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International Journal of Nanomedicine Volume 15, 2020 - Issue
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Original Research

TiO2 Nanoparticles Caused DNA Damage in Lung and Extra-Pulmonary Organs Through ROS-Activated FOXO3a Signaling Pathway After Intratracheal Administration in Rats

Bin Han1 Department of Toxicology, Hebei Medical University, Shijiazhuang 050017, Hebei, People’s Republic of China
,
Zijie Pei2 Department of Pathology, Medical School, China Three Gorge University, Yichang 443002, People’s Republic of China
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Lei Shi3 Occupational Health and Environmental Health, Hebei Medical University, Shijiazhuang 050017, Hebei, People’s Republic of China
,
Qian Wang4 Experimental Center, Hebei Medical University, Shijiazhuang 050017, Hebei, People’s Republic of China
,
Chen Li1 Department of Toxicology, Hebei Medical University, Shijiazhuang 050017, Hebei, People’s Republic of China
,
Boyuan Zhang1 Department of Toxicology, Hebei Medical University, Shijiazhuang 050017, Hebei, People’s Republic of China
,
Xuan Su1 Department of Toxicology, Hebei Medical University, Shijiazhuang 050017, Hebei, People’s Republic of China
,
Ning Zhang1 Department of Toxicology, Hebei Medical University, Shijiazhuang 050017, Hebei, People’s Republic of China
,
Lixiao Zhou1 Department of Toxicology, Hebei Medical University, Shijiazhuang 050017, Hebei, People’s Republic of China
,
Bo Zhao5 Department of Laboratory Diagnosis, Hebei Medical University, Shijiazhuang 050017, Hebei, People’s Republic of China
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Yujie Niu3 Occupational Health and Environmental Health, Hebei Medical University, Shijiazhuang 050017, Hebei, People’s Republic of China;6 Hebei Key Laboratory of Environment and Human Health, Hebei Medical University, Shijiazhuang 050017, Hebei, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0001-7683-3242
ORCID Icon &
Rong Zhang1 Department of Toxicology, Hebei Medical University, Shijiazhuang 050017, Hebei, People’s Republic of China;6 Hebei Key Laboratory of Environment and Human Health, Hebei Medical University, Shijiazhuang 050017, Hebei, People’s Republic of ChinaCorrespondence[email protected]
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Pages 6279-6294 | Published online: 21 Aug 2020

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Julien Vignard, Aurelie Pettes-Duler, Eric Gaultier, Christel Cartier, Laurent Weingarten, Antje Biesemeier, Tatjana Taubitz, Philippe Pinton, Cecilia Bebeacua, Laurent Devoille, Jacques Dupuy, Elisa Boutet-Robinet, Nicolas Feltin, Isabelle P. Oswald, Fabrice H. Pierre, Bruno Lamas, Gladys Mirey & Eric Houdeau. (2023) Food-grade titanium dioxide translocates across the buccal mucosa in pigs and induces genotoxicity in an in vitro model of human oral epithelium. Nanotoxicology 17:4, pages 289-309.
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