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International Journal of Nanomedicine Volume 14, 2019 - Issue
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Original Research

Micelles Loaded With Puerarin And Modified With Triphenylphosphonium Cation Possess Mitochondrial Targeting And Demonstrate Enhanced Protective Effect Against Isoprenaline-Induced H9c2 Cells Apoptosis

Wen-qun Li1 Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha410011, People’s Republic of China;2 Institution of Clinical Pharmacy, Central South University, Changsha410011, People’s Republic of China;3 Hunan Provincial Engineering Research Center of Translational Medicine and Innovative Drugs, Changsha410011, People’s Republic of China
,
Jun-yong Wu1 Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha410011, People’s Republic of China;2 Institution of Clinical Pharmacy, Central South University, Changsha410011, People’s Republic of China;3 Hunan Provincial Engineering Research Center of Translational Medicine and Innovative Drugs, Changsha410011, People’s Republic of China
,
Da-xiong Xiang1 Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha410011, People’s Republic of China;2 Institution of Clinical Pharmacy, Central South University, Changsha410011, People’s Republic of China;3 Hunan Provincial Engineering Research Center of Translational Medicine and Innovative Drugs, Changsha410011, People’s Republic of China
,
Shi-lin Luo1 Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha410011, People’s Republic of China;2 Institution of Clinical Pharmacy, Central South University, Changsha410011, People’s Republic of China;3 Hunan Provincial Engineering Research Center of Translational Medicine and Innovative Drugs, Changsha410011, People’s Republic of China
,
Xiong-bin Hu1 Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha410011, People’s Republic of China;2 Institution of Clinical Pharmacy, Central South University, Changsha410011, People’s Republic of China;3 Hunan Provincial Engineering Research Center of Translational Medicine and Innovative Drugs, Changsha410011, People’s Republic of China
,
Tian-tian Tang1 Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha410011, People’s Republic of China;2 Institution of Clinical Pharmacy, Central South University, Changsha410011, People’s Republic of China;3 Hunan Provincial Engineering Research Center of Translational Medicine and Innovative Drugs, Changsha410011, People’s Republic of China
,
Tao-li Sun4 Key Laboratory Breeding Base of Hu’nan Oriented Fundamental and Applied Research of Innovative Pharmaceutics, College of Pharmacy, Changsha Medical University, Changsha410219, People’s Republic of China
&
Xin-yi Liu1 Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha410011, People’s Republic of China;2 Institution of Clinical Pharmacy, Central South University, Changsha410011, People’s Republic of China;3 Hunan Provincial Engineering Research Center of Translational Medicine and Innovative Drugs, Changsha410011, People’s Republic of ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-1725-6112
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Pages 8345-8360 | Published online: 21 Oct 2019

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YiFu Tian, CaiXia Zhou, XiaoYang Bu, Qian Lv & Qin Huang. (2023) Puerarin Attenuates High-Glucose and High-Lipid-Induced Inflammatory Injury in H9c2 Cardiomyocytes via CAV3 Protein Upregulation. Journal of Inflammation Research 16, pages 2707-2718.
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Fengmei Li, Yan Wang, Wenqun Li, Junyong Wu, Shengnan Li, Xiongbin Hu, Tiantian Tang & Xinyi Liu. (2023) Enhanced protection against hypoxia/reoxygenation-induced apoptosis in H9c2 cells by puerarin-loaded liposomes modified with matrix metalloproteinases-targeting peptide and triphenylphosphonium. Journal of Liposome Research 33:4, pages 378-391.
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Jieke Yan, Jing Guo, Yuzhen Wang, Xiaowei Xing, Xuguang Zhang, Guanghao Zhang & Zhaoqiang Dong. (2022) Acute myocardial infarction therapy using calycosin and tanshinone co-loaded; mitochondrion-targeted tetrapeptide and cyclic arginyl-glycyl-aspartic acid peptide co-modified lipid-polymer hybrid nano-system: preparation, characterization, and anti myocardial infarction activity assessment. Drug Delivery 29:1, pages 2815-2823.
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Mahvash Hesari, Pantea Mohammadi, Fatemeh Khademi, Dareuosh Shackebaei, Saeideh Momtaz, Narges Moasefi, Mohammad Hosein Farzaei & Mohammad Abdollahi. (2021) Current Advances in the Use of Nanophytomedicine Therapies for Human Cardiovascular Diseases. International Journal of Nanomedicine 16, pages 3293-3315.
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Di Wang, Tong Bu, Yangqian Li, Yueyue He, Fan Yang & Liang Zou. (2022) Pharmacological Activity, Pharmacokinetics, and Clinical Research Progress of Puerarin. Antioxidants 11:11, pages 2121.
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