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Review

Vaginal rings for delivery of HIV microbicides

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Pages 595-605 | Published online: 20 Nov 2012

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Peter Boyd, Ruth Merkatz, Bruce Variano & R. Karl Malcolm. (2020) The ins and outs of drug-releasing vaginal rings: a literature review of expulsions and removals. Expert Opinion on Drug Delivery 17:11, pages 1519-1540.
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Denise A. Cobb, Nathan A. Smith, Benson J. Edagwa & JoEllyn M. McMillan. (2020) Long-acting approaches for delivery of antiretroviral drugs for prevention and treatment of HIV: a review of recent research. Expert Opinion on Drug Delivery 17:9, pages 1227-1238.
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Veronika Nováková Tkadlečková, Jakub Vysloužil, Kateřina Kubová, Jan Elbl, Darja Bučková, Jan Muselík, David Vetchý, Robert Novotný, Pavel Proks, Josef Jančář & Petr Poláček. (2019) The development of a silicone vaginal ring with a prostaglandin analogue for potential use in the treatment of canine reproductive disorders. Pharmaceutical Development and Technology 24:8, pages 1021-1031.
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Ilza Monteiro, Cristina Falbo Guazzelli & Luis Bahamondes. (2018) Advances in contraceptive vaginal rings: what does the future hold?. Expert Opinion on Pharmacotherapy 19:15, pages 1685-1691.
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Andrea Ries Thurman, Meredith R Clark, Jennifer A Hurlburt & Gustavo F Doncel. (2013) Intravaginal rings as delivery systems for microbicides and multipurpose prevention technologies. International Journal of Women's Health 5, pages 695-708.
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Satish Kumar Gupta & Nutan. (2013) Clinical use of vaginal or rectally applied microbicides in patients suffering from HIV/AIDS. HIV/AIDS - Research and Palliative Care 5, pages 295-307.
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Edina Vranić. 2023. Nano- and Microfabrication Techniques in Drug Delivery. Nano- and Microfabrication Techniques in Drug Delivery 275 294 .
Clare F. McCoy, Patrick Spence, Yahya H. Dallal Bashi, Diarmaid J. Murphy, Peter Boyd, Bindi Dangi, Tiffany Derrick, Bríd Devlin, Kyle Kleinbeck & R. Karl Malcolm. (2021) Use of simulated vaginal and menstrual fluids to model in vivo discolouration of silicone elastomer vaginal rings. International Journal of Pharmaceutics: X 3, pages 100081.
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Petra Arany, Ildikó Papp, Marianna Zichar, Géza RegdonJr.Jr., Mónika Béres, Melinda Szalóki, Renátó Kovács, Pálma Fehér, Zoltán Ujhelyi, Miklós Vecsernyés & Ildikó Bácskay. (2021) Manufacturing and Examination of Vaginal Drug Delivery System by FDM 3D Printing. Pharmaceutics 13:10, pages 1714.
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Fojan Rafiei, Hadi Tabesh, Shayan Farzad, Farah Farzaneh, Maryam Rezaei, Fateme Hosseinzade & Khosrow Mottaghy. (2021) Development of Hormonal Intravaginal Rings: Technology and Challenges. Geburtshilfe und Frauenheilkunde 81:07, pages 789-806.
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Ghorbanali Sharifzadeh, Hadi Hezaveh, Ida Idayu Muhamad, Shahrir Hashim & Nozieana Khairuddin. (2020) Montmorillonite-based polyacrylamide hydrogel rings for controlled vaginal drug delivery. Materials Science and Engineering: C 110, pages 110609.
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Peter Boyd, Bruce Variano, Patrick Spence, Clare F. McCoy, Diarmaid J. Murphy, Yahya H. Dallal Bashi & R. Karl Malcolm. (2019) In vitro release testing methods for drug-releasing vaginal rings. Journal of Controlled Release 313, pages 54-69.
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Diarmaid J. Murphy, Clare F. McCoy, Marlena Plagianos, Saumya RamaRao, Ruth Merkatz, Heather Clark, Peter Boyd, Bruce Variano & R. Karl Malcolm. (2019) Post-use ring weight and residual drug content as potential objective measures of user adherence to a contraceptive progesterone vaginal ring. Contraception 100:3, pages 241-246.
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I. Koutsamanis, S. Eder, M. Beretta, A. Witschnigg, A. Paudel, K. Nickisch, M. Friedrich, K. Eggenreich & E. Roblegg. (2019) Formulation and processability screening for the rational design of ethylene-vinyl acetate based intra-vaginal rings. International Journal of Pharmaceutics 564, pages 90-97.
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Clare F. McCoy, Bronagh G. Millar, Diarmaid J. Murphy, Wendy Blanda, Bashir Hansraj, Brid Devlin, R. Karl Malcolm & Peter Boyd. (2019) Mechanical testing methods for drug-releasing vaginal rings. International Journal of Pharmaceutics 559, pages 182-191.
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María-Dolores Veiga-Ochoa, Roberto Ruiz-Caro, Raúl Cazorla-Luna, Araceli Martín-Illana & Fernando Notario-Pérez. 2018. Advances in HIV and AIDS Control. Advances in HIV and AIDS Control.
Diarmaid J. Murphy, Delphine Desjardins, Peter Boyd, Nathalie Dereuddre-Bosquet, Lev Stimmer, Anna Caldwell, Roger Le Grand, Charles Kelly, Jens van Roey & R. Karl Malcolm. (2018) Impact of ring size and drug loading on the pharmacokinetics of a combination dapivirine-darunavir vaginal ring in cynomolgus macaques. International Journal of Pharmaceutics 550:1-2, pages 300-308.
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Yujing Wang, Peter Boyd, Alyson Hunter & R. Karl Malcolm. (2018) Intravaginal rings for continuous low-dose administration of cervical ripening agents. International Journal of Pharmaceutics 549:1-2, pages 124-132.
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Clare F. McCoy, David C. Apperley, Bruce Variano, Heather Sussman, Daniel Loeven, Peter Boyd & R. Karl Malcolm. (2018) Solid state 13C NMR spectroscopy provides direct evidence for reaction between ethinyl estradiol and a silicone elastomer vaginal ring drug delivery system. International Journal of Pharmaceutics 548:1, pages 689-697.
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Webster Mavhu, Elizabeth Rowley, Ibou Thior, Natalie Kruse-Levy, Owen Mugurungi, Getrude Ncube & Suzanne Leclerc-Madlala. (2018) Sexual behavior experiences and characteristics of male-female partnerships among HIV positive adolescent girls and young women: Qualitative findings from Zimbabwe. PLOS ONE 13:3, pages e0194732.
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Michael T. Cook & Marc B. Brown. (2018) Polymeric gels for intravaginal drug delivery. Journal of Controlled Release 270, pages 145-157.
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Ian Major & Christopher McConville. (2017) Vaginal drug delivery for the localised treatment of cervical cancer. Drug Delivery and Translational Research 7:6, pages 817-828.
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Hongbin Zhang, John K. Jackson & Mu Chiao. (2017) Microfabricated Drug Delivery Devices: Design, Fabrication, and Applications. Advanced Functional Materials 27:45, pages 1703606.
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Clare F. McCoy, Diarmaid J. Murphy, Peter Boyd, Tiffany Derrick, Patrick Spence, Brid Devlin & R. Karl Malcolm. (2017) Packing Polymorphism of Dapivirine and Its Impact on the Performance of a Dapivirine-Releasing Silicone Elastomer Vaginal Ring. Journal of Pharmaceutical Sciences 106:8, pages 2015-2025.
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Liselotte Hardy, Vicky Jespers, Irith De Baetselier, Jozefien Buyze, Lambert Mwambarangwe, Viateur Musengamana, Janneke van de Wijgert & Tania Crucitti. (2017) Association of vaginal dysbiosis and biofilm with contraceptive vaginal ring biomass in African women. PLOS ONE 12:6, pages e0178324.
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Magdalena Prokopowicz, Adrian Szewczyk, Rafał Łunio & Wiesław Sawicki. (2017) Monolithic polydimethylsiloxane-modified silica composites prepared by a low-temperature sol–gel micromolding technique for controlled drug release. Reactive and Functional Polymers 114, pages 136-145.
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Amesika N Nyaku, Sean G Kelly & Babafemi O Taiwo. (2017) Long-Acting Antiretrovirals: Where Are We now?. Current HIV/AIDS Reports 14:2, pages 63-71.
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Stella E. Aniagyei, Lee B. Sims, Danial A. Malik, Kevin M. Tyo, Keegan C. Curry, Woihwan Kim, Daniel A. Hodge, Jinghua Duan & Jill M. Steinbach-Rankins. (2017) Evaluation of poly(lactic-co-glycolic acid) and poly( dl -lactide-co-ε-caprolactone) electrospun fibers for the treatment of HSV-2 infection. Materials Science and Engineering: C 72, pages 238-251.
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Paul F. McKay, Jamie F.S. Mann, Aditya Pattani, Vicky Kett, Yoann Aldon, Deborah King, R. Karl Malcolm & Robin J. Shattock. (2017) Intravaginal immunisation using a novel antigen-releasing ring device elicits robust vaccine antigen-specific systemic and mucosal humoral immune responses. Journal of Controlled Release 249, pages 74-83.
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Anna Externbrink, Karin Eggenreich, Simone Eder, Stefan Mohr, Klaus Nickisch & Sandra Klein. (2017) Development and evaluation of accelerated drug release testing methods for a matrix-type intravaginal ring. European Journal of Pharmaceutics and Biopharmaceutics 110, pages 1-12.
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Ariane van der Straten, Lori Panther, Nicole Laborde, Craig J. Hoesley, Helen Cheng, Marla J. Husnik, Stephanie Horn, Annalene Nel, Lydia Soto-Torres & Beatrice A. Chen. (2016) Adherence and Acceptability of a Multidrug Vaginal Ring for HIV Prevention in a Phase I Study in the United States. AIDS and Behavior 20:11, pages 2644-2653.
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David R. Friend. (2016) Development of controlled release systems over the past 50 years in the area of contraception. Journal of Controlled Release 240, pages 235-241.
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Peter Boyd, Susan M. Fetherston, Clare F. McCoy, Ian Major, Diarmaid J. Murphy, Sandeep Kumar, Jonathon Holt, Andrew Brimer, Wendy Blanda, Brid Devlin & R. Karl Malcolm. (2016) Matrix and reservoir-type multipurpose vaginal rings for controlled release of dapivirine and levonorgestrel. International Journal of Pharmaceutics 511:1, pages 619-629.
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R. Karl Malcolm, Peter J. Boyd, Clare F. McCoy & Diarmaid J. Murphy. (2016) Microbicide vaginal rings: Technological challenges and clinical development. Advanced Drug Delivery Reviews 103, pages 33-56.
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José das Neves, João Pedro Martins & Bruno Sarmento. (2016) Will dapivirine redeem the promises of anti-HIV microbicides? Overview of product design and clinical testing. Advanced Drug Delivery Reviews 103, pages 20-32.
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Sasha Rios, Matthew A. Petersen & James H. Arps. (2016) Tandem Delivery Platform for Small Molecules and Biologic Pharmaceuticals Via Silicone Foam1. Journal of Medical Devices 10:2.
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Patrick Spence, Annalene Nel, Neliëtte van Niekerk, Tiffany Derrick, Susan Wilder & Bríd Devlin. (2016) Post-use assay of vaginal rings (VRs) as a potential measure of clinical trial adherence. Journal of Pharmaceutical and Biomedical Analysis 125, pages 94-100.
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Diarmaid J. Murphy, Katie Amssoms, Geert Pille, Aileen Clarke, Marc O’Hara, Jens van Roey & R. Karl Malcolm. (2016) Sustained release of the candidate antiretroviral peptides T-1249 and JNJ54310516-AFP from a rod insert vaginal ring. Drug Delivery and Translational Research 6:3, pages 234-242.
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Diarmaid J. Murphy, Peter Boyd, Clare F. McCoy, Sandeep Kumar, Jonathon D.S. Holt, Wendy Blanda, Andrew N. Brimer & R. Karl Malcolm. (2016) Controlling levonorgestrel binding and release in a multi-purpose prevention technology vaginal ring device. Journal of Controlled Release 226, pages 138-147.
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Céline Schurmans, Irith De Baetselier, Evelyne Kestelyn, Vicky Jespers, Thérèse Delvaux, Stephen K Agaba, Harry van Loen, Joris Menten, Janneke van de Wijgert & Tania Crucitti. (2015) The ring plus project: safety and acceptability of vaginal rings that protect women from unintended pregnancy. BMC Public Health 15:1.
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Kavita Nanda, Rebecca Callahan & Laneta Dorflinger. (2015) Addressing Gaps in the Contraceptive Method Mix: Methods in Development. Women's Health 11:6, pages 729-735.
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Sophia G. Antimisiaris & Spyridon Mourtas. (2015) Recent advances on anti-HIV vaginal delivery systems development. Advanced Drug Delivery Reviews 92, pages 123-145.
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Cynthia Woodsong & Jonathon D.S. Holt. (2015) Acceptability and preferences for vaginal dosage forms intended for prevention of HIV or HIV and pregnancy. Advanced Drug Delivery Reviews 92, pages 146-154.
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Daniel Sepúlveda-Crespo, Rafael Gómez, Francisco Javier De La Mata, José Luis Jiménez & Mª. Ángeles Muñoz-Fernández. (2015) Polyanionic carbosilane dendrimer-conjugated antiviral drugs as efficient microbicides: Recent trends and developments in HIV treatment/therapy. Nanomedicine: Nanotechnology, Biology and Medicine 11:6, pages 1481-1498.
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Patrick Spence, Anita Bhatia Garg, Cynthia Woodsong, Brid Devin & Zeda Rosenberg. (2015) Recent work on vaginal rings containing antiviral agents for HIV prevention. Current Opinion in HIV and AIDS 10:4, pages 264-270.
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Peter Boyd, Delphine Desjardins, Sandeep Kumar, Susan M. Fetherston, Roger Le-Grand, Nathalie Dereuddre-Bosquet, Berglind Helgadóttir, Ásgeir Bjarnason, Manjula Narasimhan & R. Karl Malcolm. (2015) A Temperature-Monitoring Vaginal Ring for Measuring Adherence. PLOS ONE 10:5, pages e0125682.
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José das Neves & Bruno Sarmento. (2015) Precise engineering of dapivirine-loaded nanoparticles for the development of anti-HIV vaginal microbicides. Acta Biomaterialia 18, pages 77-87.
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Gita Ramjee & Sarita Naidoo. (2015) The road ahead: working towards effective clinical translation of biomedical HIV prevention strategies. Future Virology 10:3, pages 271-282.
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Cynthia Woodsong, Jonathon Holt, Brid Devlin & Zeda Rosenberg. (2015) Current Status of Multipurpose Prevention Technology (MPT) Development. Current Obstetrics and Gynecology Reports 4:1, pages 43-52.
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Christopher McConville, James M. Smith, Clare F. McCoy, Priya Srinivasan, James Mitchell, Angela Holder, Ron A. Otten, Salvatore Butera, Gustavo F. Doncel, David R. Friend & R. Karl Malcolm. (2015) Lack of in vitro–in vivo correlation for a UC781-releasing vaginal ring in macaques. Drug Delivery and Translational Research 5:1, pages 27-37.
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Jill M. Steinbach. (2014) Protein and oligonucleotide delivery systems for vaginal microbicides against viral STIs. Cellular and Molecular Life Sciences 72:3, pages 469-503.
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Udita Das, Mamta Sharma, Maggie Kilbourne-Brook & Patricia S. Coffey. (2015) Exploring vaginal ring acceptability for contraception and sexually transmissible infection protection in India: a qualitative research study. Sexual Health 12:6, pages 532.
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Manjula Gunawardana, Marc M. Baum, Thomas J. Smith & John A. Moss. (2014) An Intravaginal Ring for the Sustained Delivery of Antibodies. Journal of Pharmaceutical Sciences 103:11, pages 3611-3620.
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