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International Journal of Nanomedicine Volume 14, 2019 - Issue

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Original Research

Synthesis and antitumor activity of novel pyridinium fullerene derivatives

Takumi Yasuno1 Department of Pharmaceutical Sciences, Faculty of Pharmacy, Keio University, Tokyo, Japan

Tomoyuki Ohe1 Department of Pharmaceutical Sciences, Faculty of Pharmacy, Keio University, Tokyo, JapanCorrespondence[email protected] [email protected]

Hitomi Ikeda1 Department of Pharmaceutical Sciences, Faculty of Pharmacy, Keio University, Tokyo, Japan

Kyoko Takahashi1 Department of Pharmaceutical Sciences, Faculty of Pharmacy, Keio University, Tokyo, Japan

Shigeo Nakamura2 Department of Chemistry, Nippon Medical School, Tokyo, Japan

Tadahiko Mashino1 Department of Pharmaceutical Sciences, Faculty of Pharmacy, Keio University, Tokyo, Japan

Pages 6325-6337 | Published online: 07 Aug 2019

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Daiki Katagishi, Daisuke Yasuda, Kyoko Takahashi, Shigeo Nakamura, Tadahiko Mashino & Tomoyuki Ohe. (2023) Fullerene derivatives as inhibitors of the SARS-CoV-2 main protease. Bioorganic & Medicinal Chemistry Letters 80, pages 129121.
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Jiawei Huo, Jie Li, Yang Liu, Libin Yang, Xinran Cao, Chong Zhao, Yicheng Lu, Wei Zhou, Shumu Li, Jianan Liu, Jiao Li, Xing Li, Jing Wan, Rui Wen, Mingming Zhen, Chunru Wang & Chunli Bai. (2022) Amphiphilic Aminated Derivatives of [60]Fullerene as Potent Inhibitors of Tumor Growth and Metastasis. Advanced Science 9:29, pages 2201541.
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Xiaoyan Zhang, Wei Zhou, Yang Liu, Linyu Jin, Jiawei Huo, Yang Yang, Shumu Li, Haijun Ma, Jiao Li, Mingming Zhen, Jie Li & Chunru Wang. (2021) Nanosize aminated fullerene for autophagic flux activation and G0/G1 phase arrest in cancer cells via post-transcriptional regulation. Nano Research 15:4, pages 3346-3355.
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Tadahiko Mashino. (2022) Development of Bio-active Fullerene Derivatives Suitable for Drug医薬品に適した生物活性フラーレン誘導体の創製. YAKUGAKU ZASSHI 142:2, pages 165-179.
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Kazuya Sumi, Kenji Tago, Yosuke Nakazawa, Kyoko Takahashi, Tomoyuki Ohe, Tadahiko Mashino & Megumi Funakoshi-Tago. (2022) A bis-pyridinium fullerene derivative induces apoptosis through the generation of ROS in BCR-ABL-positive leukemia cells. European Journal of Pharmacology 916, pages 174714.
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Kazuya Sumi, Kenji Tago, Yosuke Nakazawa, Kyoko Takahashi, Tomoyuki Ohe, Tadahiko Mashino & Megumi Funakoshi-Tago. (2022) Novel Mechanism by a Bis-Pyridinium Fullerene Derivative to Induce Apoptosis by Enhancing the MEK-ERK Pathway in a Reactive Oxygen Species-Independent Manner in BCR-ABL-Positive Chronic Myeloid Leukemia-Derived K562 Cells. International Journal of Molecular Sciences 23:2, pages 749.
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Ayano Kadota, Misato Moriguchi, Tadashi Watanabe, Yuichi Sekine, Shigeo Nakamura, Takumi Yasuno, Tomoyuki Ohe, Tadahiko Mashino & Masahiro Fujimuro. (2022) A pyridinium‑type fullerene derivative suppresses primary effusion lymphoma cell viability via the downregulation of the Wnt signaling pathway through the destabilization of β‑catenin. Oncology Reports 47:3.
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Tomoyuki Ohe & Tadahiko Mashino. 2022. Handbook of Fullerene Science and Technology. Handbook of Fullerene Science and Technology 889 898 .

Toi Kobayashi, Takumi Yasuno, Kyoko Takahashi, Shigeo Nakamura, Tadahiko Mashino & Tomoyuki Ohe. (2021) Novel pyridinium-type fullerene derivatives as multitargeting inhibitors of HIV-1 reverse transcriptase, HIV-1 protease, and HCV NS5B polymerase. Bioorganic & Medicinal Chemistry Letters 49, pages 128267.
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Takumi Yasuno, Tomoyuki Ohe, Hiroki Kataoka, Kosho Hashimoto, Yumiko Ishikawa, Keigo Furukawa, Yasuhiro Tateishi, Toi Kobayashi, Kyoko Takahashi, Shigeo Nakamura & Tadahiko Mashino. (2021) Fullerene derivatives as dual inhibitors of HIV-1 reverse transcriptase and protease. Bioorganic & Medicinal Chemistry Letters 31, pages 127675.
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Tomoyuki Ohe & Tadahiko Mashino. 2021. Handbook of Fullerene Science and Technology. Handbook of Fullerene Science and Technology 1 10 .

Z. M. Sarkisyan. (2020) Biologically Active Fullerene Derivatives. Russian Journal of General Chemistry 90:10, pages 1853-1862.
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Valerij Kuznetsov. (2020) Stereochemistry of Simple Molecules inside Nanotubes and Fullerenes: Unusual Behavior of Usual Systems. Molecules 25:10, pages 2437.
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Liyun Yang, Siyu Hua, Junpeng Fan, Zhiqiang Zhou, Guanchao Wang, Fenglei Jiang, Zhixiong Xie, Qi Xiao & Yi Liu. (2020) Inhibition of Autophagy via Lysosomal Impairment Enhances Cytotoxicity of Fullerenol under Starvation Condition. ACS Applied Bio Materials 3:2, pages 977-985.
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Synthesis and antitumor activity of novel pyridinium fullerene derivatives

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Synthesis and antitumor activity of novel pyridinium fullerene derivatives

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