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International Journal of Nanomedicine Volume 7, 2012 - Issue
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Original Research

Intracellular CXCR4+ cell targeting with T22-empowered protein-only nanoparticles

Ugutz Unzueta1 Institut de Biotecnologia i de Biomedicina, Universitat Autònoma de Barcelona, Bellaterra, Barcelona;2 Departamento de Genètica i de Microbiologia, Universitat Autònoma de Barcelona, Bellaterra, Barcelona;3 CIBER en Bioingeniería, Biomateriales y Nanomedicina, Bellaterra, Barcelona
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María Virtudes Céspedes3 CIBER en Bioingeniería, Biomateriales y Nanomedicina, Bellaterra, Barcelona;4 Oncogenesis and Antitumor Drug Group, Biomedical Research Institute Sant Pau, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
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Neus Ferrer-Miralles1 Institut de Biotecnologia i de Biomedicina, Universitat Autònoma de Barcelona, Bellaterra, Barcelona;2 Departamento de Genètica i de Microbiologia, Universitat Autònoma de Barcelona, Bellaterra, Barcelona;3 CIBER en Bioingeniería, Biomateriales y Nanomedicina, Bellaterra, Barcelona
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Isolda Casanova3 CIBER en Bioingeniería, Biomateriales y Nanomedicina, Bellaterra, Barcelona;4 Oncogenesis and Antitumor Drug Group, Biomedical Research Institute Sant Pau, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
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Juan Cedano5 Laboratory of Immunology, Regional Norte, Universidad de la Republica, Salto, Uruguay
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José Luis Corchero1 Institut de Biotecnologia i de Biomedicina, Universitat Autònoma de Barcelona, Bellaterra, Barcelona;2 Departamento de Genètica i de Microbiologia, Universitat Autònoma de Barcelona, Bellaterra, Barcelona;3 CIBER en Bioingeniería, Biomateriales y Nanomedicina, Bellaterra, Barcelona
,
Joan Domingo-Espín1 Institut de Biotecnologia i de Biomedicina, Universitat Autònoma de Barcelona, Bellaterra, Barcelona;2 Departamento de Genètica i de Microbiologia, Universitat Autònoma de Barcelona, Bellaterra, Barcelona;3 CIBER en Bioingeniería, Biomateriales y Nanomedicina, Bellaterra, Barcelona
,
Antonio Villaverde1 Institut de Biotecnologia i de Biomedicina, Universitat Autònoma de Barcelona, Bellaterra, Barcelona;2 Departamento de Genètica i de Microbiologia, Universitat Autònoma de Barcelona, Bellaterra, Barcelona;3 CIBER en Bioingeniería, Biomateriales y Nanomedicina, Bellaterra, BarcelonaCorrespondence[email protected]
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Ramón Mangues3 CIBER en Bioingeniería, Biomateriales y Nanomedicina, Bellaterra, Barcelona;4 Oncogenesis and Antitumor Drug Group, Biomedical Research Institute Sant Pau, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
&
Esther Vázquez1 Institut de Biotecnologia i de Biomedicina, Universitat Autònoma de Barcelona, Bellaterra, Barcelona;2 Departamento de Genètica i de Microbiologia, Universitat Autònoma de Barcelona, Bellaterra, Barcelona;3 CIBER en Bioingeniería, Biomateriales y Nanomedicina, Bellaterra, Barcelona
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Pages 4533-4544 | Published online: 15 Aug 2012

Citations (19)

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Read on this site (1)

Neus Ferrer-Miralles, Escarlata Rodríguez-Carmona, José Luis Corchero, Elena García-Fruitós, Esther Vázquez & Antonio Villaverde. (2015) Engineering protein self-assembling in protein-based nanomedicines for drug delivery and gene therapy. Critical Reviews in Biotechnology 35:2, pages 209-221.
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Articles from other publishers (18)

Meichen Zhang & Haiyan Xu. (2023) Peptide-assembled nanoparticles targeting tumor cells and tumor microenvironment for cancer therapy. Frontiers in Chemistry 11.
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Giuseppe Bardi. (2022) Chemokines and nanomaterials: interaction for useful immune-applications. Exploration of Immunology, pages 637-647.
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Esperanza Medina-Gutiérrez, María Virtudes Céspedes, Alberto Gallardo, Elisa Rioja-Blanco, Miquel Àngel Pavón, Laura Asensio-Puig, Lourdes Farré, Lorena Alba-Castellón, Ugutz Unzueta, Antonio Villaverde, Esther Vázquez, Isolda Casanova & Ramon Mangues. (2022) Novel Endometrial Cancer Models Using Sensitive Metastasis Tracing for CXCR4-Targeted Therapy in Advanced Disease. Biomedicines 10:7, pages 1680.
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Naroa Serna, Aïda Falgàs, Annabel García-León, Ugutz Unzueta, Yáiza Núñez, Alejandro Sánchez-Chardi, Carlos Martínez-Torró, Ramón Mangues, Esther Vazquez, Isolda Casanova & Antonio Villaverde. (2022) Time-Prolonged Release of Tumor-Targeted Protein–MMAE Nanoconjugates from Implantable Hybrid Materials. Pharmaceutics 14:1, pages 192.
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Ramon Roca-Pinilla, Ravi Holani, Adrià López-Cano, Cristina Saubi, Ricardo Baltà-Foix, Eduardo R. Cobo, Elena Garcia-Fruitós & Anna Arís. (2021) Sequence edition of single domains modulates the final immune and antimicrobial potential of a new generation of multidomain recombinant proteins. Scientific Reports 11:1.
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Naroa Serna, José Vicente Carratalá, Oscar Conchillo-Solé, Carlos Martínez-Torró, Ugutz Unzueta, Ramón Mangues, Neus Ferrer-Miralles, Xavier Daura, Esther Vázquez & Antonio Villaverde. (2021) Antibacterial Activity of T22, a Specific Peptidic Ligand of the Tumoral Marker CXCR4. Pharmaceutics 13:11, pages 1922.
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Olivia Cano-Garrido, Patricia Álamo, Laura Sánchez-García, Aïda Falgàs, Alejandro Sánchez-Chardi, Naroa Serna, Eloi Parladé, Ugutz Unzueta, Mònica Roldán, Eric Voltà-Durán, Isolda Casanova, Antonio Villaverde, Ramón Mangues & Esther Vázquez. (2021) Biparatopic Protein Nanoparticles for the Precision Therapy of CXCR4+ Cancers. Cancers 13:12, pages 2929.
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Zeeshan Javed, Muhammad Javed Iqbal, Amna Rasheed, Haleema Sadia, Shahid Raza, Asma Irshad, Wojciech Koch, Wirginia Kukula-Koch, Anna Głowniak-Lipa, William C. Cho & Javad Sharifi-Rad. (2021) Regulation of Hedgehog Signaling by miRNAs and Nanoformulations: A Possible Therapeutic Solution for Colorectal Cancer. Frontiers in Oncology 10.
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Anissa Pisani, Roberto Donno, Arianna Gennari, Giulia Cibecchini, Federico Catalano, Roberto Marotta, Pier Paolo Pompa, Nicola Tirelli & Giuseppe Bardi. (2020) CXCL12-PLGA/Pluronic Nanoparticle Internalization Abrogates CXCR4-Mediated Cell Migration. Nanomaterials 10:11, pages 2304.
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Patricia Álamo, Victor Pallarès, María Virtudes Céspedes, Aïda Falgàs, Julieta M. Sanchez, Naroa Serna, Laura Sánchez-García, Eric Voltà-Duràn, Gordon A. Morris, Alejandro Sánchez-Chardi, Isolda Casanova, Ramón Mangues, Esther Vazquez, Antonio Villaverde & Ugutz Unzueta. (2020) Fluorescent Dye Labeling Changes the Biodistribution of Tumor-Targeted Nanoparticles. Pharmaceutics 12:11, pages 1004.
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Ping Yang, Yae Hu & Quansheng Zhou. (2020) The CXCL12-CXCR4 Signaling Axis Plays a Key Role in Cancer Metastasis and is a Potential Target for Developing Novel Therapeutics against Metastatic Cancer. Current Medicinal Chemistry 27:33, pages 5543-5561.
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Hèctor López-Laguna, Rafael Cubarsi, Ugutz Unzueta, Ramón Mangues, Esther Vázquez & Antonio Villaverde. (2019) Endosomal escape of protein nanoparticles engineered through humanized histidine-rich peptides. Science China Materials 63:4, pages 644-653.
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Zhen Luo, Fengze Miao, Menghong Hu & Youji Wang. (2020) Research Development on Horseshoe Crab: A 30-Year Bibliometric Analysis. Frontiers in Marine Science 7.
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Eric Voltà-Durán, Olivia Cano-Garrido, Naroa Serna, Hèctor López-Laguna, Laura Sánchez-García, Mireia Pesarrodona, Alejandro Sánchez-Chardi, Ramón Mangues, Antonio Villaverde, Esther Vázquez & Ugutz Unzueta. (2019) Controlling self-assembling and tumor cell-targeting of protein-only nanoparticles through modular protein engineering. Science China Materials 63:1, pages 147-156.
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Naroa Serna, Julieta M Sánchez, Ugutz Unzueta, Laura Sánchez-García, Alejandro Sánchez-Chardi, Ramón Mangues, Esther Vázquez & Antonio Villaverde. (2019) Recruiting potent membrane penetrability in tumor cell-targeted protein-only nanoparticles. Nanotechnology 30:11, pages 115101.
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Sara Cabrero-de las Heras & Eva Martínez-Balibrea. (2018) CXC family of chemokines as prognostic or predictive biomarkers and possible drug targets in colorectal cancer. World Journal of Gastroenterology 24:42, pages 4738-4749.
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Julieta M. Sánchez, Laura Sánchez-García, Mireia Pesarrodona, Naroa Serna, Alejandro Sánchez-Chardi, Ugutz Unzueta, Ramón Mangues, Esther Vázquez & Antonio Villaverde. (2018) Conformational Conversion during Controlled Oligomerization into Nonamylogenic Protein Nanoparticles. Biomacromolecules 19:9, pages 3788-3797.
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Ugutz Unzueta, Joaquin Seras-Franzoso, María Virtudes Céspedes, Paolo Saccardo, Francisco Cortés, Fabián Rueda, Elena Garcia-Fruitós, Neus Ferrer-Miralles, Ramon Mangues, Esther Vázquez & Antonio Villaverde. (2017) Engineering tumor cell targeting in nanoscale amyloidal materials. Nanotechnology 28:1, pages 015102.
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