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International Journal of Nanomedicine Volume 10, 2015 - Issue
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Original Research

Probing insulin bioactivity in oral nanoparticles produced by ultrasonication-assisted emulsification/internal gelation

Marlene A Lopes1 Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal;2 CNC – Center for Neuroscience and Cell Biology, Coimbra, Portugal
,
Bárbara Abrahim-Vieira3 Department of Pharmaceutics, Faculty of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
,
Claudia Oliveira4 I3S, Instituto de Investigação e Inovação em Saúde, University of Porto, Porto, Portugal;5 Group Genetics of Cognitive Dysfunction, IBMC – Instituto de Biologia Molecular e Celular, Porto, Portugal
,
Pedro Fonte6 REQUIMTE, Department of Chemical Sciences – Applied Chemistry Lab, Faculty of Pharmacy, University of Porto, Porto, Portugal;7 CESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Gandra, Portugal
,
Alessandra M T Souza3 Department of Pharmaceutics, Faculty of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
,
Tammy Lira3 Department of Pharmaceutics, Faculty of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
,
Joana A D Sequeira1 Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal;2 CNC – Center for Neuroscience and Cell Biology, Coimbra, Portugal
,
Carlos R Rodrigues3 Department of Pharmaceutics, Faculty of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
,
Lúcio M Cabral3 Department of Pharmaceutics, Faculty of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
,
Bruno Sarmento6 REQUIMTE, Department of Chemical Sciences – Applied Chemistry Lab, Faculty of Pharmacy, University of Porto, Porto, Portugal;7 CESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Gandra, Portugal;8 INEB – Instituto de Engenharia Biomédica, University of Porto, Porto, Portugal
,
Raquel Seiça9 IBILI – Institute of Biomedical Research in Light and Image, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
,
Francisco Veiga1 Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal;2 CNC – Center for Neuroscience and Cell Biology, Coimbra, Portugal
&
António J Ribeiro1 Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal;4 I3S, Instituto de Investigação e Inovação em Saúde, University of Porto, Porto, Portugal;5 Group Genetics of Cognitive Dysfunction, IBMC – Instituto de Biologia Molecular e Celular, Porto, PortugalCorrespondence[email protected]
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Pages 5865-5880 | Published online: 18 Sep 2015

Citations (15)

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Suchitra Kumari Panigrahy & Awanish Kumar. (2022) Biopolymeric nanocarrier: an auspicious system for oral delivery of insulin. Journal of Biomaterials Science, Polymer Edition 33:16, pages 2145-2164.
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Chun Y. Wong, Hani Al-Salami & Crispin R. Dass. (2021) Fabrication techniques for the preparation of orally administered insulin nanoparticles. Journal of Drug Targeting 29:4, pages 365-386.
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Chun Y. Wong, Hani Al-Salami & Crispin R. Dass. (2020) Current status and applications of animal models in pre-clinical development of orally administered insulin-loaded nanoparticles. Journal of Drug Targeting 28:9, pages 882-903.
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Chun Y. Wong, Jorge Martinez, Jian Zhao, Hani Al-Salami & Crispin R. Dass. (2020) Development of orally administered insulin-loaded polymeric-oligonucleotide nanoparticles: statistical optimization and physicochemical characterization. Drug Development and Industrial Pharmacy 46:8, pages 1238-1252.
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Daniela Nadvorny, José Lamartine Soares-Sobrinho, Monica F. de La Roca Soares, Antônio José Ribeiro, Francisco Veiga & Gustavo M. Seabra. (2018) Molecular dynamics simulations reveal the influence of dextran sulfate in nanoparticle formation with calcium alginate to encapsulate insulin. Journal of Biomolecular Structure and Dynamics 36:5, pages 1255-1260.
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Marlene Lopes, Barbara Abrahim, Francisco Veiga, Raquel Seiça, Lucio Mendes Cabral, Philippe Arnaud, José Carlos Andrade & Antonio J. Ribeiro. (2017) Preparation methods and applications behind alginate-based particles. Expert Opinion on Drug Delivery 14:6, pages 769-782.
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Chia Miang Khor, Wai Kiong Ng, Parijat Kanaujia, Kok Ping Chan & Yuancai Dong. (2017) Hot-melt extrusion microencapsulation of quercetin for taste-masking. Journal of Microencapsulation 34:1, pages 29-37.
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Articles from other publishers (8)

Bruno Pessoa, Mar Collado-Gonzalez, Giuseppina Sandri & António Ribeiro. (2023) Chitosan/Albumin Coating Factorial Optimization of Alginate/Dextran Sulfate Cores for Oral Delivery of Insulin. Marine Drugs 21:3, pages 179.
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Preeti Yadav & Awadh Bihari Yadav. 2022. Composite Materials for Extreme Loading. Composite Materials for Extreme Loading 73 86 .
Hazem Choukaife, Abd Almonem Doolaanea & Mulham Alfatama. (2020) Alginate Nanoformulation: Influence of Process and Selected Variables. Pharmaceuticals 13:11, pages 335.
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Krishna Yadav, Nagendra Singh Chauhan, Swarnlata Saraf, Deependra Singh & Manju Rawat Singh. 2020. Advances and Avenues in the Development of Novel Carriers for Bioactives and Biological Agents. Advances and Avenues in the Development of Novel Carriers for Bioactives and Biological Agents 1 36 .
Quancai Sun, Zipei Zhang, Ruojie Zhang, Ruichang Gao & David Julian McClements. (2018) Development of Functional or Medical Foods for Oral Administration of Insulin for Diabetes Treatment: Gastroprotective Edible Microgels. Journal of Agricultural and Food Chemistry 66:19, pages 4820-4826.
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Maria T. Bezem, Fredrik G. Johannessen, Kunwar Jung-KC, Edvin Tang Gundersen, Ana Jorge-Finnigan, Ming Ying, Didier Betbeder, Lars Herfindal & Aurora Martinez. (2018) Stabilization of Human Tyrosine Hydroxylase in Maltodextrin Nanoparticles for Delivery to Neuronal Cells and Tissue. Bioconjugate Chemistry 29:2, pages 493-502.
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Xiaoyang Guan, Patrick K. Chaffey, Xiuli Wei, Daniel R Gulbranson, Yuan Ruan, Xinfeng Wang, Yaohao Li, Yan Ouyang, Liqun Chen, Chen Zeng, Theo N. Koelsch, Amy H. Tran, Wei Liang, Jingshi Shen & Zhongping Tan. (2017) Chemically Precise Glycoengineering Improves Human Insulin. ACS Chemical Biology 13:1, pages 73-81.
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Sunandini Chopra, Nicolas Bertrand, Jong-Min Lim, Amy Wang, Omid C. Farokhzad & Rohit Karnik. (2017) Design of Insulin-Loaded Nanoparticles Enabled by Multistep Control of Nanoprecipitation and Zinc Chelation. ACS Applied Materials & Interfaces 9:13, pages 11440-11450.
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