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Original Research

Strategic approach to developing a self-microemulsifying drug delivery system to enhance antiplatelet activity and bioavailability of ticagrelor

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Pages 1193-1212 | Published online: 15 Feb 2019

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Nariman Shahid, Alia Erum, Muhammad Zaman, Ume Ruqia Tulain, Qurat-ul-ain Shoaib, Nadia Shamshad Malik, Rizwana Kausar, Ayesha Rashid & Umaira Rehman. (2022) Synthesis and evaluation of chitosan based controlled release nanoparticles for the delivery of ticagrelor. Designed Monomers and Polymers 25:1, pages 55-63.
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Nariman Shahid, Alia Erum, Muhammad Zaman, Ume Ruqia Tulain, Qurat-ul-ain Shoaib, Abdul Majeed, Muhammad F Rasool, Imran Imran, Sultan Alshehri, Behnam Noorani & Faleh Alqahtani. (2021) pH-Responsive Nanocomposite Based Hydrogels for the Controlled Delivery of Ticagrelor; In Vitro and In Vivo Approaches. International Journal of Nanomedicine 16, pages 6345-6366.
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Mingzhuo Cao, Mengling Zhan, Zheng Wang, Zeqian Wang, Xiu-Min Li & Mingsan Miao. (2020) Development of an Orally Bioavailable Isoliquiritigenin Self-Nanoemulsifying Drug Delivery System to Effectively Treat Ovalbumin-Induced Asthma. International Journal of Nanomedicine 15, pages 8945-8961.
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Articles from other publishers (23)

Chien-Ming Hsieh, Ting-Lun Yang, Athika Darumas Putri & Chin-Tin Chen. (2023) Application of Design of Experiments in the Development of Self-Microemulsifying Drug Delivery Systems. Pharmaceuticals 16:2, pages 283.
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Devender Kumar, Sushama Talegaonkar, Simrata Bedi & Kiran Dubey. (2023) Design, development and evaluation of self-microemulsifying drug delivery system of pazopanib for enhanced dissolution rate and cytotoxic potential. Journal of Drug Delivery Science and Technology 80, pages 104181.
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Fan Zhang, Xiaofei Wu, Keheng Wu, Mengyang Yu, Bo Liu & Hongyun Wang. (2022) Predicting the Pharmacokinetics of Orally Administered Drugs across BCS Classes 1–4 by Virtual Bioequivalence Model. Molecular Pharmaceutics 20:1, pages 395-408.
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Jeong Sun Sohn & Jin-Seok Choi. (2022) A study on the improved dissolution and permeability of ticagrelor with sodium oleate in a ternary system. Journal of Molecular Liquids 361, pages 119685.
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Arshad Ali Khan, Akhtar Atiya, Safia Akhtar, Yogesh Yadav, Kamal A. Qureshi, Mariusz Jaremko & Syed Mahmood. (2022) Optimization of a Cefuroxime Axetil-Loaded Liquid Self-Nanoemulsifying Drug Delivery System: Enhanced Solubility, Dissolution and Caco-2 Cell Uptake. Pharmaceutics 14:4, pages 772.
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Renu Kadian & Arun Nanda. (2022) A Comprehensive Insight on Self Emulsifying Drug Delivery Systems. Recent Advances in Drug Delivery and Formulation 16:1, pages 16-44.
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Nariman Shahid, Alia Erum, Muhammad Zaman, Muhammad Omer Iqbal, Romana Riaz, Ruqia Tulain, Tousif Hussain, Muhammad W Amjad, Maria AG Raja, Umer Farooq & Waqar Aman. (2022) Fabrication of thiolated chitosan based biodegradable nanoparticles of ticagrelor and their pharmacokinetics. Polymers and Polymer Composites 30, pages 096739112211087.
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Mohamed Fawzy Kabil, Ahmed S. Abo Dena & Ibrahim M. El-Sherbiny. 2022. 91 111 .
Ingrid Langer & Dorota Latek. (2021) Drug Repositioning For Allosteric Modulation of VIP and PACAP Receptors. Frontiers in Endocrinology 12.
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Mukesh Yadav, Jayant Sarolia, Bhavin Vyas, Manisha Lalan, Shubhada Mangrulkar & Pranav Shah. (2021) Amalgamation of Solid Dispersion and Melt Adsorption Technique: Improved In Vitro and In Vivo Performance of Ticagrelor Tablets. AAPS PharmSciTech 22:8.
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Nafiseh Hosseini‐Ashtiani & Azadeh Tadjarodi. (2021) Design and Characterization of Ticagrelor‐Loaded Chitosan Biopolymer to Improve Chemical and Biological Properties of the Drug. ChemistrySelect 6:8, pages 1741-1747.
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Mo-Ran Sun, Hong-Liang Li, Meng-Yu Ba, Weyland Cheng, Hai-Liang Zhu & Yong-Tao Duan. (2021) Cyclopropyl Scaffold: A Generalist for Marketed Drugs. Mini-Reviews in Medicinal Chemistry 21:2, pages 150-170.
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Pragya Yadav, Vaibhav Rastogi & Anurag Verma. (2020) Application of Box–Behnken design and desirability function in the development and optimization of self-nanoemulsifying drug delivery system for enhanced dissolution of ezetimibe. Future Journal of Pharmaceutical Sciences 6:1.
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Ruiming Li, Yong Wang, Qiang Yang, Baolong Lai, Xie Zhou & Min Feng. (2020) Enhanced Stability of the Pharmacologically Active Lactone Form of 10-Hydroxycamptothecin by Self-Microemulsifying Drug Delivery Systems. AAPS PharmSciTech 21:8.
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Miao Wang, Sung-Kyun You, Hong-Ki Lee, Min-Gu Han, Hyeon-Min Lee, Thi Mai Anh Pham, Young-Guk Na & Cheong-Weon Cho. (2020) Development and Evaluation of Docetaxel-Phospholipid Complex Loaded Self-Microemulsifying Drug Delivery System: Optimization and In Vitro/Ex Vivo Studies. Pharmaceutics 12:6, pages 544.
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Young-Guk Na, Thi Mai Anh Pham, Jin-Ju Byeon, Min-Ki Kim, Min-Gu Han, Jong-Suep Baek, Hong-Ki Lee & Cheong-Weon Cho. (2020) Development and evaluation of TPGS/PVA-based nanosuspension for enhancing dissolution and oral bioavailability of ticagrelor. International Journal of Pharmaceutics 581, pages 119287.
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Young-Guk Na, Jin-Ju Byeon, Min-Ki Kim, Min-Gu Han, Cheong-Weon Cho, Jong-Suep Baek, Hong-Ki Lee & Young G. Shin. (2020) Pharmacokinetic/Pharmacodynamic Modeling To Predict the Antiplatelet Effect of the Ticagrelor-Loaded Self-Microemulsifying Drug Delivery System in Rats. Molecular Pharmaceutics 17:4, pages 1079-1089.
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Sung-Jin Kim, Bongkyun Park, Hyun Wook Huh, Young-Guk Na, Minki Kim, Mingu Han, Hyunmin Lee, Thi Mai Anh Pham, Hong-Ki Lee, Jae-Young Lee, Chan-Sik Kim, Jong-Suep Baek & Cheong-Weon Cho. (2020) Achyranthis radix Extract-Loaded Eye Drop Formulation Development and Novel Evaluation Method for Dry Eye Treatment. Pharmaceutics 12:2, pages 165.
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Yongtai Zhang, Kai Zhang, Zhi Wang, Hongmei Hu, Qian Jing, Yanyan Li, Teng Guo & Nianping Feng. (2019) Transcutol® P/Cremophor® EL/Ethyl Oleate–Formulated Microemulsion Loaded into Hyaluronic Acid–Based Hydrogel for Improved Transdermal Delivery and Biosafety of Ibuprofen. AAPS PharmSciTech 21:1.
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Young-Guk Na, Sung-Hoon Jeon, Jin-Ju Byeon, Min-Ki Kim, Hong-Ki Lee & Cheong-Weon Cho. (2019) Application of statistical design on the early development of sustained-release tablet containing ivy leaf extract. Journal of Drug Delivery Science and Technology 54, pages 101319.
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Young-Guk Na, Jin-Ju Byeon, Miao Wang, Hyun Wook Huh, Min-Ki Kim, Ki-Hyun Bang, Min-Gu Han, Hong-Ki Lee & Cheong-Weon Cho. (2019) Statistical approach for solidifying ticagrelor loaded self-microemulsifying drug delivery system with enhanced dissolution and oral bioavailability. Materials Science and Engineering: C 104, pages 109980.
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Young-Guk Na, Jin-Ju Byeon, Hyun Wook Huh, Min-Ki Kim, Young G. Shin, Hong-Ki Lee & Cheong-Weon Cho. (2019) Effect of Ticagrelor, a Cytochrome P450 3A4 Inhibitor, on the Pharmacokinetics of Tadalafil in Rats. Pharmaceutics 11:7, pages 354.
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Gi-Ho Son, Young-Guk Na, Hyun Wook Huh, Miao Wang, Min-Ki Kim, Min-Gu Han, Jin-Ju Byeon, Hong-Ki Lee & Cheong-Weon Cho. (2019) Systemic Design and Evaluation of Ticagrelor-Loaded Nanostructured Lipid Carriers for Enhancing Bioavailability and Antiplatelet Activity. Pharmaceutics 11:5, pages 222.
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