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International Journal of Nanomedicine Volume 14, 2019 - Issue
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Original Research

Synthesis and characterization of a long-acting emtricitabine prodrug nanoformulation

Ibrahim M Ibrahim1 Department of Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical Center, Omaha, NE, USA;2 Department of Pharmacology, College of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia
,
Aditya N Bade1 Department of Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical Center, Omaha, NE, USA
,
Zhiyi Lin3 Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE, USA
,
Dhruvkumar Soni3 Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE, USA
,
Melinda Wojtkiewicz1 Department of Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical Center, Omaha, NE, USA
,
Bhagya Laxmi Dyavar Shetty1 Department of Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical Center, Omaha, NE, USA
,
Nagsen Gautam3 Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE, USA
,
JoEllyn M McMillan1 Department of Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical Center, Omaha, NE, USA
,
Yazen Alnouti3 Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE, USA
,
Benson J Edagwa1 Department of Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical Center, Omaha, NE, USA
&
Howard E Gendelman1 Department of Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical Center, Omaha, NE, USA;3 Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE, USACorrespondence[email protected] [email protected]
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Pages 6231-6247 | Published online: 07 Aug 2019

Citations (12)

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Denise A. Cobb, Nathan A. Smith, Benson J. Edagwa & JoEllyn M. McMillan. (2020) Long-acting approaches for delivery of antiretroviral drugs for prevention and treatment of HIV: a review of recent research. Expert Opinion on Drug Delivery 17:9, pages 1227-1238.
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Articles from other publishers (11)

Anil B. Jindal, Atharva R. Bhide, Sagar Salave, Dhwani Rana & Derajram Benival. (2023) Long-acting parenteral drug delivery systems for the treatment of chronic diseases. Advanced Drug Delivery Reviews 198, pages 114862.
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Franck Amblard, Dharmeshkumar Patel, Eleftherios Michailidis, Steven J. Coats, Mahesh Kasthuri, Nicolas Biteau, Zahira Tber, Maryam Ehteshami & Raymond F. Schinazi. (2022) HIV nucleoside reverse transcriptase inhibitors. European Journal of Medicinal Chemistry 240, pages 114554.
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Vicente Soriano, Benson Edagwa, Carmen de Mendoza, Pablo Barreiro, Octavio Corral, Ana Treviño & Howard E Gendelman. (2022) Ultra-long-acting antivirals as chemical vaccines to prevent viral diseases. Future Microbiology 17:11, pages 887-897.
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Raymond F Schinazi, Dharmeshkumar Patel & Maryam Ehteshami. (2022) The best backbone for HIV prevention, treatment, and elimination: Emtricitabine+tenofovir. Antiviral Therapy 27:2, pages 135965352110675.
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Milica Markovic, Suyash Deodhar, Jatin Machhi, Pravin Yeapuri, Maamoon Saleh, Benson J. Edagwa, Rodney Lee Mosley & Howard E. Gendelman. (2022) Prodrug Therapies for Infectious and Neurodegenerative Diseases. Pharmaceutics 14:3, pages 518.
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Dhanashree H Surve & Anil B. Jindal. (2021) Development of cationic Isometamidium chloride loaded long-acting lipid nanoformulation: optimization, cellular uptake, pharmacokinetics, biodistribution, and immunohistochemical evaluation. European Journal of Pharmaceutical Sciences 167, pages 106024.
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Naglaa Salem El-Sayed, Alexander S. Jureka, Megan R. Edwards, Sandeep Lohan, Caroline G. Williams, Patrick T. Keiser, Robert A. Davey, Jennifer Totonchy, Rakesh K. Tiwari, Christopher F. Basler & Keykavous Parang. (2021) Synthesis and antiviral activity of fatty acyl conjugates of remdesivir against severe acute respiratory syndrome coronavirus 2 and Ebola virus. European Journal of Medicinal Chemistry 226, pages 113862.
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Faiyaz Shakeel, Nazrul Haq, Ibrahim Alsarra & Sultan Alshehri. (2021) Solubility Data, Solubility Parameters and Thermodynamic Behavior of an Antiviral Drug Emtricitabine in Different Pure Solvents: Molecular Understanding of Solubility and Dissolution. Molecules 26:3, pages 746.
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Dhanashree H. Surve & Anil B. Jindal. (2020) Recent advances in long-acting nanoformulations for delivery of antiretroviral drugs. Journal of Controlled Release 324, pages 379-404.
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Faiyaz Shakeel, Nazrul Haq, Ibrahim A. Alsarra & Sultan Alshehri. (2020) Solubility, Hansen Solubility Parameters and Thermodynamic Behavior of Emtricitabine in Various (Polyethylene Glycol-400 + Water) Mixtures: Computational Modeling and Thermodynamics. Molecules 25:7, pages 1559.
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Mary G. Banoub, Aditya N. Bade, Zhiyi Lin, Denise Cobb, Nagsen Gautam, Bhagya Laxmi Dyavar Shetty, Melinda Wojtkiewicz, Yazen Alnouti, JoEllyn McMillan, Howard E. Gendelman & Benson Edagwa. (2019) Synthesis and Characterization of Long-Acting Darunavir Prodrugs. Molecular Pharmaceutics 17:1, pages 155-166.
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