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International Journal of Nanomedicine Volume 14, 2019 - Issue
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Original Research

Oral absorption and lymphatic transport of baicalein following drug–phospholipid complex incorporation in self-microemulsifying drug delivery systems

Hengfeng Liao1 State Key Laboratory of Bioactive substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, People’s Republic of China;2 Beijing Key Laboratory of Drug Delivery Technology and Novel Formulation, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing100050, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0002-1854-5514
ORCID Icon,
Yue Gao1 State Key Laboratory of Bioactive substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, People’s Republic of China;2 Beijing Key Laboratory of Drug Delivery Technology and Novel Formulation, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing100050, People’s Republic of China
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Chunfang Lian1 State Key Laboratory of Bioactive substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, People’s Republic of China;2 Beijing Key Laboratory of Drug Delivery Technology and Novel Formulation, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing100050, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0003-0658-0635
ORCID Icon,
Yun Zhang1 State Key Laboratory of Bioactive substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, People’s Republic of China;2 Beijing Key Laboratory of Drug Delivery Technology and Novel Formulation, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing100050, People’s Republic of China
,
Bangyuan Wang1 State Key Laboratory of Bioactive substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, People’s Republic of China;2 Beijing Key Laboratory of Drug Delivery Technology and Novel Formulation, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing100050, People’s Republic of China
,
Yanfang Yang1 State Key Laboratory of Bioactive substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, People’s Republic of China;2 Beijing Key Laboratory of Drug Delivery Technology and Novel Formulation, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing100050, People’s Republic of China
,
Jun Ye1 State Key Laboratory of Bioactive substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, People’s Republic of China;2 Beijing Key Laboratory of Drug Delivery Technology and Novel Formulation, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing100050, People’s Republic of China
,
Yu Feng1 State Key Laboratory of Bioactive substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, People’s Republic of China;2 Beijing Key Laboratory of Drug Delivery Technology and Novel Formulation, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing100050, People’s Republic of China
&
Yuling Liu1 State Key Laboratory of Bioactive substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, People’s Republic of China;2 Beijing Key Laboratory of Drug Delivery Technology and Novel Formulation, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing100050, People’s Republic of ChinaCorrespondence[email protected]
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Pages 7291-7306 | Published online: 06 Sep 2019

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Qing Hu, Xiao-Ling Fu, Yi-Yan Dong, Ju Ma, Jian Hua, Jia-Ting Li, Kai-Xin Liu, Jian Yang & Chang-Xi Yu. (2023) D-Optimal Design and Development of a Koumine-Loaded Microemulsion for Rheumatoid Arthritis Treatment: In vivo and in vitro Evaluation. International Journal of Nanomedicine 18, pages 2973-2988.
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Wai Thet Aung & Veerakiet Boonkanokwong. (2023) Preparation, optimization using a mixture design, and characterization of a novel astaxanthin-loaded rice bran oil self-microemulsifying delivery system formulation. Journal of Dispersion Science and Technology 44:8, pages 1336-1349.
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Yoon Tae Goo, Sangkil Lee, Ji Yeh Choi, Min Song Kim, Gi Hyeong Sin, Sun Ho Hong, Chang Hyun Kim, Seh Hyon Song & Young Wook Choi. (2022) Enhanced oral absorption of insulin: hydrophobic ion pairing and a self-microemulsifying drug delivery system using a D-optimal mixture design. Drug Delivery 29:1, pages 2831-2845.
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Swapna Poudwal & Pravin Shende. (2022) Multi-strategic approaches for enhancing active transportation using self-emulsifying drug delivery system. Journal of Drug Targeting 30:7, pages 726-736.
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Yoon Tae Goo, Cheol-Ki Sa, Min Song Kim, Gi Hyeong Sin, Chang Hyun Kim, Hyeon Kyun Kim, Myung Joo Kang, Sangkil Lee & Young Wook Choi. (2022) Enhanced dissolution and bioavailability of revaprazan using self-nanoemulsifying drug delivery system. Pharmaceutical Development and Technology 27:4, pages 414-424.
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Ravinder Verma, Ajeet Kaushik, Rafa Almeer, Md Habibur Rahman, Mohamed M Abdel-Daim & Deepak Kaushik. (2021) Improved Pharmacodynamic Potential of Rosuvastatin by Self-Nanoemulsifying Drug Delivery System: An in vitro and in vivo Evaluation. International Journal of Nanomedicine 16, pages 905-924.
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Shraddha Srivastava, Abhiram Kumar, Pavan Kumar Yadav, Madhaw Kumar, Jose Mathew, Avinash Chandra Pandey & Manish Kumar Chourasia. (2021) Formulation and performance evaluation of polymeric mixed micelles encapsulated with baicalein for breast cancer treatment. Drug Development and Industrial Pharmacy 47:9, pages 1512-1522.
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Wujun Dong, Jun Ye, Weijue Wang, Yanfang Yang, Hongliang Wang, Tong Sun, Lili Gao & Yuling Liu. (2020) Self-Assembled Lecithin/Chitosan Nanoparticles Based on Phospholipid Complex: A Feasible Strategy to Improve Entrapment Efficiency and Transdermal Delivery of Poorly Lipophilic Drug. International Journal of Nanomedicine 15, pages 5629-5643.
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Articles from other publishers (18)

Shraddha Srivastava, Jose Mathew & Avinash chandra Pandey. (2023) Baicalein—A review on its molecular mechanism against breast cancer and delivery strategies. Medicinal Chemistry Research 32:4, pages 643-658.
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Jilin Wang, Xiaojiao Feng, Ziwei Li, Yiting Liu, Wenzhuo Yang, Tingen Zhang, Pan Guo, Zhidong Liu, Dongli Qi & Jiaxin Pi. (2023) The Flavonoid Components of Scutellaria baicalensis: Biopharmaceutical Properties and their Improvement using Nanoformulation Techniques. Current Topics in Medicinal Chemistry 23:1, pages 17-29.
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Hai-Gang Wu, Xian Wu, Jin-Ni Liu, Pei-Rong Chen, Qing-Ming Qin & Kai-Wei Deng. (2023) Preparation and Evaluation of an Enrofloxacin Self-Micro Emulsion for Veterinary Use. Journal of Biomedical Nanotechnology 19:1, pages 126-138.
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Hengfeng Liao, Jun Ye, Yue Gao, Chunfang Lian, Lu Liu, Xiaoyan Xu, Yu Feng, Yanfang Yang, Yuqi Yang, Qiqi Shen, Lili Gao, Zhihua Liu & Yuling Liu. (2022) Baicalein self‐microemulsion based on drug–phospholipid complex for the alleviation of cytokine storm. Bioengineering & Translational Medicine 8:1.
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Neha Bajwa, Srishti Naryal, Shipra Mahal, Preet Amol Singh & Ashish Baldi. (2022) Quality-by-design strategy for the development of arteether loaded solid self-micro emulsifying drug delivery systems. Journal of Drug Delivery Science and Technology 77, pages 103707.
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Liu Liu, Wenxuan Cao, Mengqiu Xia, Chunling Tian, Wenqing Wu, Ye Cai & Xiaoqin Chu. (2022) Self-Emulsifying Drug Delivery System Enhances Tissue Distribution of Cinnamaldehyde by Altering the Properties of the Mucus Layer. AAPS PharmSciTech 23:7.
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Yutong Wang, Jinyu Huang, Zilin Wang, Xitong Wang, Heng Liu, Xiangwei Li, Hongzhi Qiao, Lingchong Wang, Jing Chen, Xiao Chen & Junsong Li. (2022) Extra virgin olive oil-based phospholipid complex/self-microemulsion enhances oral absorption of salvianolic acid B through inhibition of catechol-O-methyltransferase-mediated metabolism. International Journal of Pharmaceutics 611, pages 121330.
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Mitali Patel & Krutika Sawant. 2022. Pharmacokinetics and Pharmacodynamics of Nanoparticulate Drug Delivery Systems. Pharmacokinetics and Pharmacodynamics of Nanoparticulate Drug Delivery Systems 385 397 .
Shraddha Srivastava, Samipta Singh, Shubhini A. Saraf, Manish K. Chourasia, Jose Mathew & Avinash C. Pandey. (2021) Encapsulation of Baicalein in Cinnamon Essential Oil Nanoemulsion for Enhanced Anticancer Efficacy Against MDA-MB-231 Cells. BioNanoScience 11:4, pages 1049-1060.
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Rou Tang, Rui Li, He Li, Xiao-Lei Ma, Peng Du, Xiao-You Yu, Ling Ren, Lu-Lu Wang & Wen-Sheng Zheng. (2021) Design of Hepatic Targeted Drug Delivery Systems for Natural Products: Insights into Nomenclature Revision of Nonalcoholic Fatty Liver Disease. ACS Nano 15:11, pages 17016-17046.
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Longyun Wang, Qianqian Yin, Cun Liu, Ying Tang, Changgang Sun & Jing Zhuang. (2021) Nanoformulations of Ursolic Acid: A Modern Natural Anticancer Molecule. Frontiers in Pharmacology 12.
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Jun Ye, Yue Gao, Ming Ji, Yanfang Yang, Zhaohui Wang, Baolian Wang, Jing Jin, Ling Li, Hongliang Wang, Xiaoyan Xu, Hengfeng Liao, Chunfang Lian, Yaqi Xu, Renjie Li, Tong Sun, Lili Gao, Yan Li, Xiaoguang Chen & Yuling Liu. (2021) Oral SMEDDS promotes lymphatic transport and mesenteric lymph nodes target of chlorogenic acid for effective T-cell antitumor immunity. Journal for ImmunoTherapy of Cancer 9:7, pages e002753.
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María Plaza-Oliver, Manuel Jesús Santander-Ortega & María Victoria. Lozano. (2021) Current approaches in lipid-based nanocarriers for oral drug delivery. Drug Delivery and Translational Research 11:2, pages 471-497.
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Harsh A. Joshi, Raghavendra S. Patwardhan, Deepak Sharma, Santosh K. Sandur & Padma V. Devarajan. (2021) Pre-clinical evaluation of an innovative oral nano-formulation of baicalein for modulation of radiation responses. International Journal of Pharmaceutics 595, pages 120181.
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Valentina Franco, Pavel Gershkovich, Emilio Perucca & Meir Bialer. (2020) The Interplay Between Liver First-Pass Effect and Lymphatic Absorption of Cannabidiol and Its Implications for Cannabidiol Oral Formulations. Clinical Pharmacokinetics 59:12, pages 1493-1500.
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Shashank Chaturvedi, Anuj Garg & Anurag Verma. (2020) Nano lipid based carriers for lymphatic voyage of anti-cancer drugs: An insight into the in-vitro, ex-vivo, in-situ and in-vivo study models. Journal of Drug Delivery Science and Technology 59, pages 101899.
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Nagarjun Rangaraj, Sravanthi Reddy Pailla, Saurabh Shah, Shubham Prajapati & Sunitha Sampathi. (2020) QbD aided development of ibrutinib-loaded nanostructured lipid carriers aimed for lymphatic targeting: evaluation using chylomicron flow blocking approach. Drug Delivery and Translational Research 10:5, pages 1476-1494.
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Nan Zhang, Fei Zhang, Shuo Xu, Kaiqing Yun, Wenjing Wu & Weisan Pan. (2020) Formulation and evaluation of luteolin supersaturatable self-nanoemulsifying drug delivery system (S-SNEDDS) for enhanced oral bioavailability. Journal of Drug Delivery Science and Technology 58, pages 101783.
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