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International Journal of Nanomedicine Volume 14, 2019 - Issue
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Original Research

Nano-scaled MTCA-KKV: for targeting thrombus, releasing pharmacophores, inhibiting thrombosis and dissolving blood clots in vivo

Shurui Zhao1 Beijing Area Major Laboratory of Peptide and Small Molecular Drugs, Engineering Research Center of Endogenous Prophylactic of Ministry of Education of China, Beijing Laboratory of Biomedical Materials, College of Pharmaceutical Sciences, Capital Medical University, Beijing100069, People’s Republic of China
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Ze Li1 Beijing Area Major Laboratory of Peptide and Small Molecular Drugs, Engineering Research Center of Endogenous Prophylactic of Ministry of Education of China, Beijing Laboratory of Biomedical Materials, College of Pharmaceutical Sciences, Capital Medical University, Beijing100069, People’s Republic of China
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Fei Huang2 Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, People’s Republic of China
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Jianhui Wu1 Beijing Area Major Laboratory of Peptide and Small Molecular Drugs, Engineering Research Center of Endogenous Prophylactic of Ministry of Education of China, Beijing Laboratory of Biomedical Materials, College of Pharmaceutical Sciences, Capital Medical University, Beijing100069, People’s Republic of China
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Lin Gui1 Beijing Area Major Laboratory of Peptide and Small Molecular Drugs, Engineering Research Center of Endogenous Prophylactic of Ministry of Education of China, Beijing Laboratory of Biomedical Materials, College of Pharmaceutical Sciences, Capital Medical University, Beijing100069, People’s Republic of China
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Xiaoyi Zhang1 Beijing Area Major Laboratory of Peptide and Small Molecular Drugs, Engineering Research Center of Endogenous Prophylactic of Ministry of Education of China, Beijing Laboratory of Biomedical Materials, College of Pharmaceutical Sciences, Capital Medical University, Beijing100069, People’s Republic of China
,
Yaonan Wang1 Beijing Area Major Laboratory of Peptide and Small Molecular Drugs, Engineering Research Center of Endogenous Prophylactic of Ministry of Education of China, Beijing Laboratory of Biomedical Materials, College of Pharmaceutical Sciences, Capital Medical University, Beijing100069, People’s Republic of China
,
Xiaozhen Wang1 Beijing Area Major Laboratory of Peptide and Small Molecular Drugs, Engineering Research Center of Endogenous Prophylactic of Ministry of Education of China, Beijing Laboratory of Biomedical Materials, College of Pharmaceutical Sciences, Capital Medical University, Beijing100069, People’s Republic of China
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Shiqi Peng1 Beijing Area Major Laboratory of Peptide and Small Molecular Drugs, Engineering Research Center of Endogenous Prophylactic of Ministry of Education of China, Beijing Laboratory of Biomedical Materials, College of Pharmaceutical Sciences, Capital Medical University, Beijing100069, People’s Republic of China
&
Ming Zhao1 Beijing Area Major Laboratory of Peptide and Small Molecular Drugs, Engineering Research Center of Endogenous Prophylactic of Ministry of Education of China, Beijing Laboratory of Biomedical Materials, College of Pharmaceutical Sciences, Capital Medical University, Beijing100069, People’s Republic of ChinaCorrespondence[email protected]
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Pages 4817-4831 | Published online: 03 Jul 2019

Citations (7)

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Qiqi Feng, Mengyang Wang, Eldar Muhtar, Yaonan Wang & Haimei Zhu. (2021) Nanoparticles of a New Small-Molecule P-Selectin Inhibitor Attenuate Thrombosis, Inflammation, and Tumor Growth in Two Animal Models. International Journal of Nanomedicine 16, pages 5777-5795.
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Articles from other publishers (6)

Jun Liao, Li Fan, Yi Li, Qing-Qiang Xu, Li-Yan Xiong, Shan-Shan Zhang, Ji-Hao Liu, Zhi-Cheng Xiao, Chuan Zhang, Jian Yang, Zhe-Sheng Chen, Kai Xiao, Ting-Fang Wang & Ying Lu. (2023) Recent advances in biomimetic nanodelivery systems: New brain-targeting strategies. Journal of Controlled Release 358, pages 439-464.
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Jia‐Wei Zhang, Xuan Meng, Tao Han, Xiaofei Wei, Liang Wang, Yu Zhao, Geng Fu, Ning Tian, Qian Wang, Sichen Qin, Xiaoxu Liu & Chatchai Putson. (2023) Optical magnetic field sensors based on nanodielectrics: From biomedicine to IoT‐based energy internet. IET Nanodielectrics.
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Shuangling Chen, Meng Liang, Chengli Wu, Xiaoyi Zhang, Yuji Wang & Ming Zhao. (2023) Poly-α, β-d, l-Aspartyl-Arg-Gly-Asp-Ser-Based Urokinase Nanoparticles for Thrombolysis Therapy. Molecules 28:6, pages 2578.
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Xiaoyi Zhang, Yifan Yang, Yuji Wang, Jianhui Wu, Qiongyan Fang, Yaonan Wang, Ming Zhao & Shiqi Peng. (2022) (1R,3S)-THCCA-Asn: To show the discovery of selective inhibitor of thrombin by successfully combining virtual screening and biological assay. European Journal of Medicinal Chemistry 242, pages 114681.
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Shanshan Zhang, Yuan Zhou, Ruoqi Li, Zhong Chen & Xiang Fan. (2022) Advanced drug delivery system against ischemic stroke. Journal of Controlled Release 344, pages 173-201.
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Junchao Xu, Yinlong Zhang & Guangjun Nie. (2021) Intelligent antithrombotic nanomedicines: Progress, opportunities, and challenges. View 2:2, pages 20200145.
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