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International Journal of Nanomedicine Volume 7, 2012 - Issue
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Original Research

Bioconjugation of recombinant tissue plasminogen activator to magnetic nanocarriers for targeted thrombolysis

Hung-Wei Yang1 Chang Gung Molecular Medicine Research Center, Department of Chemical and Materials Engineering, Chang Gung Memorial Hospital, Kuei-Shan, Tao-Yuan, Taiwan, Republic of China
,
Mu-Yi Hua1 Chang Gung Molecular Medicine Research Center, Department of Chemical and Materials Engineering, Chang Gung Memorial Hospital, Kuei-Shan, Tao-Yuan, Taiwan, Republic of China
,
Kun-Ju Lin2 Molecular Imaging Center, Department of Nuclear Medicine, Chang Gung Memorial Hospital, Kuei-Shan, Tao-Yuan, Taiwan, Republic of China
,
Shiaw-Pyng Wey3 Department of Medical Imaging and Radiological Sciences, Industrial Technology Research Institute, Hsin-chu, Taiwan, Republic of China
,
Rung-Ywan Tsai4 Electronics and Optoelectronics Research Laboratories, Industrial Technology Research Institute, Hsin-chu, Taiwan, Republic of China
,
Siao-Yun Wu5 Department of Physiology and Pharmacology and Healthy Aging Research Center, Chang Gung University, Kuei-Shan, Tao-Yuan, Taiwan, Republic of China
,
Yi-Ching Lu5 Department of Physiology and Pharmacology and Healthy Aging Research Center, Chang Gung University, Kuei-Shan, Tao-Yuan, Taiwan, Republic of China
,
Hao-Li Liu6 Department of Electrical Engineering, Chang Gung University, Kuei-Shan, Tao-Yuan, Taiwan, Republic of China
,
Tony Wu7 Department of Neurology, Chang Gung University College of Medicine and Memorial Hospital, Tao-Yuan, Taiwan, Republic of ChinaCorrespondence[email protected] [email protected]
&
Yunn-Hwa Ma5 Department of Physiology and Pharmacology and Healthy Aging Research Center, Chang Gung University, Kuei-Shan, Tao-Yuan, Taiwan, Republic of ChinaCorrespondence[email protected] [email protected]
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Pages 5159-5173 | Published online: 01 Oct 2012

Citations (12)

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Read on this site (6)

Hongyin Ma, Zhenmin Jiang, Jiayun Xu, Junqiu Liu & Zhen-Ni Guo. (2021) Targeted nano-delivery strategies for facilitating thrombolysis treatment in ischemic stroke. Drug Delivery 28:1, pages 357-371.
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Sebastian P Pernal, Alexander J Willis, Michael E Sabo, Laura M Moore, Steven T Olson, Sean C Morris, Francis M Creighton & Herbert H Engelhard. (2020) An in vitro Model System for Evaluating Remote Magnetic Nanoparticle Movement and Fibrinolysis. International Journal of Nanomedicine 15, pages 1549-1568.
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Chien-Yu Chiu, Tze-Wen Chung, Si-Yi Chen & Yunn-Hwa Ma. (2019) Effects of PEGylation on capture of dextran-coated magnetic nanoparticles in microcirculation. International Journal of Nanomedicine 14, pages 4767-4780.
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Jie Liao, Xiaoting Ren, Bowen Yang, Hou Li, Yuexin Zhang & Zongning Yin. (2019) Targeted thrombolysis by using c-RGD-modified N,N,N-Trimethyl Chitosan nanoparticles loaded with lumbrokinase. Drug Development and Industrial Pharmacy 45:1, pages 88-95.
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Masumeh Zamanlu, Mehdi Farhoudi, Morteza Eskandani, Javad Mahmoudi, Jaleh Barar, Mohammad Rafi & Yadollah Omidi. (2018) Recent advances in targeted delivery of tissue plasminogen activator for enhanced thrombolysis in ischaemic stroke. Journal of Drug Targeting 26:2, pages 95-109.
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Shan Liu, Xiaozhou Feng, Rong Jin & Guohong Li. (2018) Tissue plasminogen activator-based nanothrombolysis for ischemic stroke. Expert Opinion on Drug Delivery 15:2, pages 173-184.
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Articles from other publishers (6)

Bohua Zhang, Huaiyu Wu & Xiaoning Jiang. (2022) Ultrasound and Magnetic Dual-Mode Stacked Transducer for Sonothrombolysis with a Combination of Nanodroplets and Magnetic Nanoparticles. Ultrasound and Magnetic Dual-Mode Stacked Transducer for Sonothrombolysis with a Combination of Nanodroplets and Magnetic Nanoparticles.
Hitesh Chopra, Shabana Bibi, Awdhesh Kumar Mishra, Vineet Tirth, Sree Vandana Yerramsetty, Sree Varshini Murali, Syed Umair Ahmad, Yugal Kishore Mohanta, Mohamed S. Attia, Ali Algahtani, Fahadul Islam, Abdul Hayee, Saiful Islam, Atif Amin Baig & Talha Bin Emran. (2022) Nanomaterials: A Promising Therapeutic Approach for Cardiovascular Diseases. Journal of Nanomaterials 2022, pages 1-25.
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Peter Ludewig, Matthias Graeser, Nils D. Forkert, Florian Thieben, Javier Rández‐Garbayo, Johanna Rieckhoff, Katrin Lessmann, Fynn Förger, Patryk Szwargulski, Tim Magnus & Tobias Knopp. (2021) Magnetic particle imaging for assessment of cerebral perfusion and ischemia. WIREs Nanomedicine and Nanobiotechnology 14:1.
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Ralf P. Friedrich, Iwona Cicha & Christoph Alexiou. (2021) Iron Oxide Nanoparticles in Regenerative Medicine and Tissue Engineering. Nanomaterials 11:9, pages 2337.
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Artur Y. Prilepskii, Anna F. Fakhardo, Andrey S. Drozdov, Vasiliy V. Vinogradov, Ivan P. Dudanov, Alexander A. Shtil, Petr P. Bel'tyukov, Alexey M. Shibeko, Ekaterina M. Koltsova, Dmitry Y. Nechipurenko & Vladimir V. Vinogradov. (2018) Urokinase-Conjugated Magnetite Nanoparticles as a Promising Drug Delivery System for Targeted Thrombolysis: Synthesis and Preclinical Evaluation. ACS Applied Materials & Interfaces 10:43, pages 36764-36775.
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Masumeh Zamanlu, Morteza Eskandani, Reza Mohammadian, Nazila Entekhabi, Mohammad Rafi & Mehdi Farhoudi. (2017) Spectrophotometric analysis of thrombolytic activity: SATA assay. BioImpacts 8:1, pages 31-38.
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