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Original Research

Fabrication, appraisal, and transdermal permeation of sildenafil citrate-loaded nanostructured lipid carriers versus solid lipid nanoparticles

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Pages 3195-3205 | Published online: 06 Dec 2011

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Crossref
Ragwa M. Farid, Noha S. El-Salamouni, Amal H. El-Kamel & Safaa S. El-Gamal. 2017. Nanostructures for Drug Delivery. Nanostructures for Drug Delivery 495 522 .
Lavin Aliasgharlou, Saeed Ghanbarzadeh, Hamideh Azimi, Mohammad Hossein Zarrintan & Hamed Hamishehkar. (2016) Nanostructured Lipid Carrier for Topical Application of N-Acetyl Glucosamine. Advanced Pharmaceutical Bulletin 6:4, pages 581-587.
Crossref
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Crossref
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Crossref
Melike Üner. 2016. Handbook of Nanoparticles. Handbook of Nanoparticles 117 141 .
Teng Guo, Yongtai Zhang, Jihui Zhao, Chunyun Zhu & Nianping Feng. (2015) Nanostructured lipid carriers for percutaneous administration of alkaloids isolated from Aconitum sinomontanum. Journal of Nanobiotechnology 13:1.
Crossref
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Crossref
Melike Üner. 2015. Handbook of Nanoparticles. Handbook of Nanoparticles 1 20 .
Manal A. Elsheikh, Yosra S.R. Elnaggar & Ossama Y. Abdallah. (2014) Rationale employment of cell culture versus conventional techniques in pharmaceutical appraisal of nanocarriers. Journal of Controlled Release 194, pages 92-102.
Crossref
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Crossref
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Crossref
Yosra S.R. Elnaggar, Wessam M. El-Refaie, Magda A. El-Massik & Ossama Y. Abdallah. (2014) Lecithin-based nanostructured gels for skin delivery: An update on state of art and recent applications. Journal of Controlled Release 180, pages 10-24.
Crossref
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Crossref
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Crossref
Nirupama Sabnis & Andras G Lacko. (2012) Drug delivery via lipoprotein-based carriers: answering the challenges in systemic therapeutics. Therapeutic Delivery 3:5, pages 599-608.
Crossref