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Original Research

Nanoparticulate Quillaja saponin induces apoptosis in human leukemia cell lines with a high therapeutic index

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Pages 51-62 | Published online: 06 Jan 2010

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Saideh Berenjian, Kefei Hu, Manuchehr Abedi-Valugerdi, Moustapha Hassan, Sadia Bashir Hassan & Bror Morein. (2014) The nanoparticulate Quillaja saponin KGI exerts anti-proliferative effects by down-regulation of cell cycle molecules in U937 and HL-60 human leukemia cells. Leukemia & Lymphoma 55:7, pages 1618-1624.
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Mayank Thakur, Matthias F Melzig, Hendrik Fuchs & Alexander Weng. (2011) Chemistry and pharmacology of saponins: special focus on cytotoxic properties. Botanics: Targets and Therapy 1, pages 19-29.
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Articles from other publishers (17)

Nazli Boke Sarikahya, Mohamed Chanfiou Mkouboi, Ayse Nalbantsoy & Murat Elibol. (2021) Cytotoxic and immunomodulator potential of hederagenin saponins from Cephalaria tchihatchewii. Phytochemistry Letters 44, pages 216-221.
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Waqas Ahmad, Maryam A. Shetab Boushehri & Alf Lamprecht. (2021) Polymeric matrix hydrophobicity governs saponin packing-density on nanoparticle surface and the subsequent biological interactions. Journal of Colloid and Interface Science 596, pages 500-513.
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Fernando Guerra & Sebastián Sepúlveda. (2021) Saponin production from Quillaja genus species. An insight into its applications and biology. Scientia Agricola 78:5.
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Noriko Komatsu, Miku Komatsu, Riuko Ohashi, Akira Horii, Kazuto Hoshi, Tsuyoshi Takato, Takahiro Abe & Takao Hamakubo. (2020) Saponin Facilitates Anti-Robo1 Immunotoxin Cytotoxic Effects on Maxillary Sinus Squamous Cell Carcinoma. Journal of Oncology 2020, pages 1-8.
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Chunfang Zhu, Meng Zhang, Qiaoling Tang, Qian Yang, Jing Li, Xuan He & Yong Ye. (2019) Structure and Activity of the Camellia oleifera Sapogenin Derivatives on Growth and Biofilm Inhibition of Staphylococcus aureus and Escherichia coli . Journal of Agricultural and Food Chemistry 67:51, pages 14143-14151.
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R R C New. (2019) Formulation technologies for oral vaccines. Clinical and Experimental Immunology 198:2, pages 153-169.
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Juliane Deise Fleck, Andresa Heemann Betti, Francini Pereira Da Silva, Eduardo Artur Troian, Cristina Olivaro, Fernando Ferreira & Simone Gasparin Verza. (2019) Saponins from Quillaja saponaria and Quillaja brasiliensis: Particular Chemical Characteristics and Biological Activities. Molecules 24:1, pages 171.
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Oznur Akbal, Tayfun Vural, Soheil Malekghasemi, Betül Bozdoğan & Emir Baki Denkbaş. (2018) Saponin loaded montmorillonite-human serum albumin nanocomposites as drug delivery system in colorectal cancer therapy. Applied Clay Science 166, pages 214-222.
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Radwa R. Mosad, Mohamed H. Ali, Magda T. Ibrahim, Hala M. Shaaban, Marwan Emara & Amir E. Wahba. (2017) New cytotoxic steroidal saponins from Cestrum parqui. Phytochemistry Letters 22, pages 167-173.
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Maohui Chen, Vinod Balhara, Ana Maria Jaimes Castillo, John Balsevich & Linda J. Johnston. (2017) Interaction of saponin 1688 with phase separated lipid bilayers. Biochimica et Biophysica Acta (BBA) - Biomembranes 1859:7, pages 1263-1272.
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Sonia Trombino, Roberta Cassano, Silvia Mellace, Nevio Picci, Monica R Loizzo, Francesco Menichini & Rosa Tundis. (2016) Novel microspheres based on triterpene saponins from the roots of Physospermum verticillatum (Waldst & Kit) (Apiaceae) for the improvement of gemcitabine release . Journal of Pharmacy and Pharmacology 68:2, pages 275-281.
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Joseph H. Lorent, Joëlle Quetin-Leclercq & Marie-Paule Mingeot-Leclercq. (2014) The amphiphilic nature of saponins and their effects on artificial and biological membranes and potential consequences for red blood and cancer cells. Org. Biomol. Chem. 12:44, pages 8803-8822.
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Christopher Bachran, Silke Bachran, Mark Sutherland, Diana Bachran & Hendrik Fuchs. 2014. Recent Advances in Medicinal Chemistry. Recent Advances in Medicinal Chemistry 272 302 .
Pedro Da Silva, Vanessa Eyraud, Maïté Carre-Pierrat, Catherine Sivignon, Isabelle Rahioui, Corinne Royer & Frédéric Gressent. (2012) High toxicity and specificity of the saponin 3-GlcA-28-AraRhaxyl-medicagenate, from Medicago truncatula seeds, for Sitophilus oryzae. BMC Chemical Biology 12:1.
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Eli Harlev, Eviatar Nevo, Ephraim P. Lansky, Shifra Lansky & Anupam Bishayee. (2012) Anticancer attributes of desert plants. Anti-Cancer Drugs 23:3, pages 255-271.
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H. Van de Ven, M. Vermeersch, A. Matheeussen, J. Vandervoort, W. Weyenberg, S. Apers, P. Cos, L. Maes & A. Ludwig. (2011) PLGA nanoparticles loaded with the antileishmanial saponin β-aescin: Factor influence study and in vitro efficacy evaluation. International Journal of Pharmaceutics 420:1, pages 122-132.
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Johan Bankefors, Susanna Broberg, Lars I. Nord & Lennart Kenne. (2011) Electrospray ionization ion-trap multiple-stage mass spectrometry of Quillaja saponins. Journal of Mass Spectrometry 46:7, pages 658-665.
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