Nasser S. M. Ismail, Ibrahim S. Yahia & Khaled M. Aboshanab. (2021) Potential Role of Colchicine in Combating COVID-19 Cytokine Storm and Its Ability to Inhibit Protease Enzyme of SARS-CoV-2 as Conferred by Molecular Docking Analysis. Medicina 58:1, pages 20.
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