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Original Research

Hydrophobic ion pairing of an insulin-sodium deoxycholate complex for oral delivery of insulin

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Pages 3049-3056 | Published online: 28 Nov 2011

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (17)

Yoon Tae Goo, Sangkil Lee, Ji Yeh Choi, Min Song Kim, Gi Hyeong Sin, Sun Ho Hong, Chang Hyun Kim, Seh Hyon Song & Young Wook Choi. (2022) Enhanced oral absorption of insulin: hydrophobic ion pairing and a self-microemulsifying drug delivery system using a D-optimal mixture design. Drug Delivery 29:1, pages 2831-2845.
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Santosh Bashyal, Jo-Eun Seo, Taekwang Keum, Gyubin Noh, Shrawani Lamichhane, Jeong Hwan Kim, Chang Hyun Kim, Young Wook Choi & Sangkil Lee. (2021) Facilitated Buccal Insulin Delivery via Hydrophobic Ion-Pairing Approach: In vitro and ex vivo Evaluation. International Journal of Nanomedicine 16, pages 4677-4691.
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Yasmeen Ezzeldeen, Shady Swidan, Aliaa ElMeshad & Aya Sebak. (2021) Green Synthesized Honokiol Transfersomes Relieve the Immunosuppressive and Stem-Like Cell Characteristics of the Aggressive B16F10 Melanoma. International Journal of Nanomedicine 16, pages 5693-5712.
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Chun Y. Wong, Hani Al-Salami & Crispin R. Dass. (2021) Fabrication techniques for the preparation of orally administered insulin nanoparticles. Journal of Drug Targeting 29:4, pages 365-386.
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Chun Y. Wong, Hani Al-Salami & Crispin R. Dass. (2020) Current status and applications of animal models in pre-clinical development of orally administered insulin-loaded nanoparticles. Journal of Drug Targeting 28:9, pages 882-903.
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Shiming He, Zhongcheng Liu & Donggang Xu. (2019) Advance in oral delivery systems for therapeutic protein. Journal of Drug Targeting 27:3, pages 283-291.
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Xiaomei Wang, Dan Cheng, Linglin Liu & Xuejun Li. (2018) Development of poly(hydroxyethyl methacrylate) nanogel for effective oral insulin delivery. Pharmaceutical Development and Technology 23:4, pages 351-357.
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Mohamed A. Safwat, Ghareb M. Soliman, Douaa Sayed & Mohamed A. Attia. (2017) Gold nanoparticles capped with benzalkonium chloride and poly (ethylene imine) for enhanced loading and skin permeability of 5-fluorouracil. Drug Development and Industrial Pharmacy 43:11, pages 1780-1791.
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Mariana Silva Oliveira, Gisele Castro Assis Goulart, Lucas Antônio Miranda Ferreira & Guilherme Carneiro. (2017) Hydrophobic ion pairing as a strategy to improve drug encapsulation into lipid nanocarriers for the cancer treatment. Expert Opinion on Drug Delivery 14:8, pages 983-995.
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Vivek S. Dave, Deepak Gupta, Monica Yu, Phuong Nguyen & Sheeba Varghese Gupta. (2017) Current and evolving approaches for improving the oral permeability of BCS Class III or analogous molecules. Drug Development and Industrial Pharmacy 43:2, pages 177-189.
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Shaoping Sun, Na Liang, Hiromitsu Yamamoto, Yoshiaki Kawashima, Fude Cui & Pengfei Yan. (2015) pH-sensitive poly(lactide-co-glycolide) nanoparticle composite microcapsules for oral delivery of insulin. International Journal of Nanomedicine 10, pages 3489-3498.
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Sampath Malathi, Perumal Nandhakumar, Velayudham Pandiyan, Thomas J Webster & Sengottuvelan Balasubramanian. (2015) Novel PLGA-based nanoparticles for the oral delivery of insulin. International Journal of Nanomedicine 10, pages 2207-2218.
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Seung Rim Hwang, In Jae Kim & Jin Woo Park. (2015) Formulations of deoxycholic for therapy: a patent review (2011 – 2014). Expert Opinion on Therapeutic Patents 25:12, pages 1423-1440.
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Gintare Leonaviciute & Andreas Bernkop-Schnürch. (2015) Self-emulsifying drug delivery systems in oral (poly)peptide drug delivery. Expert Opinion on Drug Delivery 12:11, pages 1703-1716.
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Ashaben Patel, Ripal Gaudana & Ashim K. Mitra. (2014) A novel approach for antibody nanocarriers development through hydrophobic ion-pairing complexation. Journal of Microencapsulation 31:6, pages 542-550.
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Seung Woo Chung, Taslim A. Hil-lal & Youngro Byun. (2012) Strategies for non-invasive delivery of biologics. Journal of Drug Targeting 20:6, pages 481-501.
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Sara I. Abd-El Hafeez, Nermin E. Eleraky, Ehsan Hafez & Sara A. Abouelmagd. (2022) Design and optimization of metformin hydrophobic ion pairs for efficient encapsulation in polymeric drug carriers. Scientific Reports 12:1.
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Stephanie Fuchs, Alexander U. Ernst, Long-Hai Wang, Kaavian Shariati, Xi Wang, Qingsheng Liu & Minglin Ma. (2020) Hydrogels in Emerging Technologies for Type 1 Diabetes. Chemical Reviews 121:18, pages 11458-11526.
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Sweet Naskar, Sanjoy Kumar Das, Suraj Sharma & Ketousetuo Kuotsu. (2021) A Review on Designing Poly (Lactic-co-glycolic Acid) Nanoparticles as Drug Delivery Systems. Pharmaceutical Nanotechnology 9:1, pages 36-50.
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Markus Kurpiers, Julian Dominik Wolf, Helen Spleis, Christian Steinbring, Arne Matteo Jörgensen, Barbara Matuszczak & Andreas Bernkop-Schnürch. (2021) Lysine-Based Biodegradable Surfactants: Increasing the Lipophilicity of Insulin by Hydrophobic Ion Paring. Journal of Pharmaceutical Sciences 110:1, pages 124-134.
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Fatemeh Dadgar Pakdel, Ahmad MirshahiPayam ZahediKazem MohammadFarkhondeh HemmatiJavad Dadgar PakdelMohammad Hossein Nicknam & Farid Abedin Dorkoosh. (2020) A Novel Approach for Development of Intraocular Biodegradable Ranibizumab Implant: A Solution for Stability of Protein Activity. Advanced Pharmaceutical Bulletin 11:4, pages 632-642.
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Abu Hajleh Maha & Al-Dujaili Emad A.S. (2020) HYDROPHOBIC ION-PAIRED DRUG DELIVERY SYSTEM: A REVIEW. INDIAN DRUGS 57:01, pages 7-18.
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Kuldeep Rajpoot, Muktika Tekade, Mukesh Chandra Sharma, Nagashekhara Molugulu & Rakesh K. Tekade. 2020. The Future of Pharmaceutical Product Development and Research. The Future of Pharmaceutical Product Development and Research 483 514 .
Seungju Seo, Il Jeon, Rong Xiang, Changsoo Lee, Hao Zhang, Takeshi Tanaka, Jin-Wook Lee, Donguk Suh, Tatsuro Ogamoto, Ryosuke Nishikubo, Akinori Saeki, Shohei Chiashi, Junichiro Shiomi, Hiromichi Kataura, Hyuck Mo Lee, Yang Yang, Yutaka Matsuo & Shigeo Maruyama. (2019) Semiconducting carbon nanotubes as crystal growth templates and grain bridges in perovskite solar cells. Journal of Materials Chemistry A 7:21, pages 12987-12992.
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Sam Maher, David Brayden, Luca Casettari & Lisbeth Illum. (2019) Application of Permeation Enhancers in Oral Delivery of Macromolecules: An Update. Pharmaceutics 11:1, pages 41.
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Zoë Folchman-Wagner, Jennica Zaro & Wei-Chiang Shen. (2017) Characterization of Polyelectrolyte Complex Formation Between Anionic and Cationic Poly(amino acids) and Their Potential Applications in pH-Dependent Drug Delivery. Molecules 22:7, pages 1089.
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