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Original Research

Enhanced oral bioavailability of fenofibrate using polymeric nanoparticulated systems: physicochemical characterization and in vivo investigation

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Pages 1819-1830 | Published online: 05 Mar 2015

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Read on this site (12)

Lin Zhao, Omer Mustapha, Shumaila Shafique, Talha Jamshaid, Fakhar ud Din, Yasir Mehmood, Khaleeq Anwer, Qurrat ul Ain Yousafi, Talib Hussain, Ikram Ullah Khan, Muhammad Usman Ghori, Yasser Shahzad & Abid Mehmood Yousaf. (2020) Electrospun Gelatin Nanocontainers for Enhanced Biopharmaceutical Performance of Piroxicam: In Vivo and In Vitro Investigations. International Journal of Nanomedicine 15, pages 8819-8828.
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Ru Sun, Chengwu Shen, Shumaila Shafique, Omer Mustapha, Talib Hussain, Ikram Ullah Khan, Yasir Mehmood, Khaleeq Anwer, Yasser Shahzad & Abid Mehmood Yousaf. (2020) Electrosprayed Polymeric Nanospheres for Enhanced Solubility, Dissolution Rate, Oral Bioavailability and Antihyperlipidemic Activity of Bezafibrate. International Journal of Nanomedicine 15, pages 705-715.
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Rasha A. Alshaikh, Ebtessam A. Essa & Gamal M. El Maghraby. (2020) Preparation of stabilized submicron fenofibrate crystals on niacin as a hydrophilic hydrotropic carrier. Pharmaceutical Development and Technology 25:2, pages 168-177.
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Jong Hyuck Park, Jung Hyun Cho, Dong Shik Kim, Jung Suk Kim, Fakhar Ud Din, Jong Oh Kim, Chul Soon Yong, Yu Seok Youn, Kyung Taek Oh, Dong Wuk Kim & Han-Gon Choi. (2019) Revaprazan-loaded surface-modified solid dispersion: physicochemical characterization and in vivo evaluation. Pharmaceutical Development and Technology 24:6, pages 788-793.
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Abid Mehmood Yousaf, Muhammad Ramzan, Yasser Shahzad, Tariq Mahmood & Muhammad Jamshaid. (2019) Fabrication and in vitro characterization of fenofibric acid-loaded hyaluronic acid–polyethylene glycol polymeric composites with enhanced drug solubility and dissolution rate. International Journal of Polymeric Materials and Polymeric Biomaterials 68:9, pages 510-515.
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Jung Suk Kim, Jong Hyuck Park, Sung Chan Jeong, Dong Shik Kim, Abid Mehmood Yousaf, Fakhar Ud Din, Jong Oh Kim, Chul Soon Yong, Yu Seok Youn, Kyung Taek Oh, Sung Giu Jin & Han-Gon Choi. (2018) Novel revaprazan-loaded gelatin microsphere with enhanced drug solubility and oral bioavailability. Journal of Microencapsulation 35:5, pages 421-427.
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Ahmed H. Ibrahim, Hany M. Ibrahim, Hatem R. Ismael & Ahmed M. Samy. (2018) Optimization and evaluation of lyophilized fenofibrate nanoparticles with enhanced oral bioavailability and efficacy. Pharmaceutical Development and Technology 23:4, pages 358-369.
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Kyeong Soo Kim, Eun Su Yang, Dong Shik Kim, Dong Wuk Kim, Hye Hyun Yoo, Chul Soon Yong, Yu Seok Youn, Kyung Taek Oh, Jun-Pil Jee, Jong Oh Kim, Sung Giu Jin & Han Gon Choi. (2017) A novel solid self-nanoemulsifying drug delivery system (S-SNEDDS) for improved stability and oral bioavailability of an oily drug, 1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol. Drug Delivery 24:1, pages 1018-1025.
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Abid Mehmood Yousaf, Omer Mustapha, Dong Wuk Kim, Dong Shik Kim, Kyeong Soo Kim, Sung Giu Jin, Chul Soon Yong, Yu Seok Youn, Yu-Kyoung Oh, Jong Oh Kim & Han-Gon Choi. (2016) Novel electrosprayed nanospherules for enhanced aqueous solubility and oral bioavailability of poorly water-soluble fenofibrate. International Journal of Nanomedicine 11, pages 213-221.
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Sabyasachi Banerjee, K. Ravi Shankar & Rajendra Prasad Y.. (2016) Formulation development and systematic optimization of stabilized ziprasidone hydrochloride capsules devoid of any food effect. Pharmaceutical Development and Technology 21:7, pages 775-786.
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Abid Mehmood Yousaf, Dong Wuk Kim, Dong Shik Kim, Jong Oh Kim, Yu Seok Youn, Kwan Hyung Cho, Chul Soon Yong & Han-Gon Choi. (2016) Influence of polyvinylpyrrolidone quantity on the solubility, crystallinity and oral bioavailability of fenofibrate in solvent-evaporated microspheres. Journal of Microencapsulation 33:4, pages 365-371.
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Omer Mustapha, Fakhar ud Din, Dong Wuk Kim, Jong Hyuck Park, Kyu Bong Woo, Soo-Jeong Lim, Yu Seok Youn, Kwan Hyung Cho, Rehmana Rashid, Abid Mehmood Yousaf, Jong Oh Kim, Chul Soon Yong & Han-Gon Choi. (2016) Novel piroxicam-loaded nanospheres generated by the electrospraying technique: physicochemical characterisation and oral bioavailability evaluation. Journal of Microencapsulation 33:4, pages 323-330.
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Kaiyue Du, Xin Huang, Ankang Peng, Qinghua Yang, Du Chen, Jianxiang Zhang & Rong Qi. (2022) Engineered Fenofibrate as Oxidation-Sensitive Nanoparticles with ROS Scavenging and PPARα-Activating Bioactivity to Ameliorate Nonalcoholic Fatty Liver Disease. Molecular Pharmaceutics 20:1, pages 159-171.
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Saed Abbasi, Haruki Higashino, Yusuke Sato, Keiko Minami, Makoto Kataoka, Shinji Yamashita & Hideyoshi Harashima. (2021) Maximizing the Oral Bioavailability of Poorly Water-Soluble Drugs Using Novel Oil-Like Materials in Lipid-Based Formulations. Molecular Pharmaceutics 18:9, pages 3281-3289.
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Fangfang Qiu, Tuo Meng, Qian Chen, Kelu Zhou, Yan Shao, Greg Matlock, Xiang Ma, Wenjing Wu, Yanhong Du, Xiang Wang, Guotao Deng, Jian-xing Ma & Qingguo Xu. (2019) Fenofibrate-Loaded Biodegradable Nanoparticles for the Treatment of Experimental Diabetic Retinopathy and Neovascular Age-Related Macular Degeneration. Molecular Pharmaceutics 16:5, pages 1958-1970.
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