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Original Research

Enhanced oral absorption of pemetrexed by ion-pairing complex formation with deoxycholic acid derivative and multiple nanoemulsion formulations: preparation, characterization, and in vivo oral bioavailability and anticancer effect

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Pages 3329-3351 | Published online: 06 Jun 2018

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Deepika Radhakrishnan, Vaishwik Patel, Shan Mohanan, Sharon Wong, Jacob Netherton, Ajay Karakoti & Ajayan Vinu. (2023) Combinatorial treatment using bevacizumab/pemetrexed loaded core-shell silica nanoparticles for non-small cell lung cancer. Science and Technology of Advanced Materials 24:1.
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Marija Gvoic, Sasa Vukmirovic, Hani Al-Salami, Armin Mooranian, Momir Mikov & Karmen Stankov. (2021) Bile acids as novel enhancers of CNS targeting antitumor drugs: a comprehensive review. Pharmaceutical Development and Technology 26:6, pages 617-633.
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Ruby Maharjan, Laxman Subedi, Rudra Pangeni, Saurav Kumar Jha, Seo Hee Kang, Kwan-Young Chang, Youngro Byun, Jeong Uk Choi & Jin Woo Park. (2021) Metronomic delivery of orally available pemetrexed-incorporated colloidal dispersions for boosting tumor-specific immunity. Drug Delivery 28:1, pages 2313-2328.
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Rudra Pangeni, Saurav Kumar Jha, Ruby Maharjan, Jeong Uk Choi, Kwan-Young Chang, Young Kweon Choi, Youngro Byun & Jin Woo Park. (2019) Intestinal transport mechanism and in vivo anticancer efficacy of a solid oral formulation incorporating an ion-pairing complex of pemetrexed with deoxycholic acid derivative. International Journal of Nanomedicine 14, pages 6339-6356.
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Xiong-Bin Hu, Tian-Tian Tang, Yong-Jiang Li, Jun-Yong Wu, Jie-Min Wang, Xin-Yi Liu & Da-Xiong Xiang. (2019) Phospholipid complex based nanoemulsion system for oral insulin delivery: preparation, in vitro, and in vivo evaluations. International Journal of Nanomedicine 14, pages 3055-3067.
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