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International Journal of Nanomedicine Volume 14, 2019 - Issue
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Original Research

Echogenic PEGylated PEI-Loaded Microbubble As Efficient Gene Delivery System

Chun Liufu1 Department of Ultrasound Medicine, Laboratory of Ultrasound Molecular Imaging, The Third Affiliated Hospital of Guangzhou Medical University, Experimental Center, The Liwan Hospital of The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong510000, People’s Republic of China
,
Yue Li1 Department of Ultrasound Medicine, Laboratory of Ultrasound Molecular Imaging, The Third Affiliated Hospital of Guangzhou Medical University, Experimental Center, The Liwan Hospital of The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong510000, People’s Republic of China
,
Jiawei Tu1 Department of Ultrasound Medicine, Laboratory of Ultrasound Molecular Imaging, The Third Affiliated Hospital of Guangzhou Medical University, Experimental Center, The Liwan Hospital of The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong510000, People’s Republic of China
,
Hui Zhang1 Department of Ultrasound Medicine, Laboratory of Ultrasound Molecular Imaging, The Third Affiliated Hospital of Guangzhou Medical University, Experimental Center, The Liwan Hospital of The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong510000, People’s Republic of China
,
Jinsui Yu1 Department of Ultrasound Medicine, Laboratory of Ultrasound Molecular Imaging, The Third Affiliated Hospital of Guangzhou Medical University, Experimental Center, The Liwan Hospital of The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong510000, People’s Republic of China
,
Yi Wang1 Department of Ultrasound Medicine, Laboratory of Ultrasound Molecular Imaging, The Third Affiliated Hospital of Guangzhou Medical University, Experimental Center, The Liwan Hospital of The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong510000, People’s Republic of China
,
Pintong Huang2 Department of Ultrasound, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, People’s Republic of China
&
Zhiyi Chen1 Department of Ultrasound Medicine, Laboratory of Ultrasound Molecular Imaging, The Third Affiliated Hospital of Guangzhou Medical University, Experimental Center, The Liwan Hospital of The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong510000, People’s Republic of ChinaCorrespondence[email protected]
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Pages 8923-8941 | Published online: 15 Nov 2019

Citations (13)

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Read on this site (2)

Yue Li, Meng Du, Jinghui Fang, Jia Zhou & Zhiyi Chen. (2021) UTMD promoted local delivery of miR-34a-mimic for ovarian cancer therapy. Drug Delivery 28:1, pages 1616-1625.
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Chun Liufu, Yue Li, Yan Lin, Jinsui Yu, Meng Du, Yuhao Chen, Yaozhang Yang, Xiaojing Gong & Zhiyi Chen. (2020) Synergistic ultrasonic biophysical effect-responsive nanoparticles for enhanced gene delivery to ovarian cancer stem cells. Drug Delivery 27:1, pages 1018-1033.
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Articles from other publishers (11)

Ruiqian Guo, Lei Wang, Jianbo Huang, Houqing Pang, Liyun Wang, Bihui Zhu, Yuanjiao Tang, Lang Ma & Li Qiu. (2023) Ultrasound-Targeted Microbubble Destruction-Mediated Cell-Mimetic Nanodrugs for Treating Rheumatoid Arthritis. ACS Biomaterials Science & Engineering 9:6, pages 3670-3679.
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Yu Wu, Cheng Deng, Jia Xu, Wei Wang, Yihan Chen, Xiaojuan Qin, Qing Lv & Mingxing Xie. (2023) Enhanced Local Delivery of microRNA-145a-5P into Mouse Aorta via Ultrasound-Targeted Microbubble Destruction Inhibits Atherosclerotic Plaque Formation. Molecular Pharmaceutics 20:2, pages 1086-1095.
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Godfred Amfo Agyekum, Min Zhang, Fei Li, Min Sun, Fengyun Zhang, Yu Yang, Yuan Lu, Minmin Chen & Zhuoqi Zhang. (2022) The complexing of cationic copolymer MPC 30 -DEA 70 with TGF-β1 antisense oligodeoxynucleotide and transfection into cardiomyocytes in vitro . Journal of Biomaterials Applications 37:7, pages 1315-1324.
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Yang Qin, Xiaorui Geng, Yue Sun, Yitong Zhao, Wenyu Chai, Xiaobing Wang & Pan Wang. (2023) Ultrasound nanotheranostics: Toward precision medicine. Journal of Controlled Release 353, pages 105-124.
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Rachel Chapla, Katherine T. Huynh & Carolyn E. Schutt. (2022) Microbubble–Nanoparticle Complexes for Ultrasound-Enhanced Cargo Delivery. Pharmaceutics 14:11, pages 2396.
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Valeria Graceffa. (2021) Physical and mechanical cues affecting biomaterial-mediated plasmid DNA delivery: insights into non-viral delivery systems. Journal of Genetic Engineering and Biotechnology 19:1.
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Chao Zhang, Shuyuan Chen, Qunying Li, Jiao Wu, Fuqiang Qiu, Zhiyi Chen, Yang Sun, Jieli Luo, Raul A. Bastarrachea, Paul A. Grayburn, Ralph A. DeFronzo, Yajing Liu, Kun Qian & Pintong Huang. (2021) Ultrasound‐Targeted Microbubble Destruction Mediates Gene Transfection for Beta‐Cell Regeneration and Glucose Regulation. Small 17:31, pages 2008177.
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Rajiv Sanwal, Kushal Joshi, Mihails Ditmans, Scott S. H. Tsai & Warren L. Lee. (2021) Ultrasound and Microbubbles for Targeted Drug Delivery to the Lung Endothelium in ARDS: Cellular Mechanisms and Therapeutic Opportunities. Biomedicines 9:7, pages 803.
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Suchandra Chowdhury & Shyamasree GhoshSuchandra Chowdhury & Shyamasree Ghosh. 2021. Stem Cells. Stem Cells 213 237 .
Takehito Sugasawa, Kai Aoki, Kouki Yanazawa & Kazuhiro Takekoshi. (2020) Detection of Multiple Transgene Fragments in a Mouse Model of Gene Doping Based on Plasmid Vector Using TaqMan-qPCR Assay. Genes 11:7, pages 750.
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Hui Zhang, Yue Li, Fang Rao, Chun Liufu, Yi Wang & Zhiyi Chen. (2020) A novel UTMD system facilitating nucleic acid delivery into MDA-MB-231 cells. Bioscience Reports 40:2.
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