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International Journal of Nanomedicine Volume 14, 2019 - Issue
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Original Research

G1-S4 or G2-S16 carbosilane dendrimer in combination with Platycodin D as a promising vaginal microbicide candidate with contraceptive activity

Rafael Ceña-Diez1 Immunology Section, Head Inmuno-Biology Molecular Laboratory, Gregorio Marañón University General Hospital, Gregorio Marañón Health Research Institute (IiSGM), Spanish HIV HGM BioBank, Madrid, Spain, [email protected];2 Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain, [email protected]
,
Alba Martin-Moreno1 Immunology Section, Head Inmuno-Biology Molecular Laboratory, Gregorio Marañón University General Hospital, Gregorio Marañón Health Research Institute (IiSGM), Spanish HIV HGM BioBank, Madrid, Spain, [email protected]
,
F Javier de la Mata2 Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain, [email protected];3 Organic and Inorganic Chemistry Department, Alcalá University, Alcalá de Henares, Spain
,
Rafael Gómez-Ramirez2 Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain, [email protected];3 Organic and Inorganic Chemistry Department, Alcalá University, Alcalá de Henares, Spain
,
Eduardo Muñoz4 Department of Cell Biology, Physiology and Immunology, Instituto Maimónides de Investigación Biomédicas de Córdoba (IMIBIC), Reina Sofía University Hospital, University of Córdoba, Córdoba, Spain
,
Manuel Ardoy5 Human Reproduction Unit, Gregorio Marañon University General Hospital, Madrid, Spain
&
Ma Ángeles Muñoz-Fernández1 Immunology Section, Head Inmuno-Biology Molecular Laboratory, Gregorio Marañón University General Hospital, Gregorio Marañón Health Research Institute (IiSGM), Spanish HIV HGM BioBank, Madrid, Spain, [email protected];2 Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain, [email protected]Correspondence[email protected]
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Pages 2371-2381 | Published online: 02 Apr 2019

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Trinette Fernandes, Krishna Baxi, Sujata Sawarkar, Bruno Sarmento & José das Neves. (2020) Vaginal multipurpose prevention technologies: promising approaches for enhancing women’s sexual and reproductive health. Expert Opinion on Drug Delivery 17:3, pages 379-393.
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Articles from other publishers (14)

Rafael Ceña-Diez, Aswathy Narayanan, Shilpa Ray, Maarten van de Klundert, Jimmy E Rodriguez, Johan Nilvebrant, Per-Åke Nygren, Ákos Végvári, Robert van Domselaar & Anders Sönnerborg. (2023) Naturally occurring dipeptide from elite controllers with dual anti-HIV-1 mechanism. International Journal of Antimicrobial Agents 61:5, pages 106792.
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Francisco Javier de la Mata, Rafael Gómez, Jesús Cano, Javier Sánchez‐Nieves, Paula Ortega & Sandra García Gallego. (2022) Carbosilane dendritic nanostructures, highly versatile platforms for pharmaceutical applications. WIREs Nanomedicine and Nanobiotechnology 15:3.
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Long Xie, Yu-Xin Zhao, Yu Zheng & Xiao-Fang Li. (2023) The pharmacology and mechanisms of platycodin D, an active triterpenoid saponin from Platycodon grandiflorus. Frontiers in Pharmacology 14.
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Ignacio Rodríguez‐Izquierdo, Daniel Sepúlveda‐Crespo, Jose María Lasso, Salvador Resino & Ma Ángeles Muñoz‐Fernández. (2022) Baseline and time‐updated factors in preclinical development of anionic dendrimers as successful anti‐HIV ‐1 vaginal microbicides . WIREs Nanomedicine and Nanobiotechnology 14:3.
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Qianqian Li, Tan Yang, Shuang Zhao, Qifeng Zheng, Yaxin Li, Zhiyuan Zhang, Xiuyan Sun, Yan Liu, Yanqing Zhang & Junbo Xie. (2022) Distribution, Biotransformation, Pharmacological Effects, Metabolic Mechanism and Safety Evaluation of Platycodin D: A Comprehensive Review. Current Drug Metabolism 23:1, pages 21-29.
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E. Royo-Rubio, I. Rodríguez-Izquierdo, M. Moreno-Domene, T. Lozano-Cruz, F. J. de la Mata, R. Gómez, M. A. Muñoz-Fernández & J. L. Jiménez. (2021) Promising PEGylated cationic dendrimers for delivery of miRNAs as a possible therapy against HIV-1 infection. Journal of Nanobiotechnology 19:1.
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I. Relaño-Rodríguez, M. S. Espinar-Buitrago, V. Martín-Cañadilla, R. Gómez-Ramirez, J. L. Jiménez & M. A. Muñoz-Fernández. (2021) Nanotechnology against human cytomegalovirus in vitro: polyanionic carbosilane dendrimers as antiviral agents. Journal of Nanobiotechnology 19:1.
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Ignacio Relaño-Rodríguez, María de la Sierra Espinar-Buitrago, Vanessa Martín-Cañadilla, Rafael Gómez-Ramírez & María Ángeles Muñoz-Fernández. (2021) G2-S16 Polyanionic Carbosilane Dendrimer Can Reduce HIV-1 Reservoir Formation by Inhibiting Macrophage Cell to Cell Transmission. International Journal of Molecular Sciences 22:16, pages 8366.
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M. de la Sierra Espinar Buitrago & M. Ángeles Muñoz Fernández. 2021. Dendrimer-Based Nanotherapeutics. Dendrimer-Based Nanotherapeutics 163 182 .
Esmat Jalalvandi, Hafez Jafari, Christiani A. Amorim, Denise Freitas Siqueira Petri, Lei Nie & Amin Shavandi. (2020) Vaginal Administration of Contraceptives. Scientia Pharmaceutica 89:1, pages 3.
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Ignacio Relaño-Rodríguez & Maria Ángeles Muñoz-Fernández. (2020) Emergence of Nanotechnology to Fight HIV Sexual Transmission: The Trip of G2-S16 Polyanionic Carbosilane Dendrimer to Possible Pre-Clinical Trials. International Journal of Molecular Sciences 21:24, pages 9403.
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Micaela A. Macchione, Dariana Aristizabal Bedoya, Francisco N. Figueroa, María Ángeles Muñoz-Fernández & Miriam C. Strumia. (2020) Nanosystems Applied to HIV Infection: Prevention and Treatments. International Journal of Molecular Sciences 21:22, pages 8647.
Crossref
Christian Bailly & Gérard Vergoten. (2020) Proposed mechanisms for the extracellular release of PD-L1 by the anticancer saponin platycodin D. International Immunopharmacology 85, pages 106675.
Crossref
Ignacio Rodriguez-Izquierdo, Samanta Gasco & Maria Angeles Muñoz-Fernández. (2020) High Preventive Effect of G2-S16 Anionic Carbosilane Dendrimer against Sexually Transmitted HSV-2 Infection. Molecules 25:13, pages 2965.
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