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International Journal of Nanomedicine Volume 15, 2020 - Issue
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Original Research

Encapsulated n-Butylidenephthalide Efficiently Crosses the Blood–Brain Barrier and Suppresses Growth of Glioblastoma

Yu-Ling Lin1 Agricultural Biotechnology Research Center, Academia Sinica, Taipei 11529, Taiwan, Republic of China
,
Xiao-Fan Huang2 Department of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung 40201, Taiwan, Republic of China;3 Institute of Medicine of Chung Shun Medical University, Taichung 40201, Taiwan, Republic of China
,
Kai-Fu Chang2 Department of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung 40201, Taiwan, Republic of China;3 Institute of Medicine of Chung Shun Medical University, Taichung 40201, Taiwan, Republic of China
,
Kuang-Wen Liao4 Department of Biological Science and Technology, National Chiao Tung University, Hsinchu 30010, Taiwan, Republic of China;5 Institute of Molecular Medicine and Bioengineering, National Chiao Tung University, Hsinchu 30010, Taiwan, Republic of China;6 Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan, Republic of China
&
Nu-Man Tsai2 Department of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung 40201, Taiwan, Republic of China;7 Clinical Laboratory, Chung Shan Medical University Hospital, Taichung 40201, Taiwan, Republic of ChinaCorrespondence[email protected]
Pages 749-760 | Published online: 31 Jan 2020

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Suraj Sharma, Khadga Raj & Shamsher Singh. (2022) Protective effects of cerebrolysin against chemotherapy (carmustine) induced cognitive impairment in Albino mice. Drug and Chemical Toxicology 45:6, pages 2769-2779.
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Yumin Wu, Weifeng Shi, Honghai Wang, Jiawei Yue, Yijie Mao, Wei Zhou, Xinagmin Kong, Qiqiong Guo, Lirong Zhang, Pengxiao Xu & Yuyue Wang. (2020) Anti-ST2 Nanoparticle Alleviates Lung Inflammation by Targeting ILC2s-CD4+T Response. International Journal of Nanomedicine 15, pages 9745-9758.
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Articles from other publishers (10)

Susan S.C. Cheung, Djamel Khelifi, Zhuo-Shun Yang, David Hasman, Long-Jun Dai, Jin-Xin Xin, Bin Wang & Joseph Tai. (2023) Devil's club Falcarinol inhibits human glioblastoma cell proliferation and tumor progression in xenografts. Pharmacological Research - Modern Chinese Medicine 8, pages 100271.
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Shu‐Shong Hsu, Yung‐Shang Lin, Hui‐Ching Chen & Wei‐Zhe Liang. (2023) Involvement of oxidative stress‐related apoptosis in chlorpyrifos‐induced cytotoxicity and the ameliorating potential of the antioxidant vitamin E in human glioblastoma cells. Environmental Toxicology 38:9, pages 2143-2154.
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Ya-Chih Huang, Bo-Chun Chen, Kai-Fu Chang, Ming-Chang Hsieh, Gwo-Tarng Sheu, Chih-Yen Hsiao & Nu-Man Tsai. (2023) The alleviation effects of n-butylidenephthalide on apoptosis, senescence, and tight junction impairment of retinal pigment epithelium by activating Nrf-2/HO-1 signaling pathway in early diabetic retinopathy. Life Sciences 327, pages 121815.
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Chia-Hung Chen, Tzu-Han Weng, Hsiao-Hsuan Huang, Ling-Ya Huang, Kai-Yao Huang, Pin-Rong Chen, Kuang-Yu Yeh, Chi-Ting Huang, Yu-Tzu Chien, Po-Ya Chuang, Yu-Ling Lin, Nu-Man Tsai, Shih-Jen Liu, Yu-Cheng Su, Shun-Long Weng & Kuang-Wen Liao. (2023) A flexible liposomal polymer complex as a platform of specific and regulable immune regulation for individual cancer immunotherapy. Journal of Experimental & Clinical Cancer Research 42:1.
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Chia-Hung Chen, Tzu-Han Weng, Cheng-Hsun Chuang, Kai-Yao Huang, Sih-Cheng Huang, Pin-Rong Chen, Hsiao-Hsuan Huang, Ling-Ya Huang, Pei-Chun Shen, Po-Ya Chuang, Hsiao-Yen Huang, Yi-Syuan Wu, Hao-Chiun Chang, Shun-Long Weng & Kuang-Wen Liao. (2023) Transdermal nanolipoplex simultaneously inhibits subcutaneous melanoma growth and suppresses systemically metastatic melanoma by activating host immunity. Nanomedicine: Nanotechnology, Biology and Medicine 47, pages 102628.
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Wei Wuli, Shinn-Zong Lin, Shee-Ping Chen, Bakhos A. Tannous, Wen-Sheng Huang, Peng Yeong Woon, Yang-Chang Wu, Hsueh-Hui Yang, Yi-Cheng Chen, Renata Lopes Fleming, Jack T. Rogers, Catherine M. Cahill, Tsung-Jung Ho, Tzyy-Wen Chiou & Horng-Jyh Harn. (2022) Targeting PSEN1 by lnc-CYP3A43-2/miR-29b-2-5p to Reduce β Amyloid Plaque Formation and Improve Cognition Function. International Journal of Molecular Sciences 23:18, pages 10554.
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Ming-Tai Hsing, Hui-Ting Hsu, Chih-Hsuan Chang, Kai-Bo Chang, Chun-Yuan Cheng, Jae-Hwan Lee, Chien-Li Huang, Meng-Yin Yang, Yi-Chin Yang, Szu-Yuan Liu, Chun-Ming Yen, Shun-Fa Yang & Huey-Shan Hung. (2022) Improved Delivery Performance of n-Butylidenephthalide-Polyethylene Glycol-Gold Nanoparticles Efficient for Enhanced Anti-Cancer Activity in Brain Tumor. Cells 11:14, pages 2172.
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Hengyu Li, Hongwei Zhao, Yong Yang, Dongmei Qi, Xiaorui Cheng & Jiafeng Wang. (2021) Identification of Chemical Components of Qi-Fu-Yin and Its Prototype Components and Metabolites in Rat Plasma and Cerebrospinal Fluid via UPLC-Q-TOF-MS. Evidence-Based Complementary and Alternative Medicine 2021, pages 1-27.
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X.-F. Huang, P.-T. Chen, Y.-L. Lin, M.-S. Lee, K.-F. Chang, K.-W. Liao, G.-T. Sheu, M.-C. Hsieh & N.-M. Tsai. (2020) Enhanced anticancer activity and endocytic mechanisms by polymeric nanocarriers of n-butylidenephthalide in leukemia cells. Clinical and Translational Oncology 23:6, pages 1142-1151.
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Kai-Fu Chang, Jinghua Tsai Chang, Xiao-Fan Huang, Yu-Ling Lin, Kuang-Wen Liao, Chien-Wei Huang & Nu-Man Tsai. (2020) Antitumor Effects of N-Butylidenephthalide Encapsulated in Lipopolyplexs in Colorectal Cancer Cells. Molecules 25:10, pages 2394.
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