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Original Research

Silymarin-loaded solid nanoparticles provide excellent hepatic protection: physicochemical characterization and in vivo evaluation

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Pages 3333-3343 | Published online: 28 Aug 2013

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Seyed Reza Mokhtari Sangdehi, Akbar Hajizadeh Moghaddam & Mojtaba Ranjbar. (2022) Anti-apoptotic effect of silymarin-loaded chitosan nanoparticles on hippocampal caspase-3 and Bcl-2 expression following cerebral ischemia/reperfusion injury. International Journal of Neuroscience 132:11, pages 1102-1109.
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Amira Mohamed Mohsen, Marwa Hasanein Asfour & Abeer A. A. Salama. (2017) Improved hepatoprotective activity of silymarin via encapsulation in the novel vesicular nanosystem bilosomes. Drug Development and Industrial Pharmacy 43:12, pages 2043-2054.
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Shilpa Chaudhary, Tarun Garg, R. S. R. Murthy, Goutam Rath & Amit K. Goyal. (2014) Recent approaches of lipid-based delivery system for lymphatic targeting via oral route. Journal of Drug Targeting 22:10, pages 871-882.
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Dong Yu Lim, Minyeong Pang, Jaehyeok Lee, Jihoon Lee, Ji-Hyeon Jeon, Jin-Hyang Park, Min-Koo Choi & Im-Sook Song. (2022) Enhanced bioavailability and hepatoprotective effect of silymarin by preparing silymarin-loaded solid dispersion formulation using freeze-drying method. Archives of Pharmacal Research 45:10, pages 743-760.
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Risako Onodera, Tomohiro Hayashi, Keiichi Motoyama, Kohei Tahara & Hirofumi Takeuchi. (2022) Hydroxypropyl-β-cyclodextrin Enhances Oral Absorption of Silymarin Nanoparticles Prepared Using PureNano™ Continuous Crystallizer. Pharmaceutics 14:2, pages 394.
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Ashitha Jose, Sreekanth K.Radhakrishnan E.K.. 2022. Advances in Nanotechnology-Based Drug Delivery Systems. Advances in Nanotechnology-Based Drug Delivery Systems 103 132 .
Anas Islam, Anuradha Mishra, Md Aftab Siddiqui & Saman Siddiquie. (2021) Recapitulation of Evidence of Phytochemical, Pharmacokinetic and Biomedical Application of Silybin. Drug Research 71:09, pages 489-503.
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Yu. I. Poltavets, S. L. Kuznetsov, I. A. Tubasheva, A. I. Murav’eva & N. V. Gukasova. (2021) Nano- and Microsized Forms of Silymarin and Silybin. Nanobiotechnology Reports 16:2, pages 115-137.
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Mikhail Durymanov, Anastasia Permyakova & Joshua Reineke. (2020) Pre-treatment With PLGA/Silibinin Nanoparticles Mitigates Dacarbazine-Induced Hepatotoxicity. Frontiers in Bioengineering and Biotechnology 8.
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Fatemeh Rezaee-Tazangi, Negar Varaa, Layasadat Khorsandi & Mohammadreza Abbaspour. (2020) Effects of Silymarin-Loaded Polylactic-co-Glycolic Acid Nanoparticles on Osteoarthritis in Rats. Iranian Journal of Science and Technology, Transactions A: Science 44:3, pages 605-614.
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Mohammad Zaidur Rahman Sabuj & Nazrul Islam. 2020. Nanophytomedicine. Nanophytomedicine 55 70 .
Swati Betharia, Alejandro N. Rondόn-Ortiz & Dennis A. Brown. (2019) Disubstituted Dithiolethione ACDT Exerts Neuroprotective Effects Against 6-Hydroxydopamine-Induced Oxidative Stress in SH-SY5Y Cells. Neurochemical Research 44:8, pages 1878-1892.
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Alfonso Di Costanzo & Ruggero Angelico. (2019) Formulation Strategies for Enhancing the Bioavailability of Silymarin: The State of the Art. Molecules 24:11, pages 2155.
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Hammad Ullah & Haroon Khan. (2018) Anti-Parkinson Potential of Silymarin: Mechanistic Insight and Therapeutic Standing. Frontiers in Pharmacology 9.
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Farnaz Monajjemzadeh, Mahsa Bagheri, Seyed Hassan Montazam & Mitra Jelvehgari. (2018) Preparation and In Vitro/Ex Vivo Evaluation of Buccoadhesive Discs of an Anti-Parkinson Drug: Relationship between Mucoadhesivity, Drug Release and Permeability. Pharmaceutical Sciences 24:1, pages 60-70.
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