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Original Research

Numerical optimization of targeted delivery of charged nanoparticles to the ostiomeatal complex for treatment of rhinosinusitis

Jinxiang Xi1 School of Engineering and Technology, Central Michigan University, Mount Pleasant, MI, USACorrespondence[email protected]

Jiayao Eddie Yuan1 School of Engineering and Technology, Central Michigan University, Mount Pleasant, MI, USA

Xiuhua April Si2 Department of Mechanical Engineering, California Baptist University, Riverside, CA, USA

James Hasbany1 School of Engineering and Technology, Central Michigan University, Mount Pleasant, MI, USA

Pages 4847-4861 | Published online: 30 Jul 2015

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Xiuhua A. Si, Mohamed Talaat & Jinxiang Xi. (2023) Effects of guiding vanes and orifice jet flow of a metered-dose inhaler on drug dosimetry in human respiratory tract. Experimental and Computational Multiphase Flow 5:3, pages 247-261.
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Ahmed Alharbi, Nicolas Reville, Sandrine Molinier, Pierre-Louis Bastier & Ludovic de Gabory. (2022) Characterization of fungus ball CT-hyperdensities within maxillary and sphenoid sinuses. Dentomaxillofacial Radiology 51:6.
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Mohamed Talaat, Xiuhua Si, Xiaofei Liu & Jinxiang Xi. (2022) Count- and mass-based dosimetry of MDI spray droplets with polydisperse and monodisperse size distributions. International Journal of Pharmaceutics 623, pages 121920.
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Mohamed Talaat, Xiuhua Si & Jinxiang Xi. (2022) Lower Inspiratory Breathing Depth Enhances Pulmonary Delivery Efficiency of ProAir Sprays. Pharmaceuticals 15:6, pages 706.
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Mohamed Talaat, Xiuhua Si & Jinxiang Xi. (2022) Effect of MDI Actuation Timing on Inhalation Dosimetry in a Human Respiratory Tract Model. Pharmaceuticals 15:1, pages 61.
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Jinxiang Xi, Mohamed Talaat & Xiuhua April Si. (2022) Two-way coupling and Kolmogorov scales on inhaler spray plume evolutions from Ventolin, ProAir, and Qvar. Mathematical Biosciences and Engineering 19:11, pages 10915-10940.
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Zilong Wang & Marianthi Ierapetritou. 2022. How to Design and Implement Powder-To-Tablet Continuous Manufacturing Systems. How to Design and Implement Powder-To-Tablet Continuous Manufacturing Systems 271 299 .

John Chen, Andrew R. Martin & Warren H. Finlay. (2021) Recent In Vitro and In Silico Advances in the Understanding of Intranasal Drug Delivery. Current Pharmaceutical Design 27:12, pages 1482-1497.
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Ali Farnoud, Ingo Baumann, Mohammad Mehdi Rashidi, Otmar Schmid & Eva Gutheil. (2020) Simulation of patient-specific bi-directional pulsating nasal aerosol dispersion and deposition with clockwise 45° and 90° nosepieces. Computers in Biology and Medicine 123, pages 103816.
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Oveis Pourmehran, Maziar Arjomandi, Benjamin Cazzolato, Farzin Ghanadi & Zhao Tian. (2019) The impact of geometrical parameters on acoustically driven drug delivery to maxillary sinuses. Biomechanics and Modeling in Mechanobiology 19:2, pages 557-575.
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V. Covello, C. Pipolo, A. Saibene, G. Felisati & M. Quadrio. (2018) Numerical simulation of thermal water delivery in the human nasal cavity. Computers in Biology and Medicine 100, pages 62-73.
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Jinxiang Xi, Xiuhua April Si, Shannon Peters, Dannielle Nevorski, Tianshu Wen & Mark Lehman. (2017) Understanding the mechanisms underlying pulsating aerosol delivery to the maxillary sinus: In vitro tests and computational simulations. International Journal of Pharmaceutics 520:1-2, pages 254-266.
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Jinxiang Xi, Xiuhua A. Si, Jongwon Kim, Yu Zhang, Richard E. Jacob, Senthil Kabilan & Richard A. Corley. (2016) Anatomical Details of the Rabbit Nasal Passages and Their Implications in Breathing, Air Conditioning, and Olfaction. The Anatomical Record 299:7, pages 853-868.
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Jinxiang Xi, Jiayao Eddie Yuan & Xiuhua April Si. (2016) Simulation study of electric-guided delivery of 0.4µm monodisperse and polydisperse aerosols to the ostiomeatal complex. Computers in Biology and Medicine 72, pages 1-12.
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Numerical optimization of targeted delivery of charged nanoparticles to the ostiomeatal complex for treatment of rhinosinusitis

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Numerical optimization of targeted delivery of charged nanoparticles to the ostiomeatal complex for treatment of rhinosinusitis

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