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International Journal of Nanomedicine Volume 14, 2019 - Issue
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Original Research

Repeated intravenous administration of silica nanoparticles induces pulmonary inflammation and collagen accumulation via JAK2/STAT3 and TGF-β/Smad3 pathways in vivo

Yang Yu1 Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing, People’s Republic of China;2 Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, People’s Republic of China
,
Tingting Zhu1 Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing, People’s Republic of China
,
Yang Li1 Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing, People’s Republic of China;2 Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, People’s Republic of China
,
Li Jing1 Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing, People’s Republic of China;2 Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, People’s Republic of China
,
Man Yang1 Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing, People’s Republic of China;2 Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, People’s Republic of China
,
Yanbo Li1 Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing, People’s Republic of China;2 Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, People’s Republic of China
,
Junchao Duan1 Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing, People’s Republic of China;2 Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, People’s Republic of China
&
Zhiwei Sun1 Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing, People’s Republic of China;2 Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, People’s Republic of ChinaCorrespondence[email protected] [email protected]
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Pages 7237-7247 | Published online: 06 Sep 2019

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Yan Li, Yawen Zhu, Bosen Zhao, Qing Yao, Hailin Xu, Songqing Lv, Ji Wang, Zhiwei Sun, Yanbo Li & Caixia Guo. (2022) Amorphous silica nanoparticles caused lung injury through the induction of epithelial apoptosis via ROS/Ca2+/DRP1-mediated mitochondrial fission signaling. Nanotoxicology 16:6-8, pages 713-732.
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Lu Cao, Peng Qin, Jianjiang Zhang, Huiju Qiao, Peipei Shi & Huali Huo. (2020) LncRNA PVT1 Suppresses the Progression of Renal Fibrosis via Inactivation of TGF-β Signaling Pathway. Drug Design, Development and Therapy 14, pages 3547-3557.
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Moumita Rakshit, Archana Gautam, Li Zhen Toh, Ying Shi Lee, Hui Ying Lai, Tina T Wong & Kee Woei Ng. (2020) Hydroxyapatite Particles Induced Modulation of Collagen Expression and Secretion in Primary Human Dermal Fibroblasts. International Journal of Nanomedicine 15, pages 4943-4956.
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Articles from other publishers (13)

Yong Yu, Li-Kun Xia, Yu Di, Qing-Zhu Nie & Xiao-Long Chen. (2023) Mechanism of piR-1245/PIWI-like protein-2 regulating Janus kinase-2/signal transducer and activator of transcription-3/vascular endothelial growth factor signaling pathway in retinal neovascularization. Neural Regeneration Research 18:5, pages 1132.
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Yiping Liu, Ming Hu, Guanzhi Fan, Nanshu Xing & Rong Zhang. (2022) Effect of Baricitinib on the epithelial-mesenchymal transition of alveolar epithelial cells induced by IL-6. International Immunopharmacology 110, pages 109044.
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Na Liang, Na Ren, Zhichao Feng, Zhaoyang Sun, Mengwei Dong, Wenhan Wang, Feng Liu, Chunhui Sun, Weijia Zhou, Zhiqing Xing, Jingang Wang, Chao Liu & Hong Liu. (2022) Biomimetic Metal−Organic Frameworks as Targeted Vehicles to Enhance Osteogenesis. Advanced Healthcare Materials 11:12, pages 2102821.
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Yuexiao Ma, Qingqing Liang, Fenghong Wang, Kanglin Yan, Mengqi Sun, Lisen Lin, Tianyu Li, Junchao Duan & Zhiwei Sun. (2022) Silica nanoparticles induce pulmonary autophagy dysfunction and epithelial-to-mesenchymal transition via p62/NF-κB signaling pathway. Ecotoxicology and Environmental Safety 232, pages 113303.
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Clodoveo Ferri, Maria-Cristina Arcangeletti, Elisabetta Caselli, Krystyna Zakrzewska, Clara Maccari, Adriana Calderaro, Maria D'Accolti, Irene Soffritti, Rosaria Arvia, Gianluca Sighinolfi, Erica Artoni & Dilia Giuggioli. (2021) Insights into the knowledge of complex diseases: Environmental infectious/toxic agents as potential etiopathogenetic factors of systemic sclerosis. Journal of Autoimmunity 124, pages 102727.
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Xinying Zhao, Alimire Abulikemu, Songqing Lv, Yi Qi, Junchao Duan, Jie Zhang, Rui Chen, Caixia Guo, Yanbo Li & Zhiwei Sun. (2021) Oxidative stress- and mitochondrial dysfunction-mediated cytotoxicity by silica nanoparticle in lung epithelial cells from metabolomic perspective. Chemosphere 275, pages 129969.
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Haoyu Yin, Junxia Li, Jiaqi Tian, Lan Ma, Jing Zhang, Qingfeng Zhai, Sanqiao Yao & Lin Zhang. (2021) Uterine pyruvate metabolic disorder induced by silica nanoparticles act through the pentose phosphate pathway. Journal of Hazardous Materials 412, pages 125234.
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Xin Yi, Jie Liu, Mo-sha Cheng & Qing Zhou. (2021) Low-intensity pulsed ultrasound inhibits IL-6 in subchondral bone of temporomandibular joint osteoarthritis by suppressing the TGF-β1/Smad3 pathway. Archives of Oral Biology 125, pages 105110.
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Yang Lan, Cheng Teng Ng, Choon Nam Ong, Liya E. Yu & Boon Huat Bay. (2021) Transcriptomic analysis identifies dysregulated genes and functional networks in human small airway epithelial cells exposed to ambient PM2.5. Ecotoxicology and Environmental Safety 208, pages 111702.
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Atefe Rezaei, Marjan Daeihamed, Esra Capanoglu, Merve Tomas, Safoura Akbari-Alavijeh, Rezvan Shaddel, Sara Khoshnoudi-Nia, Sareh Boostani, Hadis Rostamabadi, Seid Reza Falsafi & Seid Mahdi Jafari. 2021. Safety and Regulatory Issues of Nanoencapsulated Food Ingredients. Safety and Regulatory Issues of Nanoencapsulated Food Ingredients 31 118 .
Zelai He, Huijun Zhang, Hongwei Li, Yanyan Wang, Jing Qian, Xixi Cai, Li Sun & Jingwen Huang. (2020) Preparation, Biosafety, and Cytotoxicity Studies of a Newly Tumor-Microenvironment-Responsive Biodegradable Mesoporous Silica Nanosystem Based on Multimodal and Synergistic Treatment. Oxidative Medicine and Cellular Longevity 2020, pages 1-14.
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Raziye Mohammadpour, Darwin L. Cheney, Jason W. Grunberger, Mostafa Yazdimamaghani, Jolanta Jedrzkiewicz, Kyle J. Isaacson, Marina A. Dobrovolskaia & Hamidreza Ghandehari. (2020) One-year chronic toxicity evaluation of single dose intravenously administered silica nanoparticles in mice and their Ex vivo human hemocompatibility. Journal of Controlled Release 324, pages 471-481.
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Je-Oh Lim, Na-Rae Shin, Yun-Soo Seo, Hyeon-Hwa Nam, Je-Won Ko, Tae-Yang Jung, Se-Jin Lee, Ha-Jung Kim, Young-Kwon Cho, Jong-Choon Kim, In-Chul Lee, Joong-Sun Kim & In-Sik Shin. (2020) Silibinin Attenuates Silica Dioxide Nanoparticles-Induced Inflammation by Suppressing TXNIP/MAPKs/AP-1 Signaling. Cells 9:3, pages 678.
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