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Original Research

Local delivery of controlled-release simvastatin to improve the biocompatibility of polyethylene terephthalate artificial ligaments for reconstruction of the anterior cruciate ligament

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Pages 465-478 | Published online: 27 Jan 2016

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Read on this site (5)

Zeynep Karahaliloglu, Batur Ercan & Baki Hazer. (2023) Impregnation of polyethylene terephthalate (PET) grafts with BMP-2 loaded functional nanoparticles for reconstruction of anterior cruciate ligament. Journal of Microencapsulation 40:3, pages 197-215.
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De-Sheng Chen, Tong-Fu Wang, Jia-Wang Zhu, Bo Zhu, Zeng-Liang Wang, Jian-Gang Cao, Cai-Hong Feng & Jun-Wei Zhao. (2021) A Novel Application of Unsupervised Machine Learning and Supervised Machine Learning-Derived Radiomics in Anterior Cruciate Ligament Rupture. Risk Management and Healthcare Policy 14, pages 2657-2664.
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Xiaoquan Ding, Siheng Wang, Wenhe Jin, Xingwang Liu, Jun Chen & Shiyi Chen. (2019) Encapsulation of a nanoporous simvastatin-chitosan composite to enhance osteointegration of hydroxyapatite-coated polyethylene terephthalate ligaments. International Journal of Nanomedicine 14, pages 4881-4893.
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Min Lai, Xufeng Yan & Ziyang Jin. (2018) The response of bone cells to titanium surfaces modified by simvastatin-loaded multilayered films. Journal of Biomaterials Science, Polymer Edition 29:15, pages 1895-1908.
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Zhaoying Wu, Quan Li, Yongkang Pan, Yuan Yao, Songchao Tang, Jiacan Su, Jung-Woog Shin, Jie Wei & Jun Zhao. (2017) Nanoporosity improved water absorption, in vitro degradability, mineralization, osteoblast responses and drug release of poly(butylene succinate)-based composite scaffolds containing nanoporous magnesium silicate compared with magnesium silicate. International Journal of Nanomedicine 12, pages 3637-3651.
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Articles from other publishers (22)

Claudio Legnani & Alberto Ventura. (2023) Synthetic grafts for anterior cruciate ligament reconstructive surgery. Medical Engineering & Physics 117, pages 103992.
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Hui Huang, Jian Chen, Zhengkun Lin & Xiaomei Lin. (2023) Rubiadin Regulates Bone Metabolism in Ovariectomized Rat Model by Inhibition of osteoclast formation and differentiation. ChemistrySelect 8:11.
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Yijia Sun, Zirong Huang, Pingquan Zhang, Huanyu Xie, Chen Wang, Zhenhan Deng, Kang Chen & Weimin Zhu. (2023) Comparative Study of Graft Healing in 2 Years after “Tension Suspension” Remnant-Preserving and Non-Remnant-Preserving Anatomical Reconstruction for Sherman Type II Anterior Cruciate Ligament Injury. Journal of Personalized Medicine 13:3, pages 477.
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Olga Urbanek, Maryla Moczulska-Heljak, Mikołaj Wróbel, Andrzej Mioduszewski & Dorota Kołbuk. (2023) Advanced Graft Development Approaches for ACL Reconstruction or Regeneration. Biomedicines 11:2, pages 507.
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Qubo Ni, Jiayong Zhu, Zhenyu Li, Bin Li, Hui Wang & Liaobin Chen. (2022) Simvastatin promotes rat Achilles tendon-bone interface healing by promoting osteogenesis and chondrogenic differentiation of stem cells. Cell and Tissue Research 391:2, pages 339-355.
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Apoorva Sharma, Kavitha Sanjeev, Vinola M. J. Selvanathan, Mahalaxmi Sekar & Nikhil Harikrishnan. (2022) The evaluation of cytotoxicity and cytokine IL-6 production of root canal sealers with and without the incorporation of simvastatin: an invitro study. BMC Oral Health 22:1.
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Wenhe Jin, Jiangyu Cai, Dandan Sheng, Xingwang Liu, Jun Chen & Shiyi Chen. (2021) Establishment of near and non isometric anterior cruciate ligament reconstruction with artificial ligament in a rabbit model. Journal of Orthopaedic Translation 29, pages 78-88.
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Hui Jin, Youbo Ji, Yutao Cui, Li Xu, He Liu & Jincheng Wang. (2021) Simvastatin-Incorporated Drug Delivery Systems for Bone Regeneration. ACS Biomaterials Science & Engineering 7:6, pages 2177-2191.
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Song Shi, Wentao Fan, Ran Tao, Hua Xu, Yue Lu, Fei Han, Shuaijie Yang, Xinyu Zhou, Zhenyu Zhou & Fuyin Wan. (2020) Natural Biomineralization-Inspired Magnesium Silicate Composite Coating Upregulates Osteogenesis, Enabling Strong Anterior Cruciate Ligament Graft–Bone Healing In Vivo. ACS Biomaterials Science & Engineering 7:1, pages 133-143.
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Lays Fernanda Nunes Dourado, Amauri Pierucci, Juan Pedro Bretas Roa & Álvaro Dutra de Carvalho Júnior. (2021) Assessment of implantable drug delivery technology: poly (3-hydroxybutyrate) / polypropylene glycol films containing simvastatin. Matéria (Rio de Janeiro) 26:4.
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Lalit Kumar Meena, Hilal Ahmad Rather & Rajesh Vasita. (2020) Single-Step Fabrication of Core–Shell Microgels for the Controlled Release of rhBMP-2 and Simvastatin to Induce Osteogenesis. ACS Applied Polymer Materials 2:11, pages 4902-4913.
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Peng Zhang, Fei Han, Tianwu Chen, Ziying Wu & Shiyi Chen. (2020) “Swiss roll”-like bioactive hybrid scaffolds for promoting bone tissue ingrowth and tendon-bone healing after anterior cruciate ligament reconstruction. Biomaterials Science 8:3, pages 871-883.
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Kai Zhu, Futing Zhao, Yanhua Yang & Weidong Mu. (2019) Effects of simvastatin‑loaded PLGA microspheres on treatment of rats with intervertebral disk degeneration and on 6‑K‑PGF1α and HIF‑1α. Experimental and Therapeutic Medicine.
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Jianjun Yang, Yu Dong, Jianguang Wang, Chen Chen, Yuchang Zhu, Yang Wu, Peng Zhang, Tianwu Chen, Weifeng Zhou, Peiyi Wu, Nguyen T. K. Thanh, Ngoc Quyên Trân, Jun Chen & Shiyi Chen. (2019) Hydroxypropylcellulose Coating to Improve Graft-to-Bone Healing for Anterior Cruciate Ligament Reconstruction. ACS Biomaterials Science & Engineering 5:4, pages 1793-1803.
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Wencheng Liang, Jia Hou, Xiangchen Fang, Fudong Bai, Tonghe Zhu, Feifei Gao, Chao Wei, Xiumei Mo & Meidong Lang. (2018) Synthesis of cellulose diacetate based copolymer electrospun nanofibers for tissues scaffold. Applied Surface Science 443, pages 374-381.
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A. T. HexterT. ThangarajahG. BlunnF. S. Haddad. (2018) Biological augmentation of graft healing in anterior cruciate ligament reconstruction. The Bone & Joint Journal 100-B:3, pages 271-284.
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Yu Li, Zhanzhao Zhang & Zhiyong Zhang. (2018) Porous Chitosan/Nano-Hydroxyapatite Composite Scaffolds Incorporating Simvastatin-Loaded PLGA Microspheres for Bone Repair. Cells Tissues Organs 205:1, pages 20-31.
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Hong Li, Jinyan Li, Jia Jiang, Fang Lv, Jiang Chang, Shiyi Chen & Chengtie Wu. (2017) An osteogenesis/angiogenesis-stimulation artificial ligament for anterior cruciate ligament reconstruction. Acta Biomaterialia 54, pages 399-410.
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Min Lai, Ziyang Jin, Xinyi Yang, Huaying Wang & Kui Xu. (2017) The controlled release of simvastatin from TiO2 nanotubes to promote osteoblast differentiation and inhibit osteoclast resorption. Applied Surface Science 396, pages 1741-1751.
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Rowan P. Rimington, Andrew J. Capel, Steven D. R. Christie & Mark P. Lewis. (2017) Biocompatible 3D printed polymers via fused deposition modelling direct C 2 C 12 cellular phenotype in vitro . Lab on a Chip 17:17, pages 2982-2993.
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Johanna Buschmann & Gabriella Meier Bürgisser. 2017. Biomechanics of Tendons and Ligaments. Biomechanics of Tendons and Ligaments 319 331 .
Yaying Sun, Fei Han, Peng Zhang, Yunlong Zhi, Jianjun Yang, Xiaohan Yao, Hui Wang, Chao Lin, Xuejun Wen, Jiwu Chen & Peng Zhao. (2016) A synthetic bridging patch of modified co-electrospun dual nano-scaffolds for massive rotator cuff tear. Journal of Materials Chemistry B 4:45, pages 7259-7269.
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