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Original Research

Anti-tumor effects of brucine immuno-nanoparticles on hepatocellular carcinoma

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Pages 369-379 | Published online: 23 Jan 2012

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Heba S. Elsewedy, Bandar E. Al Dhubiab, Mahmoud A. Mahdy & Hanan M. Elnahas. (2020) Development, optimization, and evaluation of PEGylated brucine-loaded PLGA nanoparticles. Drug Delivery 27:1, pages 1134-1146.
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Uma Saminathan, Pachaiappan Pugalendhi, Suganthi Subramaniyan & Rajendran Jayaganesh. (2019) Biochemical studies evaluating the chemopreventive potential of brucine in chemically induced mammary carcinogenesis of rats. Toxicology Mechanisms and Methods 29:1, pages 8-17.
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Jun Chen, Chao-Qin He, Ai-Hua Lin, Fei Xu, Fang Wang, Bo Zhao, Xiao Liu, Zhi-Peng Chen & Bao-chang Cai. (2014) Brucine-loaded liposomes composed of HSPC and DPPC at different ratios: in vitro and in vivo evaluation. Drug Development and Industrial Pharmacy 40:2, pages 244-251.
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Articles from other publishers (27)

Reena Gupta, Mustafa M. Kadhim, Abduladheem Turki Jalil, Ali Mohammed Obayes, Zafar Aminov, Fahad Alsaikhan, Andrés Alexis Ramírez-Coronel, Pushpamala Ramaiah, Nahla A. Tayyib & Xuanming Luo. (2023) Multifaceted role of NF-κB in hepatocellular carcinoma therapy: Molecular landscape, therapeutic compounds and nanomaterial approaches. Environmental Research 228, pages 115767.
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Chun-Tse Wang & Bor-Sen Chen. (2023) Drug Discovery for Periodontitis Treatment Based on Big Data Mining, Systems Biology, and Deep Learning Methods. SynBio 1:1, pages 116-143.
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Semira Biya, Negussie Negash, Tesfu Hailu, Gizaw Tesfaye & Estifanose Ele Yaya. (2023) Highly sensitive square wave voltammetric method for determination of brucine in artificial urine samples based on choline chloride modified glassy carbon electrode. Heliyon 9:3, pages e14544.
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Yan Gao, Lin Guo, Ying Han, Jingpu Zhang, Zhong Dai & Shuangcheng Ma. (2023) A Combination of In Silico ADMET Prediction, In Vivo Toxicity Evaluation, and Potential Mechanism Exploration of Brucine and Brucine N-oxide—A Comparative Study. Molecules 28:3, pages 1341.
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Muhammad Noman, Neelum Gul Qazi, Najeeb Ur Rehman & Arif-ullah Khan. (2022) Pharmacological investigation of brucine anti-ulcer potential. Frontiers in Pharmacology 13.
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Liang Zhang & Wenying Yu. (2021) Pharmacological Effects, Pharmacokinetics, and Strategies to Reduce Brucine Toxicity. Revista Brasileira de Farmacognosia 32:1, pages 39-49.
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Anita Bakrania, Gang Zheng & Mamatha Bhat. (2021) Nanomedicine in Hepatocellular Carcinoma: A New Frontier in Targeted Cancer Treatment. Pharmaceutics 14:1, pages 41.
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Keenan J. Mintz & Roger M. Leblanc. (2021) The use of nanotechnology to combat liver cancer: Progress and perspectives. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1876:2, pages 188621.
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Jixian Zhang, Ping Zhan & Honglei Tian. (2021) Recent updates in the polysaccharides-based Nano-biocarriers for drugs delivery and its application in diseases treatment: A review. International Journal of Biological Macromolecules 182, pages 115-128.
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Nabil A. Alhakamy, Hibah M. Aldawsari, Javed Ali, Dipak K. Gupta, Musarrat H. Warsi, Anwar L. Bilgrami, Hani Z. Asfour, Ahmad O. Noor & Shadab Md. (2021) Brucine-loaded transliposomes nanogel for topical delivery in skin cancer: statistical optimization, in vitro and dermatokinetic evaluation. 3 Biotech 11:6.
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Shuang Cai, Yanping Shi, Jifeng Tian, Xia Li & Hui Ji. (2021) Salutary effect of brucine in ovalbumin-induced allergic rhinitis: Role of t-helper 1, t-helper 2 cytokines, nuclear factor-kappa b, stat3, and rorc signaling in mouse models. Pharmacognosy Magazine 17:76, pages 900.
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Heba S. Elsewedy, Bandar E. Aldhubiab, Mahmoud A. Mahdy & Hanan M. Elnahas. (2021) Brucine PEGylated nanoemulsion: In vitro and in vivo evaluation. Colloids and Surfaces A: Physicochemical and Engineering Aspects 608, pages 125618.
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Lu Lu, Rui Huang, Ye Wu, Jin-Mei Jin, Hong-Zhuan Chen, Li-Jun Zhang & Xin Luan. (2020) Brucine: A Review of Phytochemistry, Pharmacology, and Toxicology. Frontiers in Pharmacology 11.
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Chandrashekar Mudithanapelli & Mi-hyun Kim. (2020) Metal-free late-stage C(sp 2 )–H functionalization of N -aryl amines with various sodium salts . Organic & Biomolecular Chemistry 18:3, pages 450-464.
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Wan Nie, Baolin Zhang, Ru Pan, Sheng Wang, Xianjia Yan & Jie Tan. (2019) Surface Modification with Chondroitin Sulfate Targets Nanoparticles to the Neuronal Cell Membrane in the Substantia Nigra. ACS Chemical Neuroscience 11:2, pages 197-204.
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Aboothahir Afzal, Mohamed Shahin Thayyil, Mohammad Shariq, Yohannan Sheena Mary, Kaippallil Sundaresan Resmi, Renjith Thomas, Nasarul Islam & Ajithan Jyothi Abinu. (2019) Anti‐Cancerous Brucine and Colchicine: Experimental and Theoretical Characterization. ChemistrySelect 4:39, pages 11441-11454.
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Zhe Ma, Bing Zhang, Yuqi Fan, Meng Wang, Dereje Kebebe, Jiawei Li & Zhidong Liu. (2019) Traditional Chinese medicine combined with hepatic targeted drug delivery systems: A new strategy for the treatment of liver diseases. Biomedicine & Pharmacotherapy 117, pages 109128.
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Min Tang, Wei‑Ji Zhu, Zu‑Cheng Yang & Cheng‑Song He. (2019) Brucine inhibits TNF‑α‑induced HFLS‑RA cell proliferation by activating the JNK signaling pathway. Experimental and Therapeutic Medicine.
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Aboothahir Afzal, M. Shahin Thayyil, P.A. Sivaramakrishnan, M.K. Sulaiman, K.P. Safna Hussan, C. Yohannan Panicker & K.L. Ngai. (2019) Dielectric spectroscopic studies in supercooled liquid and glassy states of Acemetacin, Brucine and Colchicine. Journal of Non-Crystalline Solids 508, pages 33-45.
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Aboothahir Afzal, M. Shahin Thayyil, M. K. Sulaiman & A. R. Kulkarni. (2017) Dielectric relaxation studies in super-cooled liquid and glassy phases of anti-cancerous alkaloid: Brucine. Indian Journal of Physics 92:5, pages 565-573.
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Jianmin Qin, Lin Yang, Xia Sheng, Zhongqiu Sa, Tao Huang, Qi Li, Kepan Gao, Qinghua Chen, Jingwei Ma & Hebai Shen. (2018) Antitumor effects of brucine immuno-nanoparticles on hepatocellular carcinoma in�vivo. Oncology Letters.
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Miao Li, Ping Li, Mei Zhang & Feng Ma. (2017) Brucine suppresses breast cancer metastasis via inhibiting epithelial mesenchymal transition and matrix metalloproteinases expressions. Chinese Journal of Integrative Medicine 24:1, pages 40-46.
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Mei Lin, Junxing Huang, Dongsheng Zhang, Xingmao Jiang, Jia Zhang, Hong Yu, Yanhong Xiao, Yujuan Shi & Ting Guo. (2016) Hepatoma-Targeted Radionuclide Immune Albumin Nanospheres: 131 I-antiAFPMcAb-GCV-BSA-NPs . Analytical Cellular Pathology 2016, pages 1-8.
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Sang Joon Lee, Yong-Ho Shim, Jong-Suk Oh, Young-Il Jeong, In-Kyu Park & Hyun Chul Lee. (2015) Folic-acid-conjugated pullulan/poly(DL-lactide-co-glycolide) graft copolymer nanoparticles for folate-receptor-mediated drug delivery. Nanoscale Research Letters 10:1.
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Shouye Zhao, Peng Liu, Xinyuan Wen & Song Jin. (2015) RETRACTED ARTICLE: GelsemiumElegansBenth alkaloids extract induced cell cycle arrest resulting in anti-proliferation and pro-apoptosis effects on SMMC-7721 cells in vitro and in vivo. Molecular Biology Reports 42:8, pages 1351-1351.
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Sarita Saraswati, Abdulqader A. Alhaider & S.S. Agrawal. (2013) Anticarcinogenic effect of brucine in diethylnitrosamine initiated and phenobarbital-promoted hepatocarcinogenesis in rats. Chemico-Biological Interactions 206:2, pages 214-221.
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JIUN-LONG YANG, JU-HWA LIN, SHU-WEN WENG, JAW-CHYUN CHEN, JAI-SING YANG, SAKAE AMAGAYA, SHINJI FUNAYANA, W. GIBSON WOOD, CHAO-LIN KUO & JING-GUNG CHUNG. (2013) Crude extract of Euphorbia formosana inhibits the migration and invasion of DU145 human prostate cancer cells: The role of matrix metalloproteinase-2/9 inhibition via the MAPK signaling pathway. Molecular Medicine Reports 7:5, pages 1403-1408.
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