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International Journal of Nanomedicine Volume 12, 2017 - Issue
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Original Research

Silica nanoparticles induce liver fibrosis via TGF-β1/Smad3 pathway in ICR mice

Yang Yu1 School of Public Health, Capital Medical University, Beijing, People’s Republic of China;2 Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, People’s Republic of China
,
Junchao Duan1 School of Public Health, Capital Medical University, Beijing, People’s Republic of China;2 Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, People’s Republic of China
,
Yang Li1 School of Public Health, Capital Medical University, Beijing, People’s Republic of China;2 Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, People’s Republic of China
,
Yanbo Li1 School of Public Health, Capital Medical University, Beijing, People’s Republic of China;2 Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, People’s Republic of China
,
Li Jing1 School of Public Health, Capital Medical University, Beijing, People’s Republic of China;2 Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, People’s Republic of China
,
Man Yang1 School of Public Health, Capital Medical University, Beijing, People’s Republic of China;2 Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, People’s Republic of China
,
Ji Wang1 School of Public Health, Capital Medical University, Beijing, People’s Republic of China;2 Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, People’s Republic of China
&
Zhiwei Sun1 School of Public Health, Capital Medical University, Beijing, People’s Republic of China;2 Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, People’s Republic of ChinaCorrespondence[email protected]
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Pages 6045-6057 | Published online: 21 Aug 2017

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Qingqing Liang, Yuexiao Ma, Fenghong Wang, Mengqi Sun, Lisen Lin, Tianyu Li, Junchao Duan & Zhiwei Sun. (2023) Ferritinophagy was involved in long-term SiNPs exposure induced ferroptosis and liver fibrosis. Nanotoxicology 17:2, pages 157-175.
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Yang Yu, Tingting Zhu, Yang Li, Li Jing, Man Yang, Yanbo Li, Junchao Duan & Zhiwei Sun. (2019) Repeated intravenous administration of silica nanoparticles induces pulmonary inflammation and collagen accumulation via JAK2/STAT3 and TGF-β/Smad3 pathways in vivo. International Journal of Nanomedicine 14, pages 7237-7247.
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Junchao Duan, Shuang Liang, Lin Feng, Yang Yu & Zhiwei Sun. (2018) Silica nanoparticles trigger hepatic lipid-metabolism disorder in vivo and in vitro. International Journal of Nanomedicine 13, pages 7303-7318.
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