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ImmunoTargets and Therapy Volume 8, 2019 - Issue
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Original Research

Gasdermin D Hypermethylation Inhibits Pyroptosis And LPS-Induced IL-1β Release From NK92 Cells

Jibran Sualeh MuhammadCollege of Medicine, and the Immuno-Oncology Group, Sharjah Institute for Medical Research, University of Sharjah, Sharjah27272, United Arab EmiratesORCID Iconhttps://orcid.org/0000-0002-9565-1062View further author information
ORCID Icon,
Manju Nidagodu JayakumarCollege of Medicine, and the Immuno-Oncology Group, Sharjah Institute for Medical Research, University of Sharjah, Sharjah27272, United Arab EmiratesView further author information
,
Noha Mousaad ElemamCollege of Medicine, and the Immuno-Oncology Group, Sharjah Institute for Medical Research, University of Sharjah, Sharjah27272, United Arab EmiratesORCID Iconhttps://orcid.org/0000-0002-3586-6731View further author information
ORCID Icon,
Thenmozhi VenkatachalamCollege of Medicine, and the Immuno-Oncology Group, Sharjah Institute for Medical Research, University of Sharjah, Sharjah27272, United Arab EmiratesView further author information
,
Tom Kalathil RajuCollege of Medicine, and the Immuno-Oncology Group, Sharjah Institute for Medical Research, University of Sharjah, Sharjah27272, United Arab EmiratesView further author information
,
Rifat Akram HamoudiCollege of Medicine, and the Immuno-Oncology Group, Sharjah Institute for Medical Research, University of Sharjah, Sharjah27272, United Arab EmiratesORCID Iconhttps://orcid.org/0000-0002-1402-0868View further author information
ORCID Icon &
Azzam A MaghazachiCollege of Medicine, and the Immuno-Oncology Group, Sharjah Institute for Medical Research, University of Sharjah, Sharjah27272, United Arab EmiratesCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-3310-678XView further author information
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Pages 29-41 | Published online: 14 Oct 2019

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Asma Almansoori, Poorna Manasa Bhamidimarri, Riyad Bendardaf & Rifat Hamoudi. (2022) In silico Analysis of Publicly Available Transcriptomics Data Identifies Putative Prognostic and Therapeutic Molecular Targets for Papillary Thyroid Carcinoma. International Journal of General Medicine 15, pages 3097-3120.
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Mena Al-Ani, Noha Mousaad Elemam, Jennifer Elisabeth Hundt & Azzam A Maghazachi. (2020) Drugs for Multiple Sclerosis Activate Natural Killer Cells: Do They Protect Against COVID-19 Infection?. Infection and Drug Resistance 13, pages 3243-3254.
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Articles from other publishers (19)

Giuseppe Privitera, Nitish Rana, Alessandro Armuzzi & Theresa T. Pizarro. (2023) The gasdermin protein family: emerging roles in gastrointestinal health and disease. Nature Reviews Gastroenterology & Hepatology 20:6, pages 366-387.
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Xiaolu Zhang, Ziyu Wang, Yujia Zheng, Qun Yu, Miao Zeng, Liding Bai, Lin Yang, Maojuan Guo, Xijuan Jiang & Jiali Gan. (2023) Inhibitors of the NLRP3 inflammasome pathway as promising therapeutic candidates for inflammatory diseases (Review). International Journal of Molecular Medicine 51:4.
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Asmaa El-Kenawi, Anders Berglund, Veronica Estrella, Yonghong Zhang, Min Liu, Ryan M. Putney, Sean J. Yoder, Joseph Johnson, Joel Brown & Robert Gatenby. (2023) Elevated Methionine Flux Drives Pyroptosis Evasion in Persister Cancer Cells. Cancer Research 83:5, pages 720-734.
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Antonio Beato, Laura Della Torre, Vincenza Capone, Daniela Carannante, Gregorio Favale, Giulia Verrilli, Lucia Altucci & Vincenzo Carafa. 2023. Cell Death and Disease. Cell Death and Disease.
FakhiraSaif Alketbi, AmirAli Khan, MuhammadTehsil Gul, MuhammadNasir Khan Khattak, ManjuNidagodu Jayakumar & AR Samsudin. (2023) The effects of epigenetic modifiers on the differentiation of human dental pulp stem cells into neural progenitor-like cells. Advances in Biomedical and Health Sciences 0:0, pages 0.
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Jinqiang Zhang, Dapeng Su, Qin Liu, Qingsong Yuan, Zhen Ouyang, Yuan Wei, Chenghong Xiao, Liangyuan Li, Changgui Yang, Weike Jiang, Lanping Guo & Tao Zhou. (2022) Gasdermin D-mediated microglial pyroptosis exacerbates neurotoxicity of aflatoxins B1 and M1 in mouse primary microglia and neuronal cultures. NeuroToxicology 91, pages 305-320.
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Irena Majkutewicz. (2022) Dimethyl fumarate: A review of preclinical efficacy in models of neurodegenerative diseases. European Journal of Pharmacology 926, pages 175025.
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Zihao Li, Senlin Ji, Mei-Ling Jiang, Yun Xu & Cun-Jin Zhang. (2022) The Regulation and Modification of GSDMD Signaling in Diseases. Frontiers in Immunology 13.
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Colleen Elsa Johns & Lakshmi Galam. (2022) Guanylate Binding Protein 1 (GBP1): A Key Protein in Inflammatory Pyroptosis. Cell Biochemistry and Biophysics 80:2, pages 295-299.
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Yusheng Shen, Hao Chi, Ke Xu, Yandong Li, Xisheng Yin, Shi Chen, Qian Yang, Miao He, Guohua Zhu & Xiaosong Li. (2022) A Novel Classification Model for Lower-Grade Glioma Patients Based on Pyroptosis-Related Genes. Brain Sciences 12:6, pages 700.
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Emilie Bourdonnay & Thomas Henry. (2022) Transcriptional and Epigenetic Regulation of Gasdermins. Journal of Molecular Biology 434:4, pages 167253.
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David Sarrió, Jeannette Martínez-Val, Ángela Molina-Crespo, Laura Sánchez & Gema Moreno-Bueno. (2021) The multifaceted roles of gasdermins in cancer biology and oncologic therapies. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1876:2, pages 188635.
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Noha Mousaad Elemam, Rakhee K. Ramakrishnan, Jennifer E. Hundt, Rabih Halwani, Azzam A. Maghazachi & Qutayba Hamid. (2021) Innate Lymphoid Cells and Natural Killer Cells in Bacterial Infections: Function, Dysregulation, and Therapeutic Targets. Frontiers in Cellular and Infection Microbiology 11.
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Raafat El-Awady, Ekram Saleh, Rifat Hamoudi, Wafaa S. Ramadan, Ralph Mazitschek, Manal A. Nael, Khaled M. Elokely, Magid Abou-Gharbia, Wayne E. Childers, Vunnam Srinivasulu, Lujain Aloum, Varsha Menon & Taleb H. Al-Tel. (2021) Discovery of novel class of histone deacetylase inhibitors as potential anticancer agents. Bioorganic & Medicinal Chemistry 42, pages 116251.
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Yixin Tan, Quanzhu Chen, Xiaoling Li, Zhaoyang Zeng, Wei Xiong, Guiyuan Li, Xiayu Li, Jianbo Yang, Bo Xiang & Mei Yi. (2021) Pyroptosis: a new paradigm of cell death for fighting against cancer. Journal of Experimental & Clinical Cancer Research 40:1.
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Honggang Xiong, Xianbin Ma, Xiaolong Wang, Wen Su, Lei Wu, Tian Zhang, Zhigang Xu & Zhi‐Jun Sun. (2021) Inspired Epigenetic Modulation Synergy with Adenosine Inhibition Elicits Pyroptosis and Potentiates Cancer Immunotherapy. Advanced Functional Materials 31:20, pages 2100007.
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Sarah Dhaiban, Mena Al-Ani, Noha Mousaad Elemam, Mahmood H. Al-Aawad, Zeinab Al-Rawi & Azzam A. Maghazachi. (2021) Role of Peripheral Immune Cells in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis. Sci 3:1, pages 12.
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Fiachra Humphries, Liraz Shmuel-GaliaNatalia Ketelut-Carneiro, Sheng LiBingwei Wang, Venkatesh V. Nemmara, Ruth WilsonZhaozhao JiangFarnaz KhalighinejadKhaja MuneeruddinScott A. Shaffer, Ranjan Dutta, Carolina IoneteScott PesiridisShuo Yang, Paul R. Thompson & Katherine A. Fitzgerald. (2020) Succination inactivates gasdermin D and blocks pyroptosis. Science 369:6511, pages 1633-1637.
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Mahmood Y Hachim, Bariaa A Khalil, Noha M Elemam & Azzam A Maghazachi. (2020) Pyroptosis: The missing puzzle among innate and adaptive immunity crosstalk. Journal of Leukocyte Biology 108:1, pages 323-338.
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