Advanced search
Publication Cover
International Journal of Nanomedicine Volume 6, 2011 - Issue
Submit an article Journal homepage
272
Views
72
CrossRef citations to date
0
Altmetric
Original Research

A 3D model of ovarian cancer cell lines on peptide nanofiber scaffold to explore the cell–scaffold interaction and chemotherapeutic resistance of anticancer drugs

Zehong Yang1 Nanomedicine Laboratory, West China Hospital and Institute for Nanobiomedical Technology and Membrane Biology, Sichuan University, Chengdu, People’s Republic of China
&
Xiaojun Zhao1 Nanomedicine Laboratory, West China Hospital and Institute for Nanobiomedical Technology and Membrane Biology, Sichuan University, Chengdu, People’s Republic of China;2 Center for Biomedical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USACorrespondence[email protected]
Pages 303-310 | Published online: 02 Feb 2011

Citations (72)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Rongrong Wang, Zhaoyue Wang, Yayuan Guo, Hongmin Li & Zhuoyue Chen. (2019) Design of a RADA16-based self-assembling peptide nanofiber scaffold for biomedical applications. Journal of Biomaterials Science, Polymer Edition 30:9, pages 713-736.
Read now
Yvonne Peck & Dong-An Wang. (2013) Three-dimensionally engineered biomimetic tissue models for in vitro drug evaluation: delivery, efficacy and toxicity. Expert Opinion on Drug Delivery 10:3, pages 369-383.
Read now

Articles from other publishers (70)

Jana Sievers, Vaibhav Mahajan, Petra B. Welzel, Carsten Werner & Anna Taubenberger. (2023) Precision Hydrogels for the Study of Cancer Cell Mechanobiology. Advanced Healthcare Materials 12:14.
Crossref
Vijay Sagar Madamsetty, Maryam Vazifehdoost, Samira Hossaini Alhashemi, Hesam Davoudi, Ali Zarrabi, Ali Dehshahri, Hojjat Samareh Fekri, Reza Mohammadinejad & Vijay Kumar Thakur. (2023) Next-Generation Hydrogels as Biomaterials for Biomedical Applications: Exploring the Role of Curcumin. ACS Omega 8:10, pages 8960-8976.
Crossref
Joe T. Sharick, Angelina J. Atieh, Keith J. Gooch & Jennifer L. Leight. (2022) Click chemistry functionalization of self‐assembling peptide hydrogels . Journal of Biomedical Materials Research Part A 111:3, pages 389-403.
Crossref
Marcin Iwanicki, Tonja Pavlovic & Panteha Behboodi. 2023. Engineering and Physical Approaches to Cancer. Engineering and Physical Approaches to Cancer 231 253 .
Zuzanna Bober, David Aebisher, Marcin Olek, Aleksandra Kawczyk-Krupka & Dorota Bartusik-Aebisher. (2022) Multiple Cell Cultures for MRI Analysis. International Journal of Molecular Sciences 23:17, pages 10109.
Crossref
Priyadarshi Chakraborty, Lihi Adler‐Abramovich & Ehud Gazit. 2022. Multifunctional Hydrogels for Biomedical Applications. Multifunctional Hydrogels for Biomedical Applications 127 147 .
Simona Braccini, Chiara Tacchini, Federica Chiellini & Dario Puppi. (2022) Polymeric Hydrogels for In Vitro 3D Ovarian Cancer Modeling. International Journal of Molecular Sciences 23:6, pages 3265.
Crossref
Priyanka Gupta, Aline Miller, Adedamola Olayanju, Thumuluru Kavitha Madhuri & Eirini Velliou. (2022) A Systematic Comparative Assessment of the Response of Ovarian Cancer Cells to the Chemotherapeutic Cisplatin in 3D Models of Various Structural and Biochemical Configurations—Does One Model Type Fit All?. Cancers 14:5, pages 1274.
Crossref
Christine Yee, Kristie-Ann Dickson, Mohammed N. Muntasir, Yue Ma & Deborah J. Marsh. (2022) Three-Dimensional Modelling of Ovarian Cancer: From Cell Lines to Organoids for Discovery and Personalized Medicine. Frontiers in Bioengineering and Biotechnology 10.
Crossref
Gülsün Bağcı, Celia Ximenes-Carballo, Soledad Perez-Amodio, Oscar Castaño, Elisabeth Engel & Barbara Blanco-Fernandez. 2022.
Irmak Ayvaz, Dilara Sunay, Ece Sariyar, Esra Erdal & Zeynep Firtina Karagonlar. (2021) Three-Dimensional Cell Culture Models of Hepatocellular Carcinoma — a Review. Journal of Gastrointestinal Cancer 52:4, pages 1294-1308.
Crossref
Ana Karen Mendoza-Martinez, Daniela Loessner, Alvaro Mata & Helena S. Azevedo. (2021) Modeling the Tumor Microenvironment of Ovarian Cancer: The Application of Self-Assembling Biomaterials. Cancers 13:22, pages 5745.
Crossref
Stephen J. Winter, Hunter A. Miller & Jill M. Steinbach-Rankins. (2021) Multicellular Ovarian Cancer Model for Evaluation of Nanovector Delivery in Ascites and Metastatic Environments. Pharmaceutics 13:11, pages 1891.
Crossref
Eric N. Horst, Michael E. Bregenzer, Pooja Mehta, Catherine S. Snyder, Taylor Repetto, Yang Yang-Hartwich & Geeta Mehta. (2021) Personalized models of heterogeneous 3D epithelial tumor microenvironments: Ovarian cancer as a model. Acta Biomaterialia 132, pages 401-420.
Crossref
Helen C. Clough, Marie O'Brien, Xinyi Zhu, Aline F. Miller, Alberto Saiani & Olga Tsigkou. (2021) Neutrally charged self-assembling peptide hydrogel recapitulates in vitro mechanisms of breast cancer progression. Materials Science and Engineering: C 127, pages 112200.
Crossref
David Angelats Lobo, Paola Ginestra, Elisabetta Ceretti, Teresa Puig Miquel & Joaquim Ciurana. (2021) Cancer Cell Direct Bioprinting: A Focused Review. Micromachines 12:7, pages 764.
Crossref
Jingwen Xu, Guangyan Qi, Weiqun Wang & Xiuzhi Susan Sun. (2021) Advances in 3D peptide hydrogel models in cancer research. npj Science of Food 5:1.
Crossref
Barbara Blanco‐Fernandez, Vítor M. Gaspar, Elisabeth Engel & João F. Mano. (2021) Proteinaceous Hydrogels for Bioengineering Advanced 3D Tumor Models. Advanced Science 8:4, pages 2003129.
Crossref
Remya Komeri, H. P. Syama, G. U. Preethi, B. S. Unnikrishnan, R. Shiji, M. G. Archana, Deepa Mohan, Anuj Tripathi & T. T. Sreelekha. 2021. Immobilization Strategies. Immobilization Strategies 165 193 .
Tanya Singh, Adam S. Neal, Neda A. Moatamed & Sanaz Memarzadeh. (2020) Exploring the Potential of Drug Response Assays for Precision Medicine in Ovarian Cancer. International Journal of Molecular Sciences 22:1, pages 305.
Crossref
Hong Song, Guo-hui Cai, Jian Liang, Di-shu Ao, Huan Wang & Ze-hong Yang. (2020) Three-dimensional culture and clinical drug responses of a highly metastatic human ovarian cancer HO-8910PM cells in nanofibrous microenvironments of three hydrogel biomaterials. Journal of Nanobiotechnology 18:1.
Crossref
Kai Li, Yuting Zhu, Qiang Zhang, Xiaoli Shi, Feng Liang & Dong Han. (2020) A Self-Healing Hierarchical Fiber Hydrogel That Mimics ECM Structure. Materials 13:22, pages 5277.
Crossref
Advika Kamatar, Gokhan Gunay & Handan Acar. (2020) Natural and Synthetic Biomaterials for Engineering Multicellular Tumor Spheroids. Polymers 12:11, pages 2506.
Crossref
Ushashi C. Dadwal, Alyssa R. Merkel, Jonathan M. Page, Kristin A. Kwakwa, Michael Kessler & Julie A. Rhoades. (2020) 3D Bone Morphology Alters Gene Expression, Motility, and Drug Responses in Bone Metastatic Tumor Cells. International Journal of Molecular Sciences 21:18, pages 6913.
Crossref
Zehong Yang, Hongyan Xu & Xiaojun Zhao. (2020) Designer Self‐Assembling Peptide Hydrogels to Engineer 3D Cell Microenvironments for Cell Constructs Formation and Precise Oncology Remodeling in Ovarian Cancer. Advanced Science 7:9, pages 1903718.
Crossref
Amir Zarebkohan, Roghayeh Sheervalilou, Roya Ghods, Subhas C. Kundu & Mazaher Gholipourmalekabadi. 2020. Biomaterials for 3D Tumor Modeling. Biomaterials for 3D Tumor Modeling 305 328 .
Adeeb Shehzad, Vijaya Ravinayagam, Hamad AlRumaih, Meneerah Aljafary, Dana Almohazey, Sarah Almofty, Noor A. Al-Rashid & Ebtesam A. Al-Suhaimi. (2019) Application of Three-dimensional (3D) Tumor Cell Culture Systems and Mechanism of Drug Resistance. Current Pharmaceutical Design 25:34, pages 3599-3607.
Crossref
M. H. Zoughaib, D. T. Luong, Z. Y. Siraeva, A. A. Yergeshov, T. I. Salikhova, S. V. Kuznetsova, R. G. Kiyamova & T. I. Abdullin. (2019) Tumor Cell Behavior in Porous Hydrogels: Effect of Application Technique and Doxorubicin Treatment. Bulletin of Experimental Biology and Medicine 167:4, pages 590-598.
Crossref
Sharjeel Abid, Tanveer Hussain, Zulfiqar Ali Raza & Ahsan Nazir. (2019) Current applications of electrospun polymeric nanofibers in cancer therapy. Materials Science and Engineering: C 97, pages 966-977.
Crossref
Honglin Luo, Yang Zhang, Deqiang Gan, Zhiwei Yang, Haiyong Ao, Quanchao Zhang, Fanglian Yao & Yizao Wan. (2019) Incorporation of hydroxyapatite into nanofibrous PLGA scaffold towards improved breast cancer cell behavior. Materials Chemistry and Physics 226, pages 177-183.
Crossref
Elisabeth Prince & Eugenia Kumacheva. (2019) Design and applications of man-made biomimetic fibrillar hydrogels. Nature Reviews Materials 4:2, pages 99-115.
Crossref
Jun Guo, Chunting Zhao, Ruyong Yao, Aihua Sui, Lingjie Sun, Xiaodan Liu, Shaoling Wu, Zhan Su, Tianlan Li, Shanshan Liu, Yan Gao, Jiaxiu Liu, Xianqi Feng, Wei Wang, Hongguo Zhao, Zhongguang Cui, Guanglun Li & Fanjun Meng. (2019) 3D culture enhances chemoresistance of ALL Jurkat cell line by increasing DDR1 expression. Experimental and Therapeutic Medicine.
Crossref
Karen M. Watters, Preety Bajwa & Hilary A. Kenny. (2018) Organotypic 3D Models of the Ovarian Cancer Tumor Microenvironment. Cancers 10:8, pages 265.
Crossref
Yunfeng Li & Eugenia Kumacheva. (2018) Hydrogel microenvironments for cancer spheroid growth and drug screening. Science Advances 4:4.
Crossref
Chya-Yan Liaw, Shen Ji & Murat Guvendiren. (2018) Engineering 3D Hydrogels for Personalized In Vitro Human Tissue Models. Advanced Healthcare Materials 7:4, pages 1701165.
Crossref
Sigrid A. Langhans. (2018) Three-Dimensional in Vitro Cell Culture Models in Drug Discovery and Drug Repositioning. Frontiers in Pharmacology 9.
Crossref
Gayatri C. Patel & Bindu K. Yadav. 2018. Organic Materials as Smart Nanocarriers for Drug Delivery. Organic Materials as Smart Nanocarriers for Drug Delivery 147 175 .
Amani I. Moraya, Jennifer L. Ali, Pranati Samadder, Lisa Liang, Ludivine Coudière Morrison, Tamra E. Werbowetski-Ogilvie, Makanjuola Ogunsina, Frank Schweizer, Gilbert Arthur & Mark W. Nachtigal. (2017) Novel glycolipid agents for killing cisplatin-resistant human epithelial ovarian cancer cells. Journal of Experimental & Clinical Cancer Research 36:1.
Crossref
Donglai Lv, Zongtao Hu, Lin Lu, Husheng Lu & Xiuli Xu. (2017) Three‑dimensional cell culture: A powerful tool in tumor research and drug discovery (Review). Oncology Letters.
Crossref
Samantha E. Holt, E. Sally Ward, Raimund J. Ober & Daniel L. Alge. (2017) Shooting for the moon: using tissue-mimetic hydrogels to gain new insight on cancer biology and screen therapeutics. MRS Communications 7:3, pages 427-441.
Crossref
Nitish Peela, Danh Truong, Harpinder Saini, Hunghao Chu, Samaneh Mashaghi, Stephanie L. Ham, Sunil Singh, Hossein Tavana, Bobak Mosadegh & Mehdi Nikkhah. (2017) Advanced biomaterials and microengineering technologies to recapitulate the stepwise process of cancer metastasis. Biomaterials 133, pages 176-207.
Crossref
Xiao-Qiu Dou & Chuan-Liang Feng. (2017) Amino Acids and Peptide-Based Supramolecular Hydrogels for Three-Dimensional Cell Culture. Advanced Materials 29:16, pages 1604062.
Crossref
Aleksander Salomon-Perzyński, Magdalena Salomon-Perzyńska, Bogdan Michalski & Violetta Skrzypulec-Plinta. (2017) High-grade serous ovarian cancer: the clone wars. Archives of Gynecology and Obstetrics 295:3, pages 569-576.
Crossref
Eric Y. Du, Adam D. Martin, Celine Heu & Pall Thordarson. (2017) The Use of Hydrogels as Biomimetic Materials for 3D Cell Cultures. Australian Journal of Chemistry 70:1, pages 1.
Crossref
Neha Arya & Aurelien Forget. 2017. Advances in Biomaterials for Biomedical Applications. Advances in Biomaterials for Biomedical Applications 301 361 .
Shantanu PradhanIman HassaniJacob M. ClaryElizabeth A. Lipke. (2016) Polymeric Biomaterials for In Vitro Cancer Tissue Engineering and Drug Testing Applications . Tissue Engineering Part B: Reviews 22:6, pages 470-484.
Crossref
Zen Liu & Gordana Vunjak-Novakovic. (2016) Modeling tumor microenvironments using custom-designed biomaterial scaffolds. Current Opinion in Chemical Engineering 11, pages 94-105.
Crossref
Kerim B. Kaylan, Stefan D. Gentile, Lauren E. Milling, Kaustubh N. Bhinge, Farhad Kosari & Gregory H. Underhill. (2016) Mapping lung tumor cell drug responses as a function of matrix context and genotype using cell microarrays. Integrative Biology 8:12, pages 1221-1231.
Crossref
Simon J. Hogg, John J. Evans, Peter H. Sykes & Kenny Chitcholtan. (2015) A method to investigate the anti-metabolic activity of anti-cancer agents on ovarian cancer cells cultured in a 96-well high throughput format. Journal of Ovarian Research 8:1.
Crossref
Mariana R. Carvalho, Daniela Lima, Rui L. Reis, Vitor M. Correlo & Joaquim M. Oliveira. (2015) Evaluating Biomaterial- and Microfluidic-Based 3D Tumor Models. Trends in Biotechnology 33:11, pages 667-678.
Crossref
XI LIANG, XUEQING XU, FENGCHAO WANG, XUEDAN CHEN, NI LI, CANCAN WANG & JIANMING HE. (2015) E-cadherin knockdown increases β-catenin reducing colorectal cancer chemosensitivity only in three-dimensional cultures. International Journal of Oncology 47:4, pages 1517-1527.
Crossref
Kathleen A. Fitzgerald, Meenakshi Malhotra, Caroline M. Curtin, Fergal J. O' Brien & Caitriona M. O' Driscoll. (2015) Life in 3D is never flat: 3D models to optimise drug delivery. Journal of Controlled Release 215, pages 39-54.
Crossref
Rui Li, Alexandra Rodriguez, David R. Nisbet, Colin J. Barrow & Richard J. Williams. 2015. Micro and Nanofabrication Using Self-Assembled Biological Nanostructures. Micro and Nanofabrication Using Self-Assembled Biological Nanostructures 33 61 .
Mireia Alemany-Ribes & Carlos E. Semino. (2014) Bioengineering 3D environments for cancer models. Advanced Drug Delivery Reviews 79-80, pages 40-49.
Crossref
Xian Xu, Mary C. Farach-Carson & Xinqiao Jia. (2014) Three-dimensional in vitro tumor models for cancer research and drug evaluation. Biotechnology Advances 32:7, pages 1256-1268.
Crossref
Ravindra P. Singh, Jeong-Woo Choi, Ashutosh Tiwari & Avinash Chand Pandey. 2014. Biosensors Nanotechnology. Biosensors Nanotechnology 141 197 .
Tianzhu Zhang, Qiying Zhang, Junsong Chen, Kun Fang, Jun Dou & Ning Gu. (2014) The controllable preparation of porous PLGA microspheres by the oil/water emulsion method and its application in 3D culture of ovarian cancer cells. Colloids and Surfaces A: Physicochemical and Engineering Aspects 452, pages 115-124.
Crossref
Elke Kaemmerer, Ferry P.W. Melchels, Boris M. Holzapfel, Tobias Meckel, Dietmar W. Hutmacher & Daniela Loessner. (2014) Gelatine methacrylamide-based hydrogels: An alternative three-dimensional cancer cell culture system. Acta Biomaterialia 10:6, pages 2551-2562.
Crossref
Paula Cunnea & Euan A. Stronach. (2014) Modeling Platinum Sensitive and Resistant High-Grade Serous Ovarian Cancer: Development and Applications of Experimental Systems. Frontiers in Oncology 4.
Crossref
Wen Xu, Xinlei Hu & Wensheng Pan. (2014) Tissue Engineering Concept in the Research of the Tumor Biology. Technology in Cancer Research & Treatment 13:2, pages 149-159.
Crossref
Wei‐Bin Shi, Van‐Minh Le, Chun‐Hua Gu, Yuan‐Hong Zheng, Mei‐Dong Lang, Yan‐Hua Lu & Jian‐Wen Liu. (2014) Overcoming Multidrug Resistance in 2D and 3D Culture Models by Controlled Drug Chitosan‐Graft Poly(Caprolactone)‐Based Nanoparticles. Journal of Pharmaceutical Sciences 103:4, pages 1064-1074.
Crossref
Emily Suzanne Fuller & Viive Maarika Howell. (2014) Culture Models to Define Key Mediators of Cancer Matrix Remodeling. Frontiers in Oncology 4.
Crossref
I. Levinger, Y. Ventura & R. Vago. 2014. 383 414 .
Yongzhu Chen, Chengkang Tang, Zhihua Xing, Jie Zhang & Feng Qiu. (2013) Ethanol induced the formation of β -sheet and amyloid-like fibrils by surfactant-like peptide A6K . Journal of Peptide Science 19:11, pages 708-716.
Crossref
Janet Myungjin Lee, Paulette Mhawech-Fauceglia, Nathan Lee, Lucineh Cristina Parsanian, Yvonne Gail Lin, Simon Andrew Gayther & Kate Lawrenson. (2013) A three-dimensional microenvironment alters protein expression and chemosensitivity of epithelial ovarian cancer cells in vitro. Laboratory Investigation 93:5, pages 528-542.
Crossref
Tianzhu Zhang, Junsong Chen, Qiying Zhang, Jun Dou & Ning Gu. (2013) Poly(ethylene glycol)-cross linked poly(methyl vinyl ether-co-maleic acid)hydrogels for three-dimensional human ovarian cancer cell culture. Colloids and Surfaces A: Physicochemical and Engineering Aspects 422, pages 81-89.
Crossref
Ravindra P. Singh, Jeong -Woo Choi, Ashutosh Tiwari & Avinash Chand Pandey. 2012. Biomedical Materials and Diagnostic Devices. Biomedical Materials and Diagnostic Devices 215 262 .
Radhika Deshmukh & Hemant J. Purohit. (2012) Peptide Scaffolds: Flexible Molecular Structures With Diverse Therapeutic Potentials. International Journal of Peptide Research and Therapeutics 18:2, pages 125-143.
Crossref
Elizabeth C. Wu, Shuguang Zhang & Charlotte A. E. Hauser. (2012) Self-Assembling Peptides as Cell-Interactive Scaffolds. Advanced Functional Materials 22:3, pages 456-468.
Crossref
Jingping Liu & Xiaojun Zhao. (2011) Design of self-assembling peptides and their biomedical applications. Nanomedicine 6:9, pages 1621-1643.
Crossref

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.