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International Journal of Nanomedicine Volume 16, 2021 - Issue
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Original Research

Clinical, Biochemical and Molecular Evaluations of Ivermectin Mucoadhesive Nanosuspension Nasal Spray in Reducing Upper Respiratory Symptoms of Mild COVID-19

Zaki F Aref1 ENT Department, Faculty of Medicine, South Valley University, Qena, EgyptORCID Iconhttps://orcid.org/0000-0002-1803-735XView further author information
ORCID Icon,
Shamardan Ezz Eldin S Bazeed2 Tropical Medicine and Gastroenterology Department, Faculty of Medicine, South Valley University, Qena, EgyptORCID Iconhttps://orcid.org/0000-0001-7653-0006View further author information
ORCID Icon,
Mohammed H Hassan3 Department of Medical Biochemistry, Faculty of Medicine, South Valley University, Qena, EgyptCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-2698-9438View further author information
ORCID Icon,
Abeer S Hassan4 Department of Pharmaceutics, Faculty of Pharmacy, South Valley University, Qena, EgyptORCID Iconhttps://orcid.org/0000-0001-8984-2957View further author information
ORCID Icon,
Alaa Rashad5 Department of Chest Diseases and Tuberculosis, Faculty of Medicine, South Vally University, Qena, EgyptView further author information
,
Rehab G Hassan6 Department of Public Health and Community Medicine, Faculty of Medicine, South Valley University, Qena, EgyptView further author information
&
Aida A Abdelmaksoud1 ENT Department, Faculty of Medicine, South Valley University, Qena, EgyptView further author information
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Pages 4063-4072 | Published online: 15 Jun 2021

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Fabio Sonvico, Gaia Colombo, Eride Quarta, Fabiola Guareschi, Sabrina Banella, Francesca Buttini & Regina Scherließ. (2023) Nasal delivery as a strategy for the prevention and treatment of COVID-19. Expert Opinion on Drug Delivery 20:8, pages 1115-1130.
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Zaki F Aref, Shamardan Ezz Eldin S Bazeed, Mohammed H Hassan, Abeer S Hassan, Ali A Ghweil, Mennatallah Ali Abdelrhman Sayed, Alaa Rashad, Haggagy Mansour & Aida A Abdelmaksoud. (2022) Possible Role of Ivermectin Mucoadhesive Nanosuspension Nasal Spray in Recovery of Post-COVID-19 Anosmia. Infection and Drug Resistance 15, pages 5483-5494.
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Maiara Callegaro Velho, Diego Fontana de Andrade & Ruy Carlos Ruver Beck. (2022) Ivermectin: recent approaches in the design of novel veterinary and human medicines. Pharmaceutical Development and Technology 27:8, pages 865-880.
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Eun A Kim, Jun Soo Park, Min Seop Kim, Min Young Jeong, Hyun Jin Park, Jun Hyuk Choi, Jae Hee Seo, Yong Seok Choi & Myung Joo Kang. (2021) High-Payload Nanosuspension of Centella asiatica Extract for Improved Skin Delivery with No Irritation. International Journal of Nanomedicine 16, pages 7417-7432.
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Articles from other publishers (21)

Vivek P. Chavda, Kajal P. Baviskar, Dixa A. Vaghela, Shilpa S. Raut & Anjali P. Bedse. (2023) Nasal sprays for treating COVID-19: a scientific note. Pharmacological Reports 75:2, pages 249-265.
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Tayo Alex Adekiya, Mumuni Sumaila, Raphael Taiwo Aruleba & Yahya E. Choonara. 2023. Viral Drug Delivery Systems. Viral Drug Delivery Systems 91 117 .
Majdy Idrees, Bridget McGowan, Amr Fawzy, Abdulwahab Ali Abuderman, Ramesh Balasubramaniam & Omar Kujan. (2022) Efficacy of Mouth Rinses and Nasal Spray in the Inactivation of SARS-CoV-2: A Systematic Review and Meta-Analysis of In Vitro and In Vivo Studies. International Journal of Environmental Research and Public Health 19:19, pages 12148.
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Hoda Awad, Basmala Hassan, Sara Dweek, Yasmeen Aboelata, Mutasem Rawas-Qalaji & Iman Saad Ahmed. (2022) Repurposing Potential of the Antiparasitic Agent Ivermectin for the Treatment and/or Prophylaxis of COVID-19. Pharmaceuticals 15:9, pages 1068.
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Samuel A. Stetkevich, Madison J. Anzelc & Craig G. Burkhart. (2022) Intranasal Ivermectin Spray, the Sunscreen to COVID-19. The Open Dermatology Journal 16:1.
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Sabine Hazan. (2022) Microbiome-Based Hypothesis on Ivermectin’s Mechanism in COVID-19: Ivermectin Feeds Bifidobacteria to Boost Immunity. Frontiers in Microbiology 13.
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Estefanía Calvo-Alvarez, Maria Dolci, Federica Perego, Lucia Signorini, Silvia Parapini, Sarah D’Alessandro, Luca Denti, Nicoletta Basilico, Donatella Taramelli, Pasquale Ferrante & Serena Delbue. (2022) Antiparasitic Drugs against SARS-CoV-2: A Comprehensive Literature Survey. Microorganisms 10:7, pages 1284.
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Shuangshuang Yang, Shan Shen & Ning Hou. (2022) Is Ivermectin Effective in Treating COVID-19?. Frontiers in Pharmacology 13.
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Maria Popp, Stefanie Reis, Selina Schießer, Renate Ilona Hausinger, Miriam Stegemann, Maria-Inti Metzendorf, Peter Kranke, Patrick Meybohm, Nicole Skoetz & Stephanie Weibel. (2022) Ivermectin for preventing and treating COVID-19. Cochrane Database of Systematic Reviews 2022:6.
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Laura Nižić Nodilo, Mirna Perkušić, Ivo Ugrina, Drago Špoljarić, Cvijeta Jakobušić Brala, Daniela Amidžić Klarić, Jasmina Lovrić, Vesna Saršon, Maša Safundžić Kučuk, Dijana Zadravec, Livije Kalogjera, Ivan Pepić & Anita Hafner. (2022) In situ gelling nanosuspension as an advanced platform for fluticasone propionate nasal delivery. European Journal of Pharmaceutics and Biopharmaceutics 175, pages 27-42.
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Eleonore Fröhlich. (2022) Non-Cellular Layers of the Respiratory Tract: Protection against Pathogens and Target for Drug Delivery. Pharmaceutics 14:5, pages 992.
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Mary B. McGuckin, Jiawen Wang, Rand Ghanma, Nuoya Qin, Santiago D. Palma, Ryan F. Donnelly & Alejandro J. Paredes. (2022) Nanocrystals as a master key to deliver hydrophobic drugs via multiple administration routes. Journal of Controlled Release 345, pages 334-353.
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Jeffrey Watchorn, Aaron J. Clasky, Gayatri Prakash, Ian A. E. Johnston, Paul Z. Chen & Frank X. Gu. (2022) Untangling Mucosal Drug Delivery: Engineering, Designing, and Testing Nanoparticles to Overcome the Mucus Barrier. ACS Biomaterials Science & Engineering 8:4, pages 1396-1426.
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Elide Zingale, Angela Bonaccorso, Claudia Carbone, Teresa Musumeci & Rosario Pignatello. (2022) Drug Nanocrystals: Focus on Brain Delivery from Therapeutic to Diagnostic Applications. Pharmaceutics 14:4, pages 691.
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Takahiro Itaya, Yotsuha Isobe, Sayoko Suzuki, Kanako Koike, Masakazu Nishigaki & Yosuke Yamamoto. (2022) The Fragility of Statistically Significant Results in Randomized Clinical Trials for COVID-19. JAMA Network Open 5:3, pages e222973.
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Fanny Salasc, Thomas Lahlali, Emilie Laurent, Manuel Rosa-Calatrava & Andrés Pizzorno. (2022) Treatments for COVID-19: Lessons from 2020 and new therapeutic options. Current Opinion in Pharmacology 62, pages 43-59.
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Nirmeen Sabry, Yasser Fouad, Mohamed AbdAllah, Ahmed Cordie & Gamal Esmat. (2022) Dose-Dependent Ivermectin Effect on COVID-19 Polymerase Chain Reaction Status. American Journal of Therapeutics Publish Ahead of Print.
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Pooria Asili, Maryam Mirahmad, Ozra Tabatabaei-Malazy, Azadeh Manayi, Elahe Haghighat, Mohammad Mahdavi & Bagher Larijani. (2021) Characteristics of published/registered clinical trials on COVID-19 treatment: A systematic review. DARU Journal of Pharmaceutical Sciences 29:2, pages 449-467.
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William H. Catherino. (2021) From the Editor-in-Chief. F&S Science 2:4, pages 315.
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Bissera Pilicheva & Radka Boyuklieva. (2021) Can the Nasal Cavity Help Tackle COVID-19?. Pharmaceutics 13:10, pages 1612.
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Chenyang Zhang, Huaqing Jin, Yi Feng Wen & Guosheng Yin. (2021) Efficacy of COVID-19 Treatments: A Bayesian Network Meta-Analysis of Randomized Controlled Trials. Frontiers in Public Health 9.
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