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International Journal of Nanomedicine Volume 18, 2023 - Issue
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ORIGINAL RESEARCH

Surface Engineering of HEK293 Cell-Derived Extracellular Vesicles for Improved Pharmacokinetic Profile and Targeted Delivery of IL-12 for the Treatment of Hepatocellular Carcinoma

Jing Zhang1 State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, 102206, People’s Republic of China
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Haijing Song2 Emergency Medicine, PLA Strategic Support Force Medical Center, Beijing, 100101, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0002-3560-1629
ORCID Icon,
Yanan Dong1 State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, 102206, People’s Republic of China
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Ganghui Li3 China Pharmaceutical University, Nanjing, 211198, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0003-0272-999X
ORCID Icon,
Jun Li1 State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, 102206, People’s Republic of China
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Qizhe Cai4 Department of Echocardiography, Beijing Chao Yang Hospital, Capital Medical University, Beijing, 100020, People’s Republic of China
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Shoujun Yuan5 Beijing Institute of Radiation Medicine, Beijing, 100850, People’s Republic of China
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Yi Wang1 State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, 102206, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0002-4954-6317
ORCID Icon &
Haifeng Song1 State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, 102206, People’s Republic of ChinaCorrespondence[email protected] [email protected]
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Pages 209-223 | Received 09 Sep 2022, Accepted 24 Dec 2022, Published online: 13 Jan 2023

Citations (13)

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Read on this site (1)

Brandon M. Lehrich & Evan R. Delgado. (2024) Lipid Nanovesicle Platforms for Hepatocellular Carcinoma Precision Medicine Therapeutics: Progress and Perspectives. Organogenesis 20:1.
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Articles from other publishers (12)

Xiying Fan, Yiwen Zhang, Wenshuai Liu, Mingzheng Shao, Yibo Gong, Tingya Wang, Song Xue & Rui Nian. (2024) A comprehensive review of engineered exosomes from the preparation strategy to therapeutic applications. Biomaterials Science 12:14, pages 3500-3521.
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Yijun Chen, Jörg Kleeff & Yoshiaki Sunami. (2024) Pancreatic cancer cell- and cancer-associated fibroblast-derived exosomes in disease progression, metastasis, and therapy. Discover Oncology 15:1.
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Wooil Choi, Dong Jun Park & Brian P. Eliceiri. (2024) Defining tropism and activity of natural and engineered extracellular vesicles. Frontiers in Immunology 15.
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Ying-peng Xu, Tao Jiang, Xiao-fan Yang & Zhen-bing Chen. (2024) Methods, Mechanisms, and Application Prospects for Enhancing Extracellular Vesicle Uptake. Current Medical Science 44:2, pages 247-260.
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Kevin Jahnke & Oskar Staufer. (2024) Membranes on the move: The functional role of the extracellular vesicle membrane for contact‐dependent cellular signalling. Journal of Extracellular Vesicles 13:4.
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Yu Fu, Yuan-lin Zhang, Rong-qi Liu, Meng-meng Xu, Jun-ling Xie, Xing-liao Zhang, Guang-ming Xie, Yao-ting Han, Xin-Min Zhang, Wan-ting Zhang, Jing Zhang & Jun Zhang. (2024) Exosome lncRNA IFNG-AS1 derived from mesenchymal stem cells of human adipose ameliorates neurogenesis and ASD-like behavior in BTBR mice. Journal of Nanobiotechnology 22:1.
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Dong Jun Park, Wooil Choi, Sakeef Sayeed, Robert A. Dorschner, Joseph Rainaldi, Kayla Ho, Jenny Kezios, John P. Nolan, Prashant Mali, Todd Costantini & Brian P. Eliceiri. (2024) Defining the activity of pro-reparative extracellular vesicles in wound healing based on miRNA payloads and cell type-specific lineage mapping. Molecular Therapy.
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Jiayi Mao, Shutong Qian, Qiuyu Zhao, Binfan Zhao, Bolun Lu, Liucheng Zhang, Xiyuan Mao, Yuguang Zhang, Wenguo Cui & Xiaoming Sun. (2024) Balancing macrophage polarization via stem cell-derived apoptotic bodies for diabetic wound healing. Med 5:2, pages 148-168.e8.
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Leon F. Koch, Tatjana Best, Elena Wüstenhagen, Klaus Adrian, Oliver Rammo & Meike J. Saul. (2024) Novel insights into the isolation of extracellular vesicles by anion exchange chromatography. Frontiers in Bioengineering and Biotechnology 11.
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Shams GE Shams. (2024) Decoding the secrets of small extracellular vesicle communications: exploring the inhibition of vesicle-associated pathways and interception strategies for cancer treatment. American Journal of Cancer Research 14:5, pages 1957-1980.
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Sarwareddy Kartik Kumar & Manda Venkata Sasidhar. (2023) Recent Trends in the Use of Small Extracellular Vesicles as Optimal Drug Delivery Vehicles in Oncology. Molecular Pharmaceutics 20:8, pages 3829-3842.
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Caizheng Wang, Xiaoying Zhang, Jiahui Yu, Jiawen Bu, Xi Gu, Yue Wang, Xudong Zhu & Jie Lin. (2023) Spotlights on extracellular vesicles in hepatocellular carcinoma diagnosis and treatment: an update review. Frontiers in Bioengineering and Biotechnology 11.
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